DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rab6 and RAB6C

DIOPT Version :9

Sequence 1:	NP_001285869.1	Gene:	Rab6 / 34636	FlyBaseID:	FBgn0015797	Length:	208	Species:	Drosophila melanogaster
Sequence 2:	NP_115520.2	Gene:	RAB6C / 84084	HGNCID:	16525	Length:	254	Species:	Homo sapiens

Alignment Length:	207	Identity:	165/207 - (79%)
Similarity:	178/207 - (85%)	Gaps:	1/207 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLW 66
            :.||||||||||||||||||||.||||||||.||||||||||.||||||||||||||.|:.|:||
Human     3 AGGDFGNPLRKFKLVFLGEQSVAKTSLITRFRYDSFDNTYQAIIGIDFLSKTMYLEDGTIGLRLW 67

  Fly    67 DTAGQERFRSLIPSYIRDSTVAVVVYDITNTNSFHQTSKWIDDVRTERGSDVIIMLVGNKTDLSD 131
            |||||||.|||||.|||||..|||||||||.|||.||:||||||||||||||||.||||:|||:|
Human    68 DTAGQERLRSLIPRYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIITLVGNRTDLAD 132

  Fly   132 KRQVSTEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMDSTENKPSEDMQEVVLKDSP 196
            |||||.||||||||.|||.||||.|||||||||||||||||||||:||::...|||.::.| :.|
Human   133 KRQVSVEEGERKAKGLNVTFIETRAKAGYNVKQLFRRVAAALPGMESTQDGSREDMSDIKL-EKP 196

  Fly   197 NETKDPEGGCAC 208
            .|....||||:|
Human   197 QEQTVSEGGCSC 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab6	NP_001285869.1	Rab6	13..173	CDD:206654	138/159 (87%)
RAB6C	NP_115520.2	Required for centrosome localization	1..174		147/170 (86%)
		Rab6	14..174	CDD:206654	138/159 (87%)
		RAB	14..171	CDD:197555	135/156 (87%)
		Effector region. /evidence=ECO:0000250	42..50		6/7 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0094
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2215
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1277051at2759
OrthoFinder	1	1.000	-	-		FOG0000767
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24073
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X452
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.930