DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patsas and si:ch211-223a10.1

DIOPT Version :9

Sequence 1:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_009305694.1	Gene:	si:ch211-223a10.1 / 101884554	ZFINID:	ZDB-GENE-090313-86	Length:	544	Species:	Danio rerio

Alignment Length:	542	Identity:	133/542 - (24%)
Similarity:	220/542 - (40%)	Gaps:	99/542 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 VSLDDIFDIIKNGEVSEVENLVDKFGMECLSARDRHGYTPAHWIALNGNVQLMRYLIERTAPIDL 177
            ||...||:.::.||:..|.:|:.: ....|..:...|:|..|:.|||||..:...|:...|..::
Zfish     4 VSGSCIFESVQRGEIDRVSHLLQQ-DRGVLKQKGWGGFTALHFAALNGNRAVAELLLNSGADPNI 67

  Fly   178 PCLGTQGPRPIHWACRKGHASVVQVLLQAGVAVNAADFKGLTPLHLACMYGRTATAAYLLGMGAL 242
            ||  ..|..|.|:|||.|:..::..::|.|..:..||.:|.|.||.|...|......||......
Zfish    68 PC--DAGQTPFHFACRNGNIYIMYKMMQQGADLRIADEQGKTALHYAVSGGSVIATQYLWETRMF 130

  Fly   243 NNLTDINGD-TALHWAAYKGHADLMR-LLMYSGVELQKTDNFGSTPLHLACLSGNMTCVRLLCEK 305
            :.....|.. |.||.||..|:.|::| ||..:....:..|:.|:|.||:|...|.:....||.:.
Zfish   131 HFSDPDNYQVTPLHLAASTGNTDVVRYLLRANRCSPEAVDHQGATALHVAAEKGMIEVCWLLLKS 195

  Fly   306 SQLD-LEPRDKNGKTPIML---AQAHQHQDVVRLLYGEVKKKSRWIPSVS-ESWGWL-------- 357
            :.|. |...:..|.||:.|   ....:||.:.::|....::....||..| ..:.|:
Zfish   196 AGLHILHMTNHTGLTPLDLCNQGNTFRHQQLSKILTDFSQQPKNLIPKDSYVMYFWMLLLPSLSG 260

  Fly   358 ------------FGGAGDSKGPLFLFLFSVLLWGY-----------PMY---------------M 384
                        :||.  ....||.|:...:|..|           |:|               :
Zfish   261 VAVLVIAAALGEYGGI--FSAVLFPFMAKTILSQYHRLSSFQRLPNPVYLGTLTAGLIHSTVCFL 323

  Fly   385 IRAIPITWNILRRSHYCFIYWNAVMWISWAIANRRDPGYI-PLSSDAYYRAIKQIPYFDKLKKRN 448
            .:.||..|......|...:::..:..:.|.:. ::.||.: ...:|:.:.:|      ..|.:..
Zfish   324 YKIIPSFWPAHTLLHLSLVHFCVLAGLFWKVL-KQSPGQLKDADTDSRFSSI------GDLMEAG 381

  Fly   449 VMLTRLCHSCRCLRPLRAKHCRVCNRCVSYFDHHCPFIYNCVGLRNRMWFFLFVLSVA------- 506
            ....|.|..|..::....||||:|:.|:..:||||.||..|||..|...|.||::|:.
Zfish   382 QSPDRFCIYCELIQVENCKHCRLCDMCIKDYDHHCLFINQCVGRENHRTFILFLMSMVMAHLIFI 446

  Fly   507 VNCSFTIYFACYCVMIEGFTM------------LYVLGLIEAVVFCGLGWILTCTSILHACMNLT 559
            ::..|.:|     :.:.|..:            :.:|.|:..:....:||:|  ...|.|....|
Zfish   447 LSAIFYLY-----LKVSGLQLSDWGSVAGREAWVLLLTLLNLLSLFWVGWLL--GEQLDAISRGT 504

  Fly   560 TNEMFNYKRY----PYLRDKRG 577
            |.   .|:||    |..|.:.|
Zfish   505 TT---YYRRYDLKGPSKRQRLG 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738	60/194 (31%)
		ANK repeat	148..181	CDD:293786	12/32 (38%)
		ANK repeat	187..214	CDD:293786	8/26 (31%)
		ANK repeat	216..247	CDD:293786	8/30 (27%)
		ANK repeat	249..280	CDD:293786	11/32 (34%)
		ANK repeat	282..314	CDD:293786	10/32 (31%)
		Ank_4	283..336	CDD:316185	16/56 (29%)
		DHHC	455..567	CDD:334580	34/130 (26%)
si:ch211-223a10.1	XP_009305694.1	ANK repeat	7..36	CDD:293786	7/29 (24%)
		Ank_2	9..102	CDD:289560	28/95 (29%)
		ANK	39..159	CDD:238125	40/121 (33%)
		ANK repeat	39..69	CDD:293786	10/29 (34%)
		ANK repeat	71..102	CDD:293786	9/30 (30%)
		Ank_2	76..162	CDD:289560	28/85 (33%)
		ANK repeat	138..170	CDD:293786	10/31 (32%)
		Ank_4	139..192	CDD:290365	17/52 (33%)
		zf-DHHC	384..509	CDD:279823	35/134 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54696
OrthoDB	1	1.010	-	-		D213306at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830