DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patsas and unc-44

DIOPT Version :9

Sequence 1:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001367345.1	Gene:	unc-44 / 177366	WormBaseID:	WBGene00006780	Length:	6994	Species:	Caenorhabditis elegans

Alignment Length:	389	Identity:	99/389 - (25%)
Similarity:	147/389 - (37%)	Gaps:	123/389 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VAEEDGHAHADDIHLDH--------RPHSPPLTGRGTDGGHGSS--GVEDHENVLLFEG--LDGA 110
            :|...||.:...:.|:.        |.:..||        |.::  |..:..|:||..|  :|..
Worm   233 IAAHYGHENVGQLLLEKGANVNYQARHNISPL--------HVATKWGRTNMANLLLSRGAIIDSR 289

  Fly   111 TTVSLDDIFDIIKNGEVSEVENLVDKFGMECLSARDRHGYTPAHWIALNGNVQLMRYLIERTAPI 175
            |...|..:....::|....|:.||.:...  :||:.::|..|.|..|...:|...|.|:...||:
Worm   290 TKDLLTPLHCAARSGHDQVVDLLVVQGAP--ISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPV 352

  Fly   176 D-------------LPC------------------LGTQGPRPIHWACRKGHASVVQVLLQAGVA 209
            |             ..|                  ....|..|:|.||:|....||::||:...|
Worm   353 DDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAA 417

  Fly   210 VNAADFKGLTPLHLACMYGRTATAAYLLGMGALNNLTDINGDTALHWAAYKGHADLMRLLMYSGV 274
            :.|....||||||:|...|......|||..||..::..:.|:|.||.||.....|::|:|:.:|.
Worm   418 IEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGA 482

  Fly   275 -------ELQ----------------------------KTDNF---------------------- 282
                   |||                            ..||:
Worm   483 KVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHN 547

  Fly   283 ---------GSTPLHLACLSGNMTCVRLLCEK-SQLDLEPRDKNGKTPIMLAQAHQHQDVVRLL 336
                     |.||||||...||:..||||.|: :.:|:|  .||..||:.:| ||.:.|.|.:|
Worm   548 ADKTLLTKKGFTPLHLASKYGNLEVVRLLLERGTPVDIE--GKNQVTPLHVA-AHYNNDKVAML 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738	72/290 (25%)
		ANK repeat	148..181	CDD:293786	11/63 (17%)
		ANK repeat	187..214	CDD:293786	11/26 (42%)
		ANK repeat	216..247	CDD:293786	13/30 (43%)
		ANK repeat	249..280	CDD:293786	13/65 (20%)
		ANK repeat	282..314	CDD:293786	16/63 (25%)
		Ank_4	283..336	CDD:316185	25/53 (47%)
		DHHC	455..567	CDD:334580
unc-44	NP_001367345.1	ANK repeat	32..63	CDD:293786
		PHA03095	37..>387	CDD:222980	33/163 (20%)
		ANK repeat	65..96	CDD:293786
		ANK repeat	98..129	CDD:293786
		ANK repeat	131..156	CDD:293786
		ANK repeat	197..224	CDD:293786
		ANK repeat	226..257	CDD:293786	4/23 (17%)
		PHA02876	<242..>648	CDD:165207	96/380 (25%)
		ANK repeat	259..290	CDD:293786	9/38 (24%)
		ANK repeat	292..322	CDD:293786	6/31 (19%)
		ANK repeat	325..356	CDD:293786	10/30 (33%)
		ANK repeat	358..389	CDD:293786	1/30 (3%)
		ANK repeat	391..422	CDD:293786	12/30 (40%)
		ANK repeat	424..455	CDD:293786	13/30 (43%)
		ANK repeat	457..488	CDD:293786	10/30 (33%)
		ANK repeat	490..519	CDD:293786	3/28 (11%)
		ANK repeat	523..552	CDD:293786	2/28 (7%)
		Ank_2	555..>780	CDD:423045	26/57 (46%)
		ANK repeat	556..586	CDD:293786	15/29 (52%)
		ANK repeat	589..620	CDD:293786	9/21 (43%)
		ANK repeat	622..652	CDD:293786
		ANK repeat	655..685	CDD:293786
		ANK repeat	688..719	CDD:293786
		ANK repeat	721..752	CDD:293786
		ANK repeat	754..784	CDD:293786
		Ank_4	756..807	CDD:372654
		ZU5	1008..1110	CDD:128514
		UPA_2	1337..1472	CDD:375346
		Death_ank	1503..1580	CDD:260029
		PTZ00449	<1770..2112	CDD:185628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910