DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patsas and zdhhc13

DIOPT Version :9

Sequence 1:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_002942880.3	Gene:	zdhhc13 / 100493145	XenbaseID:	XB-GENE-997024	Length:	612	Species:	Xenopus tropicalis

Alignment Length:	652	Identity:	153/652 - (23%)
Similarity:	254/652 - (38%)	Gaps:	179/652 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 SSSCNMVVAEEDGHAHADDIHLDHRPHSPPLTGRGTDGGHGSSG---------VEDHENVLLFEG 106
            ||.|.:    ..||:|      .|..|.           ||.:.         .||:.|
Frog     3 SSPCKL----PHGHSH------QHSHHH-----------HGGTEEEKAAVPHVAEDYSN------ 40

  Fly   107 LDGATTVSLDDIFDIIK---NGEVSEVENLVDKFGMECLSARDRHGYTPAHWIALNGNVQLMRYL 168
                        :||:|   :|.:.....|||. |.: :...|:...|..||.|:|..::|::|.
Frog    41 ------------WDIVKATQHGMLERCRELVDA-GYD-VRQPDKENVTLLHWAAINNRLELVKYF 91

  Fly   169 IERTAPIDLPCLGTQGPRPIHWACRKGHASVVQVLLQAGVAVNAADFKGLTPLHLACMYGRTATA 233
            |.:.|.:| ...||....|:|||.|:||..:|.:|::.|......|.:|.:.:|||.::......
Frog    92 ISKGAIVD-QLGGTLNSTPLHWAIRQGHLQMVILLIKCGADPTLIDGEGYSSVHLAVLFQHLPII 155

  Fly   234 AYLLGMGALNNLTDING-----------------------------------DTALHWAAYKGHA 263
            |||:..|...:..|:||                                   :||||||...|:|
Frog   156 AYLVSKGQSIDSPDMNGMTPLMLSAHRIIGMEPTNFLLKLNPSIHAADKVHRNTALHWAVTSGNA 220

  Fly   264 DLMRLLMYSGVELQKTDNFGSTPLHLACLSGNMTCVRLLCEKSQLDLEPRDKNGKTPIMLAQAHQ 328
            :.:.||:.:|..|...:..|.|||.:|..:.|...|.:|..::|:    |.:.....:...|.::
Frog   221 NAVDLLLEAGSNLDAVNAKGETPLEIARQTRNRLTVHILASEAQM----RSRRSSRIMKALQRYE 281

  Fly   329 HQDVVRLLYGEVKKKSRWIPSVSESWGWLFGGAGDSKGPLFLFLFSVLLWGYPMYMIRAIPITWN 393
            ...|..::...:......:...::|  ||..|.          |.:::..|..::..|.|...
Frog   282 ITFVTLMVLLIIWAVGYVLDMNTDS--WLLKGT----------LLALVTAGSQLFARRFIGCK-- 332

  Fly   394 ILRRS-----HYCFIYWNAVMWI-----------------------------SWAIANRRDPGYI 424
             .:||     ..|.|:|..:.|.                             :|.    .|||||
Frog   333 -SQRSLPAIIFSCCIFWMFLTWFIYFLPGLARVAFQLPFIISMLLLFYFFYKTWC----TDPGYI 392

  Fly   425 PLSSDAYYRAIKQIPYFDKLKKRNVMLTRL-CHSCRCLRPLRAKHCRVCNRCVSYFDHHCPFIYN 488
            ..|.:...:.|      ..|.:...:..|| |.||...:|||:.||..||.||:.||.||.:...
Frog   393 KSSEEESRQTI------ITLAEAGCLDARLFCTSCLVKKPLRSMHCHACNSCVARFDQHCVWTGQ 451

  Fly   489 CVGLRNRMWFFLFVLSVAVNCSF-----TIYFACYCVMIEGFTMLYVLGLIEAVVFCGLGWILTC 548
            |:|..|:.:|.||:.|:||..::     ::|::.:|.|  |.....:...:..:|.|. .|:|..
Frog   452 CIGAGNQHFFVLFLASLAVVGNWMIYATSVYWSDHCGM--GSRKDGIWATLSQIVNCS-PWVLYI 513

  Fly   549 TSILHA-----------------CMNLTTNEMFNYK-RYPYLRDKRGRYQNPFSRGPILNLLEFF 595
            ..::.|                 .:.|||.|..:.: :..:|:.:....:.||:||.:.||.:||
Frog   514 FCLVSAFTVWATLMLLVQLFQISFLGLTTQERISLQVQNRHLKHQVSLRRTPFNRGCLQNLADFF 578

  Fly   596 VC 597
            .|
Frog   579 HC 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738	63/230 (27%)
		ANK repeat	148..181	CDD:293786	10/32 (31%)
		ANK repeat	187..214	CDD:293786	10/26 (38%)
		ANK repeat	216..247	CDD:293786	8/30 (27%)
		ANK repeat	249..280	CDD:293786	14/65 (22%)
		ANK repeat	282..314	CDD:293786	9/31 (29%)
		Ank_4	283..336	CDD:316185	12/52 (23%)
		DHHC	455..567	CDD:334580	38/133 (29%)
zdhhc13	XP_002942880.3	Ank_2	46..136	CDD:372319	28/92 (30%)
		ANK repeat	71..102	CDD:293786	10/31 (32%)
		PHA03095	82..>246	CDD:222980	46/164 (28%)
		ANK repeat	104..136	CDD:293786	11/31 (35%)
		ANK repeat	138..169	CDD:293786	8/30 (27%)
		ANK repeat	171..237	CDD:293786	14/65 (22%)
		DHHC	327..>549	CDD:388695	57/237 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54696
OrthoDB	1	1.010	-	-		D213306at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930