DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phae1 and TMPRSS11E

DIOPT Version :9

Sequence 1:	NP_001285870.1	Gene:	Phae1 / 34637	FlyBaseID:	FBgn0263234	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_054777.2	Gene:	TMPRSS11E / 28983	HGNCID:	24465	Length:	423	Species:	Homo sapiens

Alignment Length:	238	Identity:	70/238 - (29%)
Similarity:	111/238 - (46%)	Gaps:	16/238 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RVVGGSPAAVNSAPYAVSMQYGGTHYCAASILNANWLVTAAHCLTNSNQVLGSTLVAGSIAVDGT 99
            |:|||:.......|:..|:|:.|:|.|.|:::||.|||:||||.|........|...| :.:
Human   191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNPARWTASFG-VTI--- 251

  Fly   100 ASTTQTRSITYFVINDLYTGGTVPYDIGMIYTPTAFVWSAAVAPVTLPSSG--VVPTGTANLYGW 162
            ..:...|.:...::::.|...:..|||.:....:...::.||..|.||.:.  ..|.....:.|:
Human   252 KPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGF 316

  Fly   163 GSTSTTNTASYPSTLQVATNVPIISLSSCESALGTKGSDVHSTNLCTGPLTGGVSICTSDSGGPL 227
            |:..  |.....:.|:.| .|.:|..::|........: :....||.|.|.|....|..||||||
Human   317 GALK--NDGYSQNHLRQA-QVTLIDATTCNEPQAYNDA-ITPRMLCAGSLEGKTDACQGDSGGPL 377

  Fly   228 VQGNV-----LIGIVSWGKLPCGQANSPSVYVQVSSFISWISA 265
            |..:.     |.||||||. .|.:.|.|.||.:|::...||::
Human   378 VSSDARDIWYLAGIVSWGD-ECAKPNKPGVYTRVTALRDWITS 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phae1	NP_001285870.1	Tryp_SPc	35..263	CDD:214473	68/234 (29%)
Phae1	NP_001285870.1	Tryp_SPc	36..266	CDD:238113	69/237 (29%)
TMPRSS11E	NP_054777.2	SEA	51..156	CDD:307516
TMPRSS11E	NP_054777.2	Tryp_SPc	192..420	CDD:238113	69/237 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920