DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patsas and AKR1

DIOPT Version :9

Sequence 1:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_010550.1	Gene:	AKR1 / 851857	SGDID:	S000002672	Length:	764	Species:	Saccharomyces cerevisiae

Alignment Length:	660	Identity:	154/660 - (23%)
Similarity:	241/660 - (36%)	Gaps:	175/660 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 EEDGHAHADDIHLDHRPHSPPLTGRGTDGGHGSSGVEDHENVLLFEGLDGATTVSLDDIFDIIKN 124
            ||.|:...:  |.|.....|.||...|....|                |.||      :.::| :
Yeast    55 EESGNEQVN--HNDEAEEDPLLTRYHTACQRG----------------DLAT------VKEMI-H 94

  Fly   125 GEVSEVENLVDKFGMECLSARDRHGYTPAHWIALNGNVQLMRYLIERTAPIDLPCLGTQGPRPIH 189
            |::.||.|..|.         ..| .|..||.::|..:.::.:|:.:.|.::... |.....|:|
Yeast    95 GKLLEVNNDGDS---------TEH-ITGLHWASINNRLSVVDFLVSQGADVNARA-GALHATPLH 148

  Fly   190 WACRKGHASVVQVLLQAGVAVNAADFKGLTPLHLACMYGRTATAAYLLGMGALNNLTDIN----- 249
            ||.|.|:..:|..||:.|......|.:|...|||:..........|:|.......|.||:
Yeast   149 WAARYGYVYIVDFLLKHGADPTMTDDQGFNLLHLSVNSSNIMLVLYVLFNVVSKGLLDIDCRDPK 213

  Fly   250 GDTALHWAAYKGHADLMRLLMYSGVELQKTDNFGSTPLHLACLSGNMTCVRLLCEKSQLDLEPRD 314
            |.|:|.||||:|.:..:..|:..|..::..|..|.||||...:.|....::.|.:.. .|...:.
Yeast   214 GRTSLLWAAYQGDSLTVAELLKFGASIKIADTEGFTPLHWGTVKGQPHVLKYLIQDG-ADFFQKT 277

  Fly   315 KNGKTPIMLAQ------------AHQHQDVVRLLYGEVKKKSRWIPSVSESWGWLFGGAG----D 363
            ..||....:||            .|...|.......:..|||:....|:....:||.|..    .
Yeast   278 DTGKDCFAIAQEMNTVYSLREALTHSGFDYHGYPIKKWFKKSQHAKLVTFITPFLFLGIAFALFS 342

  Fly   364 SKGPLF----LFL-------------------------------------FSVLLWGYPMYMIRA 387
            ...|||    |||                                     |..|||...::..:.
Yeast   343 HINPLFVIIVLFLLAIATNKGLNKFVLPSYGRMGVHNVTLLRSPLLSGVFFGTLLWVTIVWFFKV 407

  Fly   388 IPITW------NILRRSHYCFIYWNAVMWISWAIANRRDPGYIPLSSD--AYYRAIKQIPYFDKL 444
            :|.|:      |||     ..:...:|.::...:. ..|||.:|..:|  ...:.|..:....|.
Yeast   408 MPRTFSDEQYTNIL-----MLVILVSVFYLFGQLV-IMDPGCLPEETDHENVRQTISNLLEIGKF 466

  Fly   445 KKRNVMLTRLCHSCRCLRPLRAKHCRVCNRCVSYFDHHCPFIYNCVGLRNRMWFFLFVLSVAVNC 509
            ..:|     .|......:|||:|...:.|..|:.|||:||:|:|.|||:|.. .|:|.:::..:.
Yeast   467 DTKN-----FCIETWIRKPLRSKFSPLNNAVVARFDHYCPWIFNDVGLKNHK-AFIFFITLMESG 525

  Fly   510 SFTIYFACYCVMIEGFTML--------------YVLG--------LIEAVVFCGLGWILT----C 548
            .||....|    :|.|..|              ::||        :.:..||..|.|.|.    .
Yeast   526 IFTFLALC----LEYFDELEDAHEDTSQKNGKCFILGASDLCSGLIYDRFVFLILLWALLQSIWV 586

  Fly   549 TSIL-----HACMNLTTNEMFNYKRYPYLRDKRGRYQNPFSRGPI-LNLLEFFVCLP-------D 600
            .|::     ..|..:|..| ||.    .:::.:       |.||. |:..|.|...|       |
Yeast   587 ASLIFVQAFQICKGMTNTE-FNV----LMKESK-------SIGPDGLSFNENFNTTPEGFAPSID 639

  Fly   601 RGDD-NDLLL 609
            .|:: ||.:|
Yeast   640 PGEESNDTVL 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738	52/197 (26%)
		ANK repeat	148..181	CDD:293786	7/32 (22%)
		ANK repeat	187..214	CDD:293786	10/26 (38%)
		ANK repeat	216..247	CDD:293786	7/30 (23%)
		ANK repeat	249..280	CDD:293786	10/35 (29%)
		ANK repeat	282..314	CDD:293786	8/31 (26%)
		Ank_4	283..336	CDD:316185	14/64 (22%)
		DHHC	455..567	CDD:334580	39/142 (27%)
AKR1	NP_010550.1	ANK repeat	75..101	CDD:293786	9/48 (19%)
		ANKYR	78..270	CDD:223738	57/225 (25%)
		ANK repeat	103..140	CDD:293786	8/47 (17%)
		ANK repeat	142..173	CDD:293786	10/30 (33%)
		ANK repeat	213..244	CDD:293786	10/30 (33%)
		ANK repeat	246..271	CDD:293786	7/25 (28%)
		COG5273	363..725	CDD:227598	69/315 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I2290
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2373
OMA	1	1.010	-	-		QHG54696
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101007
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R35
SonicParanoid	1	1.000	-	-		X628
TreeFam	0	0.000	Not matched by this tool.
	8	7.700