DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patsas and zdhhc17

DIOPT Version :9

Sequence 1:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_002935687.3	Gene:	zdhhc17 / 100486328	XenbaseID:	XB-GENE-966618	Length:	623	Species:	Xenopus tropicalis

Alignment Length:	637	Identity:	165/637 - (25%)
Similarity:	268/637 - (42%)	Gaps:	173/637 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 HADDI----HLDHRPHSPPLTGRGTDGGHGSSGVEDHENVLLFEGLDGATTVSLDD--IFDIIK- 123
            |.::|    |.:|        |..:|    |.|.:.|                :||  .:||:|
Frog    19 HPEEIKTQSHYNH--------GYSSD----SLGRKSH----------------MDDYSTWDIVKA 55

  Fly   124 --NGEVSEVENLVDKFGMECLSARDRHGYTPAHWIALNGNVQLMRYLIERTAPIDLPCLGTQGPR 186
              .|.......|||. |.: :...|:...|..||.|:|..:.|:::.|.:.|.:| ...|.....
Frog    56 TQYGIYERCRELVDA-GYD-VRQPDKENVTLLHWAAINNRMDLVKFYISKGAIVD-QLGGDLNST 117

  Fly   187 PIHWACRKGHASVVQVLLQAGVAVNAADFKGLTPLHLACMYGRTATAAYLLGMGALNNLTDINGD 251
            |:|||.|:||.|:|..|::.|...:..|.:|.:.:|||..:|.|:..|||:..|...::.|.||.
Frog   118 PLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGM 182

  Fly   252 TALHWAAYKGHA-DLMRLLMYSGVELQKTDNF-GSTPLHLACLSGNMTCVRLLCEKSQLDLEPRD 314
            |.|.||||:.|: |..|||:...|.:...|.: .:|.||.|.|:||.|.:.||.: :..:::.::
Frog   183 TPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLD-AGANVDAQN 246

  Fly   315 KNGKTPIMLAQAHQ------HQDVVRLLYG--------------EVKKKSR--------WIPSV- 350
            ..|::|:.||:..:      |....|...|              |.::|..        |:...
Frog   247 IKGESPLDLAKQRKNVWMINHLQEARQAKGYDNPSFFKKLKADKEFRQKVMLGTPFLVIWLVGFI 311

  Fly   351 ----SESW---GWLFGG---------------AGDSKGPLFLFLFSVLLWGYPMYMIRAIPITWN 393
                .:||   |.::||               :..|..||.::| :...|.|         :||
Frog   312 ADLDIDSWLIKGLMYGGVWAMVQFLSKSFFDHSMHSALPLGIYL-ATKFWMY---------VTW- 365

  Fly   394 ILRRSHYCFIYWNAVMWI-------------------SWAIANRRDPGYIPLSSDAYYRAIKQIP 439
                   .|.:||.:.::                   ||    :.|||.|..:.:...:.|.::.
Frog   366 -------FFWFWNDLSFLFIHLPFLANSFALFYNFGKSW----KSDPGIIKATEEQKKKTIVELA 419

  Fly   440 YFDKLKKRNVMLTRLCHSCRCLRPLRAKHCRVCNRCVSYFDHHCPFIYNCVGLRNRMWF--FLFV 502
            ....|.     |:..|.:|...:|:|:|||.:||||::.||||||::.||||..|..:|  :||.
Frog   420 ETGSLD-----LSIFCSTCLIRKPVRSKHCGICNRCIAKFDHHCPWVGNCVGSGNHRYFMGYLFF 479

  Fly   503 LSVAV-----NCSFTIYFACYC---VMIEGFTMLYVLGLIEAVVFCG-------------LGWI- 545
            |...:     .|  ..|:..:|   ...:||..     .|..:..|.             |.|:
Frog   480 LLCMICWMIYGC--ISYWGIHCDTTYTKDGFWT-----YITQIATCSPWMFWMFLNSVFHLMWVA 537

  Fly   546 --LTCTSILHACMNLTTNEMFNYKRYPYLRDKRGRYQNPFSRGPILNLLEFF 595
              |.|.....:|:.:||||..|.:||.:.:......::||:.|.|.|:::||
Frog   538 VLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCIRNIIDFF 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738	69/199 (35%)
		ANK repeat	148..181	CDD:293786	9/32 (28%)
		ANK repeat	187..214	CDD:293786	11/26 (42%)
		ANK repeat	216..247	CDD:293786	10/30 (33%)
		ANK repeat	249..280	CDD:293786	14/31 (45%)
		ANK repeat	282..314	CDD:293786	10/32 (31%)
		Ank_4	283..336	CDD:316185	16/58 (28%)
		DHHC	455..567	CDD:334580	43/137 (31%)
zdhhc17	XP_002935687.3	PHA02874	<62..>256	CDD:165205	65/197 (33%)
		ANK repeat	80..111	CDD:293786	9/31 (29%)
		ANK repeat	113..145	CDD:293786	11/31 (35%)
		ANK repeat	147..178	CDD:293786	10/30 (33%)
		Ank_2	152..246	CDD:403870	35/94 (37%)
		ANK repeat	180..212	CDD:293786	14/31 (45%)
		ANK repeat	215..246	CDD:293786	10/31 (32%)
		DHHC	429..559	CDD:396215	42/136 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D213306at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R35
SonicParanoid	1	1.000	-	-		X628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040