DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patsas and LOC100498452

DIOPT Version :9

Sequence 1:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_017951631.1	Gene:	LOC100498452 / 100498452	-ID:	-	Length:	566	Species:	Xenopus tropicalis

Alignment Length:	500	Identity:	212/500 - (42%)
Similarity:	295/500 - (59%)	Gaps:	16/500 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 IFDIIKNGEVSEVENLVDKFGMECLSARDRHGYTPAHWIALNGNVQLMRYLIERTAPIDLPCLGT 182
            ||..:|.|.:.:.:::::......|...|..|:||.||.||.|::|||...::...|:|.|.|..
Frog    70 IFQAVKEGNIKKCQHILEAESAAVLGCYDEKGHTPVHWAALTGSIQLMELFVDSKGPVDTPSLAE 134

  Fly   183 QGPRPIHWACRKGHASVVQVLLQAGVAVNAADFKGLTPLHLACMYGRTATAAYLLGMGALNNLTD 247
            .|..|||||...|..:||.:||:|||:|:..|.||.|||..|..||:||...||:|.||..||.|
Frog   135 LGQHPIHWAAVSGSIAVVDILLKAGVSVDVKDQKGCTPLITAAQYGQTALCCYLIGKGAKINLYD 199

  Fly   248 INGDTALHWAAYKGHADLMRLLMYSGVELQKTDNFGSTPLHLACLSGNMTCVRLLCEKSQLDLEP 312
            ..|||||||||:|||.:|..||:|||...::|||||.||||||.||||:..|:||||:..:|||.
Frog   200 SEGDTALHWAAFKGHCELSHLLIYSGCNPRQTDNFGQTPLHLAVLSGNLPTVQLLCEQDNIDLEG 264

  Fly   313 RDKNGKTPIMLAQAHQHQDVVRLLYGEV--KKKSRWIPSVSESWG-WLFGGAGDSKGPLFLFLFS 374
            .|.|..||:.||...:..|:...|...:  .||..    ...:|. ||||..|.:|||:..|..:
Frog   265 EDNNRNTPLKLANGRKSWDIASFLQSTIIQSKKHH----AKFNWSTWLFGRPGKTKGPILFFFGN 325

  Fly   375 VLLWGYPMYMIRAIPITWNILRRSHYCFIYWNAVMWISWAIANRRDPGYIPLSSDAYYRAIKQIP 439
            :.|||||.|..:.:|:::..|...|..|:..|.:||..:..|:..|||::|..::.|..|:||..
Frog   326 LFLWGYPTYFFKIVPVSYYALWELHMMFLLCNTLMWAFFLKASHMDPGFLPQDTEEYKYAVKQAI 390

  Fly   440 YFDKLKKRNVMLTRLCHSCRCLRPLRAKHCRVCNRCVSYFDHHCPFIYNCVGLRNRMWFFLFVLS 504
            ..:..|.....|.||||:|..::|||:||||:.|||||:|||:||:|||.||.|||.:|..|::|
Frog   391 NCNDWKDGKNPLNRLCHTCHLVKPLRSKHCRITNRCVSHFDHYCPYIYNDVGKRNRAFFVGFLVS 455

  Fly   505 VAVNCSFTIYFACYCVMIEGFTMLYVLGLIEAVVFCGLGWILTCTSILHACMNLTTNEMFNYKRY 569
            :.:.|...:|....|..|.|.::|..:|.|...|...:..:::...:..|.:|:||||..|.|:|
Frog   456 MCMCCFIGVYLCWDCFYIVGNSILIGIGFIFLSVIGTISALMSVMCLYMAIVNITTNERMNVKKY 520

  Fly   570 PYLRDKRGRYQNPFSRGPILNLLEFF-VCLPDRGDDNDLLLEDNI 613
            .||:|.||.::|||.||..||||||. :..|        |.||.|
Frog   521 TYLKDDRGHFRNPFDRGFYLNLLEFIDIVAP--------LSEDKI 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738	93/187 (50%)
		ANK repeat	148..181	CDD:293786	14/32 (44%)
		ANK repeat	187..214	CDD:293786	14/26 (54%)
		ANK repeat	216..247	CDD:293786	17/30 (57%)
		ANK repeat	249..280	CDD:293786	18/30 (60%)
		ANK repeat	282..314	CDD:293786	20/31 (65%)
		Ank_4	283..336	CDD:316185	26/52 (50%)
		DHHC	455..567	CDD:334580	47/111 (42%)
LOC100498452	XP_017951631.1	Ank_2	70..166	CDD:372319	36/95 (38%)
		ANK repeat	101..133	CDD:293786	14/31 (45%)
		ANK repeat	136..166	CDD:293786	15/29 (52%)
		ANKYR	<139..269	CDD:223738	75/129 (58%)
		ANK repeat	168..199	CDD:293786	17/30 (57%)
		ANK repeat	201..226	CDD:293786	17/24 (71%)
		DHHC	399..516	CDD:366691	49/116 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6294
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H121926
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1701
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D213306at33208
OrthoFinder	1	1.000	-	-		FOG0009984
OrthoInspector	1	1.000	-	-		oto104573
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060