DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patsas and ZDHHC23

DIOPT Version :9

Sequence 1:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001307395.1	Gene:	ZDHHC23 / 254887	HGNCID:	28654	Length:	435	Species:	Homo sapiens

Alignment Length:	335	Identity:	75/335 - (22%)
Similarity:	118/335 - (35%)	Gaps:	115/335 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 SWGWLFGGAGDSKGPLF---------------LFLFSVLLW--GYPMYMI--------RAIPITW 392
            ||.:|.|....:..|:.               ||..|:.|:  ||..|:.        |..|:..
Human   107 SWHFLLGVVVLTSLPVLALWYYYLTHRRKEQTLFFLSLGLFSLGYMYYVFLQEVVPKGRVGPVQL 171

  Fly   393 NILRRSHYCFIYWNAVMWISWAIAN-RRDPGYI--PLSSDAYYRAI----------------KQI 438
            .:|.    |.::     .|..|:.. :::|||:  |.|.|   |::                |..
Human   172 AVLT----CGLF-----LILLALHRAKKNPGYLSNPASGD---RSLSSSQLECLSRKGQEKTKGF 224

  Fly   439 PYFDKLKKRNVMLTR--------------------LCHSCRCLRPLRAKHCRVCNRCVSYFDHHC 483
            |..|.....|...|:                    .|..|:.:||.||.|||:|..||...||||
Human   225 PGADMSGSLNNRTTKDDPKGSSKMPAGSPTKAKEDWCAKCQLVRPARAWHCRICGICVRRMDHHC 289

  Fly   484 PFIYNCVGLRNRMWFFL----FVLSVAVNCSFTIYFAC----------YCVMIE-------GFTM 527
            .:|.:|||..|...|.|    |:|:.....:.|:...|          ||..:.       .||.
Human   290 VWINSCVGESNHQAFILALLIFLLTSVYGITLTLDTICRDRSVFTALFYCPGVYANYSSALSFTC 354

  Fly   528 LYVLGLIEAVVFCGLGWILTCTSILHACMNLTTNEMFNYKRYPYLRDKRGRY--------QNPFS 584
            ::    ...::..|:.:|. ...:::...|:|..|:     ...||.|.||.        ...::
Human   355 VW----YSVIITAGMAYIF-LIQLINISYNVTEREV-----QQALRQKTGRRLLCGLIVDTGQYN 409

  Fly   585 RGPILNLLEF 594
            ||.:.|..:|
Human   410 RGFLRNWHQF 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738
		ANK repeat	148..181	CDD:293786
		ANK repeat	187..214	CDD:293786
		ANK repeat	216..247	CDD:293786
		ANK repeat	249..280	CDD:293786
		ANK repeat	282..314	CDD:293786
		Ank_4	283..336	CDD:316185
		DHHC	455..567	CDD:334580	36/132 (27%)
ZDHHC23	NP_001307395.1	MerC	96..>151	CDD:281231	9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..255		5/39 (13%)
		zf-DHHC	258..384	CDD:279823	35/130 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810