DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patsas and Zdhhc2

DIOPT Version :9

Sequence 1:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_848482.1	Gene:	Zdhhc2 / 70546	MGIID:	1923452	Length:	366	Species:	Mus musculus

Alignment Length:	314	Identity:	74/314 - (23%)
Similarity:	118/314 - (37%)	Gaps:	93/314 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 GEVKKKSR----WIPSVSESWGWLFGGAGDSKGPLFLFLFSVLLWGYPMYMIRAIPITWNILRRS 398
            |.|:::.|    |||.|                    |:..:|.|.|..|.|:...::...:...
Mouse     7 GGVRRRCRRVLYWIPVV--------------------FISLLLGWSYYAYAIQLCIVSMENIGEQ 51

  Fly   399 HYCFI------------YWNAV----------MWISWA---IANRRDPGYIPLSSDAYYRAIKQI 438
            ..|.:            ||..:          ..:|:|   :..|...|  ....:...||.|.:
Mouse    52 VVCLMAYHLLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKELLEREPRG--EAHQEVLRRAAKDL 114

  Fly   439 PYFDKLKKRNVMLTRLCHSCRCLRPLRAKHCRVCNRCVSYFDHHCPFIYNCVGLRNRMWFFLFVL 503
            |.:.:.....:   |.|..|:.::|.|..||.||::|:...|||||::.||||..|..:|.||:
Mouse   115 PIYTRTMSGAI---RYCDRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFL- 175

  Fly   504 SVAVNCSFTIYFACYCVMIEGFTMLYVL-----GL--------IEAVVFCGLGWILTCTSIL-HA 554
                     .|...||:.|....:.|.:     ||        |..:.|....:.::.:|:. :.
Mouse   176 ---------AYSLLYCLFIAATDLQYFIRFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSSLFGYH 231

  Fly   555 C----MNLTTNEMFNYKRYPYLRDKRGRYQNPFSRGPILNLLEFFVCLPDRGDD 604
            |    .|.:|.|.|   |.|..|  .|..:|.||.|...|:.:.|      ||:
Mouse   232 CWLVSKNKSTLEAF---RNPVFR--HGTDKNGFSLGFSKNMRQVF------GDE 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738
		ANK repeat	148..181	CDD:293786
		ANK repeat	187..214	CDD:293786
		ANK repeat	216..247	CDD:293786
		ANK repeat	249..280	CDD:293786
		ANK repeat	282..314	CDD:293786
		Ank_4	283..336	CDD:316185
		DHHC	455..567	CDD:334580	37/129 (29%)
Zdhhc2	NP_848482.1	DHHC	126..247	CDD:366691	38/133 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..366
		Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000269\|PubMed:21471008	298..366
		Non-canonical dileucine endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	334..335
		NPxY-like endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	357..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810