Protein Alignment Ced-12 and ELMO2

DIOPT Version :10

• Sequence 1: NP_609548.1
• Gene: Ced-12 / 34633
• FlyBaseID: FBgn0032409
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_573403.1
• Gene: ELMO2 / 63916
• HGNCID: 17233
• Length: 720
• Species: Homo sapiens
• Alignment Length: 735
• Identity: 331/735 - (45%)
• Similarity: 477/735 - (64%)
• Gaps: 45/735 - (6%)

  Fly    11 SHIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNE 75
            |.|||:|:|.....|||:.:||:.||||.|:|:|:|||:.:.:.|.|: |....:.|:||:.|::
Human     5 SDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLPNPEYYTLR-YADGPQLYITEQTRSD 68

  Fly    76 IKNGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMI 140
            ||||::|||..|||:.|...||...:.:.:.:...:|||..||.|.|||.|||...|:..|.:::
Human    69 IKNGTILQLAISPSRAARQLMERTQSSNMETRLDAMKELAKLSADVTFATEFINMDGIIVLTRLV 133

  Fly   141 EDGGQT---NEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYP---TNCGESAL 199
            |.|.:.   ..::|.::|.:|:|||:||.|||::...:|:.:    :..:...|   .:..:.:|
Human   134 ESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDMVSITFIKQ----IAGYVSQPMVDVSILQRSL 194

  Fly   200 SNLENIVMCSNK-HVLVAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRRRTIAQTI 263
            :.||::|:.|.. :..:||:|.:..::..|| |::..::..||||:||||:||.|.:|:.:|...
Human   195 AILESMVLNSQSLYQKIAEEITVGQLISHLQ-VSNQEIQTYAIALINALFLKAPEDKRQDMANAF 258

  Fly   264 SAKQFRLALI-----GN-GLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQDAHEKIKELRRIA 322
            :.|..|..::     || .:.|||.|||||||.||..|||:||..||:..||...:.|.||||||
Human   259 AQKHLRSIILNHVIRGNRPIKTEMAHQLYVLQVLTFNLLEERMMTKMDPNDQAQRDIIFELRRIA 323

  Fly   323 FD---DNTNALNQNDDHIRRGGGSGAGNVNFSQYYKKLGFKCDINPAQDFIETPPGILALDCMVY 384
            ||   |.:||         .|.|:......:::.||.|||...||||.||.:||||:||||.|:|
Human   324 FDAESDPSNA---------PGSGTEKRKAMYTKDYKMLGFTNHINPAMDFTQTPPGMLALDNMLY 379

  Fly   385 FARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSGDFQPMFFTHDSP 449
            .|:.:...|.:||.|||.|.|:|||||||::|||.|:||:||::||.|.|...|:.|||||||..
Human   380 LAKVHQDTYIRIVLENSSREDKHECPFGRSAIELTKMLCEILQVGELPNEGRNDYHPMFFTHDRA 444

  Fly   450 FEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRNKIALLTYQQITT 514
            |||.|.||:..||:|||:||||||||:....||||||.|.|..:|.:||.|::|:..|:|.:|..
Human   445 FEELFGICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPNSLDQFKSKLRSLSYSEILR 509

  Fly   515 LRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLRGTRTKDKFWYAR 579
            |||.||.|::  |..:..||:|:|||.|:||||||||||:.|.||:.|.| :...|.:::|||.|
Human   510 LRQSERMSQD--DFQSPPIVELREKIQPEILELIKQQRLNRLCEGSSFRK-IGNRRRQERFWYCR 571

  Fly   580 LSPNHKVIHYGDCDEKTIP----TMEELPKKLPISEIKQLLEGKECPHMKE---TRIRKSAVNLA 637
            |:.||||:||||.|:.  |    |.|.|.:|:|:::||.::.||:||||||   .:..|..:.||
Human   572 LALNHKVLHYGDLDDN--PQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKSALKQNKEVLELA 634

  Fly   638 FSITFENMEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFDTLLSMEIKLRLLDTEGV 702
            |||.::..|  ||:|:||::..:..|.||::||||:.|.|:....|.|||||||:||||||.|.:
Human   635 FSILYDPDE--TLNFIAPNKYEYCIWIDGLSALLGKDMSSELTKSDLDTLLSMEMKLRLLDLENI 697

  Fly   703 DISKDPPPIPEDPENYDFCF 722
            .|.:.|||||::|.:|||.:
Human   698 QIPEAPPPIPKEPSSYDFVY 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	ELMO_ARM	122..277	CDD:463369	51/167 (31%)
		ELMO_CED12	295..477	CDD:461411	99/184 (54%)
		PH_ELMO1_CED-12	546..673	CDD:270166	62/133 (47%)
ELMO2	NP_573403.1	ELMO_ARM	115..272	CDD:463369	49/161 (30%)
		ELMO_CED12	295..474	CDD:461411	99/187 (53%)
		PH_ELMO1_CED-12	539..668	CDD:270166	62/133 (47%)
		SH3-binding	700..707		3/6 (50%)