DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ced-12 and elmo3

DIOPT Version :9

Sequence 1:	NP_609548.1	Gene:	Ced-12 / 34633	FlyBaseID:	FBgn0032409	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_017209693.1	Gene:	elmo3 / 553310	ZFINID:	ZDB-GENE-050309-39	Length:	724	Species:	Danio rerio

Alignment Length:	737	Identity:	312/737 - (42%)
Similarity:	452/737 - (61%)	Gaps:	45/737 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KDSHIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNR 73
            ||  |||||::......|||.|||:.||.|.|:|:|:.|::...:||||| |....:.|:||.||
Zfish     5 KD--IVKIAIQMPGAYPQLIQLDQKKPLTSVIKEVCDKWNLPGPENYALQ-YADGIQTYITESNR 66

  Fly    74 NEIKNGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIK 138
            .:|||||:|:|..:|.:.|.|..:.:.:.....:...|..|..:|||.|||.|||...|...|:|
Zfish    67 LDIKNGSILRLTKAPGRCAEDLYKGIQSSDSNVRCDSLNLLAIVSTDITFAQEFISRDGHSLLVK 131

  Fly   139 MIEDGGQTNEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYPTNCGESALSNLE 203
            ::|| .|.:..|:.::|.:|:|||:||.||||...:.|:.:....| |.:...|:..:.:|:.||
Zfish   132 IVED-AQESPVIMTHTLTAFMELMDHGIVSWENLSSVFIKKMASFV-NAKVLDTSIQQVSLAILE 194

  Fly   204 NIVMCSNK-HVLVAEDIKLQDILRLLQ-----DVNSPVMRQ---NAIALLNALFVKADEGRRRTI 259
            ::|:.|:. ...|.::|.|:.:|..||     .:::...:|   .|:|||.||.....|..|:.:
Zfish   195 SMVLSSSSLFTEVKQEITLERLLSHLQVYVDYTIHTRTNQQLQTKAMALLMALLQAGGEADRQEL 259

  Fly   260 AQTISAKQFRLALIGN------GLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQDAHEKIKEL 318
            .:.:..:..|..:..|      .:|.||.|.||||||:.|..||.||:..:::..|:..|.:..|
Zfish   260 FEFLEKRNLRQYIHKNIIHSSSSVGDEMAHYLYVLQTVRLNHLEPRMKTPLDSYSQEQREMLHGL 324

  Fly   319 RRIAFDDNTNALNQNDDHIRRGGGSGAGNVN----FSQYYKKLGFKCDINPAQDFIETPPGILAL 379
            |:.||:..:.              ||..|..    .::.:|||||..:.||.||....|||:|||
Zfish   325 RQAAFETESE--------------SGLSNERRRSLCAKEFKKLGFSNNSNPGQDLSRCPPGLLAL 375

  Fly   380 DCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSGDFQPMFF 444
            |.|.|||..|...|::.|.|||.|.|:|||||.|:||:|..:||:||||||||:|...|:.|:||
Zfish   376 DTMAYFASRYPDAYSRFVLENSSREDKHECPFARSSIQLTLILCEILRIGEPPSETGSDYHPIFF 440

  Fly   445 THDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRNKIALLTY 509
            ..|...||.||||:..||:|||:||||.|||.....||||||.|||..:|.:|:.|:||:..|.|
Zfish   441 AQDRLLEELFCICIQLLNKTWKEMRATQEDFDKVMQVVREQITRTLASKPTSLELFKNKVNALNY 505

  Fly   510 QQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLRGTRTKDK 574
            .:|..|||.||..:||  :.|..:::|||::.|::||||:||||:.|..||.|.| :...|.:||
Zfish   506 SEILKLRQTERLHQEE--TLAPPVLELKERLKPELLELIRQQRLNRLCHGTLFRK-MSSRRRQDK 567

  Fly   575 FWYARLSPNHKVIHYGDCDEKT-IPTMEELPKKLPISEIKQLLEGKECPHMKETRIR--KSAVNL 636
            .||.||||||||:||||.:|:| :|::|.|..|:|:::||.::.||:||||||.:.:  |..::|
Zfish   568 LWYCRLSPNHKVLHYGDVEEETEMPSIEALQDKIPVADIKNVVTGKDCPHMKENKGKQTKEVLDL 632

  Fly   637 AFSITFENMEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFDTLLSMEIKLRLLDTEG 701
            |||||::..|:| |:|:|...:.|..||||::.|||:.|.|:....:.:.||||||||||||.|.
Zfish   633 AFSITYDVEEYS-LNFIASSRTDFCLWTDGLSVLLGKEMSSESMRSELEILLSMEIKLRLLDLEN 696

  Fly   702 VDISKDPPPIPEDPENYDFCFE 723
            |.|....||||:.|.|::||::
Zfish   697 VPIPDAAPPIPKPPSNFNFCYD 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	DUF3361	122..275	CDD:288674	49/161 (30%)
		ELMO_CED12	296..474	CDD:282570	81/181 (45%)
		PH_ELMO1_CED-12	546..673	CDD:270166	65/129 (50%)
elmo3	XP_017209693.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2920
eggNOG	1	0.900	-	-		E1_KOG2999
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	592	1.000	Inparanoid score	I940
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177102at33208
OrthoFinder	1	1.000	-	-		FOG0001427
OrthoInspector	1	1.000	-	-		otm24671
orthoMCL	1	0.900	-	-		OOG6_102058
Panther	1	1.100	-	-	O	PTHR12771
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1314
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.830