DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab6 and RAB6B

DIOPT Version :9

Sequence 1:	NP_001285869.1	Gene:	Rab6 / 34636	FlyBaseID:	FBgn0015797	Length:	208	Species:	Drosophila melanogaster
Sequence 2:	NP_057661.3	Gene:	RAB6B / 51560	HGNCID:	14902	Length:	208	Species:	Homo sapiens

Alignment Length:	207	Identity:	174/207 - (84%)
Similarity:	188/207 - (90%)	Gaps:	1/207 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLW 66
            :.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human     3 AGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLW 67

  Fly    67 DTAGQERFRSLIPSYIRDSTVAVVVYDITNTNSFHQTSKWIDDVRTERGSDVIIMLVGNKTDLSD 131
            ||||||||||||||||||||||||||||||.|||.||||||||||||||||||||||||||||:|
Human    68 DTAGQERFRSLIPSYIRDSTVAVVVYDITNLNSFQQTSKWIDDVRTERGSDVIIMLVGNKTDLAD 132

  Fly   132 KRQVSTEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMDSTENKPSEDMQEVVLKDSP 196
            |||::.||||::||||:|||||||||.||||||||||||:|||||::.:.|..|.|.::.| |.|
Human   133 KRQITIEEGEQRAKELSVMFIETSAKTGYNVKQLFRRVASALPGMENVQEKSKEGMIDIKL-DKP 196

  Fly   197 NETKDPEGGCAC 208
            .|....||||:|
Human   197 QEPPASEGGCSC 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab6	NP_001285869.1	Rab6	13..173	CDD:206654	148/159 (93%)
RAB6B	NP_057661.3	Rab6	14..174	CDD:206654	148/159 (93%)
RAB6B	NP_057661.3	Effector region. /evidence=ECO:0000250	42..50		7/7 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0094
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2215
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1277051at2759
OrthoFinder	1	1.000	-	-		FOG0000767
OrthoInspector	1	1.000	-	-		otm42107
orthoMCL	1	0.900	-	-		OOG6_100976
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X452
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.730