DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phae1 and tmprss6

DIOPT Version :9

Sequence 1:	NP_001285870.1	Gene:	Phae1 / 34637	FlyBaseID:	FBgn0263234	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	257	Identity:	71/257 - (27%)
Similarity:	109/257 - (42%)	Gaps:	28/257 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 CRISGVAIGAPEGRVVGGSPAAVNSAPYAVSMQYGGTHYCAASILNANWLVTAAHCLTNSNQVLG 86
            |.|..|.|     |:|||:.|.....|:..|:|..|.|.|..:::...|::|||||.|..:....
Frog   562 CGIQAVGI-----RLVGGTQAQEGEWPWQASLQVRGEHICGGTLVADQWILTAAHCFTPESYASP 621

  Fly    87 S--TLVAGSIAVDGTASTTQTRSITYFVINDLYTGGTVPYDIGMI----YTPTAFVWSAAVAPVT 145
            .  |:..|.:.:..:........:...||:..|...:..||:.::    ..|   :.|..|.|:.
Frog   622 EVWTVYLGKVRLSRSTQKELAFKVIRLVIHPFYDEDSHDYDVALVLLDHLVP---LTSPHVQPIC 683

  Fly   146 LPSS-GVVPTGTAN-LYGWGSTSTTNTASYPSTLQVATNVPIISLSSCESALGTKGSDVHSTNLC 208
            |||| ...|||::. :.||||.......|  ..|| ..::.:::...|......:   :....||
Frog   684 LPSSTHHFPTGSSCWVTGWGSVKENGPTS--DVLQ-KVDIQLVAQDICTELYRYQ---ISPRMLC 742

  Fly   209 TGPLTGGVSICTSDSGGPLV----QGN-VLIGIVSWGKLPCGQANSPSVYVQVSSFISWISA 265
            .|...|....|..|||.|||    .|. ...|:|||| ..||......||.:::..:.||.:
Frog   743 AGYRDGSKDACQGDSGSPLVCKTASGRWFQAGLVSWG-AGCGIPRYFGVYSRITRLVQWIES 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phae1	NP_001285870.1	Tryp_SPc	35..263	CDD:214473	65/240 (27%)
Phae1	NP_001285870.1	Tryp_SPc	36..266	CDD:238113	66/243 (27%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060
		LDLa	525..560	CDD:238060
		Tryp_SPc	572..804	CDD:238113	66/242 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920