DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Patsas and Zdhhc17

DIOPT Version :10

Sequence 1:NP_001356957.1 Gene:Patsas / 34634 FlyBaseID:FBgn0029137 Length:613 Species:Drosophila melanogaster
Sequence 2:NP_766142.2 Gene:Zdhhc17 / 320150 MGIID:2445110 Length:632 Species:Mus musculus


Alignment Length:602 Identity:160/602 - (26%)
Similarity:256/602 - (42%) Gaps:141/602 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 EDHENVLLFEGLDGATTVSLDDIFDIIK---NGEVSEVENLVDKFGMECLSARDRHGYTPAHWIA 157
            :.|.|....|.|...|.:.....:||:|   .|.......||:. |.: :...|:...|..||.|
Mouse    36 QSHYNHGYGEPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEA-GYD-VRQPDKENVTLLHWAA 98

  Fly   158 LNGNVQLMRYLIERTAPIDLPCLGTQGPRPIHWACRKGHASVVQVLLQAGVAVNAADFKGLTPLH 222
            :|..:.|::|.|.:.|.:| ...|.....|:|||.|:||.|:|..|::.|...:..|.:|.:.:|
Mouse    99 INNRIDLVKYYISKGAIVD-QLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIH 162

  Fly   223 LACMYGRTATAAYLLGMGALNNLTDINGDTALHWAAYKGHA-DLMRLLMYSGVELQKTDNF-GST 285
            ||..:|.|:..|||:..|...::.|.||.|.|.||||:.|: |..|||:...|.:...|.: .:|
Mouse   163 LAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNT 227

  Fly   286 PLHLACLSGNMTCVRLLCE------------KSQLDLEPRDKNGKTPIMLAQAHQ-----HQDVV 333
            .||.|.|:||.|.:.||.|            :|.|||..:.||......|.:|.|     :...:
Mouse   228 ALHWAVLAGNTTVISLLLEAGGNVDAQNVKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFL 292

  Fly   334 RLLYGEVKKKSR----------WIPSV-----SESW---GWLFGG---------------AGDSK 365
            |.|..:.:.:.:          |:...     .:||   |.::||               :..|.
Mouse   293 RKLKADKEFRQKVMLGTPFLVIWLVGFIADLDIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSA 357

  Fly   366 GPLFLFLFSVLLWGYPMYMIRAIPITWNILRRSHYCFIYWNAVMWI------------------- 411
            .||.::| :...|.|         :||        .|.:||.:.::                   
Mouse   358 LPLGIYL-ATKFWMY---------VTW--------FFWFWNDLNFLFIHLPFLANSVALFYNFGK 404

  Fly   412 SWAIANRRDPGYIPLSSDAYYRAIKQIPYFDKLKKRNVMLTRLCHSCRCLRPLRAKHCRVCNRCV 476
            ||    :.|||.|..:.:...:.|.::.....|.     |:..|.:|...:|:|:|||.|||||:
Mouse   405 SW----KSDPGIIKATEEQKKKTIVELAETGSLD-----LSIFCSTCLIRKPVRSKHCGVCNRCI 460

  Fly   477 SYFDHHCPFIYNCVGLRNRMWF--FLFVLSVAVNCSFTIYFACY----CVMI-----------EG 524
            :.||||||::.||||..|..:|  :||         |.::..|:    ||..           :|
Mouse   461 AKFDHHCPWVGNCVGAGNHRYFMGYLF---------FLLFMICWMIYGCVSYWGLHCETTYTKDG 516

  Fly   525 F-----------TMLYVLGLIEAVVFCGLGWILTCTSILHACMNLTTNEMFNYKRYPYLRDKRGR 578
            |           ..::.:.|.....|..:..:|.|......|:.:||||..|.:||.:.:.....
Mouse   517 FWTYITQIATCSPWMFWMFLNSVFHFLWVAVLLMCQLYQITCLGITTNERMNARRYKHFKVTTTS 581

  Fly   579 YQNPFSRGPILNLLEFF 595
            .::||:.|.:.|:::||
Mouse   582 IESPFNHGCVRNIIDFF 598

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PatsasNP_001356957.1 ANKYR 99..343 CDD:440430 83/265 (31%)
ANK repeat 148..181 CDD:293786 10/32 (31%)
ANK repeat 187..214 CDD:293786 11/26 (42%)
ANK repeat 216..247 CDD:293786 10/30 (33%)
ANK repeat 249..280 CDD:293786 14/31 (45%)
ANK repeat 282..314 CDD:293786 15/44 (34%)
DHHC 453..567 CDD:396215 42/141 (30%)
Zdhhc17NP_766142.2 Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000269|PubMed:25253725 11..305 84/271 (31%)
ANKYR 52..307 CDD:440430 79/257 (31%)
ANK repeat 89..120 CDD:293786 10/31 (32%)
ANK repeat 122..154 CDD:293786 11/31 (35%)
ANK repeat 156..187 CDD:293786 10/30 (33%)
ANK repeat 189..221 CDD:293786 14/31 (45%)
ANK repeat 224..255 CDD:293786 11/30 (37%)
DHHC 438..568 CDD:396215 41/138 (30%)

Return to query results.
Submit another query.