DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patsas and ZDHHC3

DIOPT Version :9

Sequence 1:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_016862050.1	Gene:	ZDHHC3 / 51304	HGNCID:	18470	Length:	378	Species:	Homo sapiens

Alignment Length:	220	Identity:	56/220 - (25%)
Similarity:	102/220 - (46%)	Gaps:	35/220 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 IMLAQAHQHQDVVRLLYGEVKKKSRWIP-----SVSESWGWLFGGAGDSKGPLFLFLFSVLLWGY 380
            :||...|..:::.|  ..|..:..:.:|     .|...| ::..|.|.:...:..||  ||...:
Human     1 MMLIPTHHFRNIER--KPEYLQPEKCVPPPYPGPVGTMW-FIRDGCGIACAIVTWFL--VLYAEF 60

  Fly   381 PMYMIRAIP---ITWNILRRSHYCFIYWNAVMWISWAI---ANRRDPGYIPLSSDAYYRAIKQIP 439
            .:..:..||   ..::|:..     |.:|.:.:::.|.   |...|||.:|..:     |.|:
Human    61 VVLFVMLIPSRDYVYSIING-----IVFNLLAFLALASHCRAMLTDPGAVPKGN-----ATKE-- 113

  Fly   440 YFDKLKKRNVMLTRLCHSCRCLRPLRAKHCRVCNRCVSYFDHHCPFIYNCVGLRNRMWFFLFVLS 504
            :.:.|:.:...:...|..|..::|.||.||.||.||:...|||||::.||||..|:.:|.||.:.
Human   114 FIESLQLKPGQVVYKCPKCCSIKPDRAHHCSVCKRCIRKMDHHCPWVNNCVGENNQKYFVLFTMY 178

  Fly   505 VAVNCSFTIYFACYCVMIEGFTMLY 529
            :|:       .:.:.:::.||..|:
Human   179 IAL-------ISLHALIMVGFHFLH 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738
		ANK repeat	148..181	CDD:293786
		ANK repeat	187..214	CDD:293786
		ANK repeat	216..247	CDD:293786
		ANK repeat	249..280	CDD:293786
		ANK repeat	282..314	CDD:293786
		Ank_4	283..336	CDD:316185	4/14 (29%)
		DHHC	455..567	CDD:334580	28/75 (37%)
ZDHHC3	XP_016862050.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810