DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ced-12 and ELMO3

DIOPT Version :9

Sequence 1:	NP_609548.1	Gene:	Ced-12 / 34633	FlyBaseID:	FBgn0032409	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_078988.3	Gene:	ELMO3 / 79767	HGNCID:	17289	Length:	720	Species:	Homo sapiens

Alignment Length:	730	Identity:	310/730 - (42%)
Similarity:	441/730 - (60%)	Gaps:	39/730 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 HIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNEI 76
            ::||||::..|.|.|||.|||..|||:.::|:|:.||::..:.|||||.: .:|:|:||.||.||
Human     6 NVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLTHSERYALQFAD-GHRRYITENNRAEI 69

  Fly    77 KNGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMIE 141
            ||||:|.|..:|...|...:..|.:.||:.:...|:.|..|::|..||.|.|...||..|..:||
Human    70 KNGSILCLSTAPDLEAEQLLGGLQSNSPEGRREALRRLVPLASDMIFAREVISRNGLQILGTIIE 134

  Fly   142 DGGQTNEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYPTNCGESALSNLENIV 206
            ||....| :|..||.:|.||||||.||||.....|| |.:....|......:....||..||::.
Human   135 DGDDLGE-VLALSLRAFSELMEHGVVSWETLSIPFV-RKVVCYVNMNLMDASVPPLALGLLESVT 197

  Fly   207 MCSNK-HVLVAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRRRTIAQTISAKQFRL 270
            :.|.. ..||..::.|..:|..||.:|.. ::..|:|||.||...|....|:.:...:..:..|.
Human   198 LSSPALGQLVKSEVPLDRLLVHLQVMNQQ-LQTKAMALLTALLQGASPVERKHMLDYLWQRNLRQ 261

  Fly   271 ALIGN------GLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQDAHEKIKELRRIAFDDNTNA 329
            .:..|      .:|.||.|.|||||.|.|||||.|||..::...|:..|:::.||:.||:
Human   262 FIYKNIIHSAAPMGDEMAHHLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQVLRQAAFE----- 321

  Fly   330 LNQNDDHIRRGGGSGAG------NVNFSQYYKKLGFKCDINPAQDFIETPPGILALDCMVYFARN 388
                    ..|..||||      ....::.::||||. :.|||||....|||:||||.|:||:||
Human   322 --------VEGESSGAGLSADRRRSLCAREFRKLGFS-NSNPAQDLERVPPGLLALDNMLYFSRN 377

  Fly   389 YTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSGDFQPMFFTHDSPFEEF 453
            ....|::.|.|||.|.|:|||||.|.||:|..:||::||:|||.:|.:.||.||||..|..|.|.
Human   378 APSAYSRFVLENSSREDKHECPFARGSIQLTVLLCELLRVGEPCSETAQDFSPMFFGQDQSFHEL 442

  Fly   454 FCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRNKIALLTYQQITTLRQQ 518
            ||:.:..||:|||:||||.|||.....|||||:.|||..:|.:|:.||.|:..|||.::..|||.
Human   443 FCVGIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQT 507

  Fly   519 ERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLRGTRTKDKFWYARLSPN 583
            ||..:|  .:.|..|::|:||:.|:::.||:||||..|.|||.|.| :...|.:||.|:..||||
Human   508 ERLHQE--GTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFRK-ISSRRRQDKLWFCCLSPN 569

  Fly   584 HKVIHYGDCDE-KTIPTMEELPKKLPISEIKQLLEGKECPHMKET---RIRKSAVNLAFSITFE- 643
            ||::.|||.:| .:.||:|.||::||:::::.||.||:|||::|.   :..|....|||||:::
Human   570 HKLLQYGDMEEGASPPTLESLPEQLPVADMRALLTGKDCPHVREKGSGKQNKDLYELAFSISYDR 634

  Fly   644 NMEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFDTLLSMEIKLRLLDTEGVDISKDP 708
            ..|.:.|:|:||.:..|..||||::||||.||.|:|...|.:.||:||.|||||:.|.|.|.:.|
Human   635 GEEEAYLNFIAPSKREFYLWTDGLSALLGSPMGSEQTRLDLEQLLTMETKLRLLELENVPIPERP 699

  Fly   709 PPIPEDPENYDFCFE 723
            ||:|..|.|::||::
Human   700 PPVPPPPTNFNFCYD 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	DUF3361	122..275	CDD:288674	51/153 (33%)
		ELMO_CED12	296..474	CDD:282570	81/183 (44%)
		PH_ELMO1_CED-12	546..673	CDD:270166	60/131 (46%)
ELMO3	NP_078988.3	DUF3361	116..267	CDD:314671	51/153 (33%)
		ELMO_CED12	292..463	CDD:309737	82/184 (45%)
		PH_ELMO1_CED-12	534..663	CDD:270166	59/129 (46%)
		SH3-binding	696..706		4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	206	1.000	Domainoid score	I2908
eggNOG	1	0.900	-	-		E1_KOG2999
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	622	1.000	Inparanoid score	I876
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177102at33208
OrthoFinder	1	1.000	-	-		FOG0001427
OrthoInspector	1	1.000	-	-		otm41511
orthoMCL	1	0.900	-	-		OOG6_102058
Panther	1	1.100	-	-	O	PTHR12771
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1314
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.830