DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patsas and AKR2

DIOPT Version :9

Sequence 1:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_014677.1	Gene:	AKR2 / 854199	SGDID:	S000005560	Length:	749	Species:	Saccharomyces cerevisiae

Alignment Length:	636	Identity:	141/636 - (22%)
Similarity:	242/636 - (38%)	Gaps:	159/636 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 HGSSGVEDHENVLLFEGLDGATTVSLDDIF-DIIKNGEVSEVENLVDKFGMECLSAR-DRHGYTP 152
            |..|..::::..||.   ||:.|..:.||| :..|:|::..|:::|:...::..:.| |.  .:.
Yeast    28 HAVSDSDNNKAQLLG---DGSNTEYVVDIFIEAAKDGDLKVVKDVVESGAVDINNDRIDE--LSG 87

  Fly   153 AHWIALNGNVQLMRYLIERTAPIDLPCLGTQGPRPIHWACRKGHASVVQVLLQAGVAVNAADFKG 217
            .||..:|....:.::|:.|.|..: ...|..|...:|||.|.|:..:|.:||:.|......|.:|
Yeast    88 LHWACINNRFSVAKFLLLRGANPN-QAAGPGGATALHWAARYGNIYIVDLLLKHGADPTLKDEQG 151

  Fly   218 LTPLHLACMYGRTATAAYLLGMGALNN------LTDINGDTALHWAAYKGHADLMRLLMYSGVEL 276
            |..:|.:..........|:|.....||      ..|.|..|.|.||||:|....:.||:..|..:
Yeast   152 LNIMHFSVYSSNILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWAAYQGDFLTVELLLKFGSTV 216

  Fly   277 QKTDNFGSTPLHLACLSGNMTCVRLLCEKSQLDLEPRDKNGK------------TPIMLAQAHQH 329
            ..|||.|...||.|.:.|:.   |::|:.........::|.:            |..:..||.||
Yeast   217 AWTDNRGFNALHCALVGGDQ---RVICDLILSGANFYERNNQKQDCFDLAEGMGTKSLFEQALQH 278

  Fly   330 QDVVRLLYGEVKKKSRWIPSVSESWGWLFGGAGDSKGPLFLFLFSVLLWGY-------P----MY 383
            ....||  |..|.|             ||..:..::..:||..|.::::.|       |    |.
Yeast   279 HGYDRL--GNQKDK-------------LFKKSSHAQFTIFLSPFLLMVYIYLISLVLSPVLAIML 328

  Fly   384 MIRAIPITWNILRR---------------------------SHYCF-IY-WNAVMW--------- 410
            .:....:..|.|::                           |.:|| || |...::
Yeast   329 SLLVTVVMVNTLKKFVLPCLPRKNTYKVSLTRTPFFSGLFLSTFCFLIYIWTKKLYPYSVSDYTM 393

  Fly   411 --ISWAIAN-----------RRDPGYIPL--SSDAYYRAIKQIPYFDKLKKRNVMLTRLCHSCRC 460
              :.:.:.:           |.|||.:..  |..:....|||:....|..:.|     .|.....
Yeast   394 KNVQFLVTSFLTVVLFLRLVRSDPGCLKTDDSLTSIQETIKQLIDLGKFDREN-----FCVETLE 453

  Fly   461 LRPLRAKHCRVCNRCVSYFDHHCPFIYNCVGLRNRMWFFLFVLSVAVNCSFTIYFACY------- 518
            .:|||:|:.......|:.:||:||:|||.|||:|...|..|.::|..: .|...:.|.
Yeast   454 RKPLRSKYSFFSGALVARYDHYCPWIYNDVGLKNHKLFVFFAVTVQYH-MFLFMWLCLAYFKKTN 517

  Fly   519 -----------CVMIEGFTM---------LYVLGLIEAVVFCGLGWILTCTSILHACMNLTTNEM 563
                       |.:::..|:         .:.|.:..:|.|..||.:| ..........:||.|:
Yeast   518 YIYEQVEEYARCALLKNETLCKGSNYDPSTFFLFIWISVNFIWLGAML-IVQFFQILKGITTPEL 581

  Fly   564 FNYKRYPYLRDKRGRYQNPFSRGPILNLLEF---FVCLPDRG-DDNDLLLE 610
            |...:..:             :...:||:.|   ......:| :|:|::.|
Yeast   582 FILIKEEH-------------KAKFINLIPFENSIYTSESKGVEDSDMIPE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738	56/200 (28%)
		ANK repeat	148..181	CDD:293786	6/32 (19%)
		ANK repeat	187..214	CDD:293786	9/26 (35%)
		ANK repeat	216..247	CDD:293786	7/36 (19%)
		ANK repeat	249..280	CDD:293786	11/30 (37%)
		ANK repeat	282..314	CDD:293786	7/31 (23%)
		Ank_4	283..336	CDD:316185	14/64 (22%)
		DHHC	455..567	CDD:334580	34/138 (25%)
AKR2	NP_014677.1	ANKYR	1..195	CDD:223738	44/172 (26%)
		ANK repeat	54..81	CDD:293786	5/26 (19%)
		ANK repeat	83..115	CDD:293786	7/34 (21%)
		ANK repeat	117..148	CDD:293786	10/30 (33%)
		ANK repeat	189..220	CDD:293786	11/30 (37%)
		Ank_4	190..243	CDD:372654	20/55 (36%)
		ANK repeat	222..247	CDD:293786	7/27 (26%)
		COG5273	340..711	CDD:227598	58/300 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I2290
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54696
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101007
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R35
SonicParanoid	1	1.000	-	-		X628
TreeFam	0	0.000	Not matched by this tool.
	7	6.750