DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ced-12 and ELMO2

DIOPT Version :9

Sequence 1:	NP_609548.1	Gene:	Ced-12 / 34633	FlyBaseID:	FBgn0032409	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_573403.1	Gene:	ELMO2 / 63916	HGNCID:	17233	Length:	720	Species:	Homo sapiens

Alignment Length:	735	Identity:	331/735 - (45%)
Similarity:	477/735 - (64%)	Gaps:	45/735 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SHIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNE 75
            |.|||:|:|.....|||:.:||:.||||.|:|:|:|||:.:.:.|.|: |....:.|:||:.|::
Human     5 SDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLPNPEYYTLR-YADGPQLYITEQTRSD 68

  Fly    76 IKNGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMI 140
            ||||::|||..|||:.|...||...:.:.:.:...:|||..||.|.|||.|||...|:..|.:::
Human    69 IKNGTILQLAISPSRAARQLMERTQSSNMETRLDAMKELAKLSADVTFATEFINMDGIIVLTRLV 133

  Fly   141 EDGGQT---NEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYP---TNCGESAL 199
            |.|.:.   ..::|.::|.:|:|||:||.|||::...:|:.:    :..:...|   .:..:.:|
Human   134 ESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDMVSITFIKQ----IAGYVSQPMVDVSILQRSL 194

  Fly   200 SNLENIVMCSNK-HVLVAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRRRTIAQTI 263
            :.||::|:.|.. :..:||:|.:..::..|| |::..::..||||:||||:||.|.:|:.:|...
Human   195 AILESMVLNSQSLYQKIAEEITVGQLISHLQ-VSNQEIQTYAIALINALFLKAPEDKRQDMANAF 258

  Fly   264 SAKQFRLALI-----GN-GLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQDAHEKIKELRRIA 322
            :.|..|..::     || .:.|||.|||||||.||..|||:||..||:..||...:.|.||||||
Human   259 AQKHLRSIILNHVIRGNRPIKTEMAHQLYVLQVLTFNLLEERMMTKMDPNDQAQRDIIFELRRIA 323

  Fly   323 FD---DNTNALNQNDDHIRRGGGSGAGNVNFSQYYKKLGFKCDINPAQDFIETPPGILALDCMVY 384
            ||   |.:||         .|.|:......:::.||.|||...||||.||.:||||:||||.|:|
Human   324 FDAESDPSNA---------PGSGTEKRKAMYTKDYKMLGFTNHINPAMDFTQTPPGMLALDNMLY 379

  Fly   385 FARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSGDFQPMFFTHDSP 449
            .|:.:...|.:||.|||.|.|:|||||||::|||.|:||:||::||.|.|...|:.|||||||..
Human   380 LAKVHQDTYIRIVLENSSREDKHECPFGRSAIELTKMLCEILQVGELPNEGRNDYHPMFFTHDRA 444

  Fly   450 FEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRNKIALLTYQQITT 514
            |||.|.||:..||:|||:||||||||:....||||||.|.|..:|.:||.|::|:..|:|.:|..
Human   445 FEELFGICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPNSLDQFKSKLRSLSYSEILR 509

  Fly   515 LRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLRGTRTKDKFWYAR 579
            |||.||.|::  |..:..||:|:|||.|:||||||||||:.|.||:.|.| :...|.:::|||.|
Human   510 LRQSERMSQD--DFQSPPIVELREKIQPEILELIKQQRLNRLCEGSSFRK-IGNRRRQERFWYCR 571

  Fly   580 LSPNHKVIHYGDCDEKTIP----TMEELPKKLPISEIKQLLEGKECPHMKE---TRIRKSAVNLA 637
            |:.||||:||||.|:.  |    |.|.|.:|:|:::||.::.||:||||||   .:..|..:.||
Human   572 LALNHKVLHYGDLDDN--PQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKSALKQNKEVLELA 634

  Fly   638 FSITFENMEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFDTLLSMEIKLRLLDTEGV 702
            |||.::..|  ||:|:||::..:..|.||::||||:.|.|:....|.|||||||:||||||.|.:
Human   635 FSILYDPDE--TLNFIAPNKYEYCIWIDGLSALLGKDMSSELTKSDLDTLLSMEMKLRLLDLENI 697

  Fly   703 DISKDPPPIPEDPENYDFCF 722
            .|.:.|||||::|.:|||.:
Human   698 QIPEAPPPIPKEPSSYDFVY 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	DUF3361	122..275	CDD:288674	49/164 (30%)
		ELMO_CED12	296..474	CDD:282570	95/180 (53%)
		PH_ELMO1_CED-12	546..673	CDD:270166	62/133 (47%)
ELMO2	NP_573403.1	DUF3361	116..271	CDD:403139	48/159 (30%)
		ELMO_CED12	295..474	CDD:398415	99/187 (53%)
		PH_ELMO1_CED-12	539..668	CDD:270166	62/133 (47%)
		SH3-binding	700..707		3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	206	1.000	Domainoid score	I2908
eggNOG	1	0.900	-	-		E1_KOG2999
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	622	1.000	Inparanoid score	I876
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52862
OrthoDB	1	1.010	-	-		D177102at33208
OrthoFinder	1	1.000	-	-		FOG0001427
OrthoInspector	1	1.000	-	-		otm41511
orthoMCL	1	0.900	-	-		OOG6_102058
Panther	1	1.100	-	-	LDO	PTHR12771
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1314
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840