DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patsas and ZDHHC9

DIOPT Version :9

Sequence 1:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001008223.1	Gene:	ZDHHC9 / 51114	HGNCID:	18475	Length:	364	Species:	Homo sapiens

Alignment Length:	322	Identity:	85/322 - (26%)
Similarity:	132/322 - (40%)	Gaps:	99/322 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 VKKKSRWIPSVSESWGWLFGG----------AGDSKGPLFLFLFSV-----LLWGY-----PMYM 384
            |:||      |:..|..|.|.          ....||..:|.||.:     |.:.:     .:.:
Human     6 VRKK------VTRKWEKLPGRNTFCCDGRVMMARQKGIFYLTLFLILGTCTLFFAFECRYLAVQL 64

  Fly   385 IRAIPITWNILRRSHYCFIYWNAVMWISWAIANRRDPGYIP-----------LSSDAYYRAIKQ- 437
            ..|||:...:|      |::..|.:    ...:..|||.||           :..:|...|:.|
Human    65 SPAIPVFAAML------FLFSMATL----LRTSFSDPGVIPRALPDEAAFIEMEIEATNGAVPQG 119

  Fly   438 ---IPYFDKLKKRN-VMLTRLCHSCRCLRPLRAKHCRVCNRCVSYFDHHCPFIYNCVGLRNRMWF 498
               .|.....:..| ::..:.|::|:..||.||.||.:|:.||..||||||::.||||.||..:|
Human   120 QRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSICDNCVERFDHHCPWVGNCVGKRNYRYF 184

  Fly   499 FLFVLSVAVNCSFTIYFACYCVMIEGFTMLYV------LGLIEA----------VVFCGLG-WIL 546
            :||:||:::   .|||       :..|.::||      :|.:|.          |:.|... |.:
Human   185 YLFILSLSL---LTIY-------VFAFNIVYVALKSLKIGFLETLKETPGTVLEVLICFFTLWSV 239

  Fly   547 TCTSILH---ACMNLTTNEMFNYKRYPYLRDKRG------RYQNPFSRGPILNLLEFFVCLP 599
            ...:..|   ..:|.||||           |.:|      |.|||:|.|.|:......:|.|
Human   240 VGLTGFHTFLVALNQTTNE-----------DIKGSWTGKNRVQNPYSHGNIVKNCCEVLCGP 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738
		ANK repeat	148..181	CDD:293786
		ANK repeat	187..214	CDD:293786
		ANK repeat	216..247	CDD:293786
		ANK repeat	249..280	CDD:293786
		ANK repeat	282..314	CDD:293786
		Ank_4	283..336	CDD:316185
		DHHC	455..567	CDD:334580	45/131 (34%)
ZDHHC9	NP_001008223.1	DHHC	138..261	CDD:396215	46/143 (32%)
ZDHHC9	NP_001008223.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..364
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810