DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ced-12 and elmo2

DIOPT Version :9

Sequence 1:	NP_609548.1	Gene:	Ced-12 / 34633	FlyBaseID:	FBgn0032409	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_012827130.1	Gene:	elmo2 / 493485	XenbaseID:	XB-GENE-986985	Length:	732	Species:	Xenopus tropicalis

Alignment Length:	743	Identity:	327/743 - (44%)
Similarity:	481/743 - (64%)	Gaps:	53/743 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNEIK 77
            |:|:|:|.....||||.:||:.||||.|:|:|:|:|:.:.:.||.::.:.| :.|:||:.|.::|
Frog     7 IIKVAIEWPGANAQLIEIDQKRPLASIIKEVCDGFSLPNPEYYAFRYADGT-QLYITEQTRGDMK 70

  Fly    78 NGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMIED 142
            ||::|:|..|||:.|...:|.:...|...:...:|||..||.|.|||.|||..:|:..|.:::|.
Frog    71 NGTILRLAVSPSRAARQILERIQGHSTDGRLEAMKELAKLSADTTFATEFINMEGVTVLTRLVEG 135

  Fly   143 GGQT---NEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYPT---NCGESALSN 201
            |.:.   ..::|.::|.:|:|||:||.|||::...:|:.:    :..|...|:   :..:.:|:.
Frog   136 GTKLLSHYSEMLAFTLTAFLELMDHGIVSWDIVSLTFIKQ----IAGFVSQPSVDVSILQRSLAI 196

  Fly   202 LENIVMCSNKHVL---VAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRRR------ 257
            ||::|:  |...|   :|::|.:..::..|| |::..::..||||:||||:||.|.:|:
Frog   197 LESMVL--NSQALYHKIADEITVGQLICHLQ-VSNQEIQTYAIALINALFLKAPEDKRQEKPPNL 258

  Fly   258 ------TIAQTISAKQFRLALI-----GN-GLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQD 310
                  .:|.....|..|..::     || .:.|||.|||||||.||..|||:||..||::.||.
Frog   259 MDVPVSEMANAFVQKHLRSIILNHVIRGNRPIKTEMAHQLYVLQVLTFNLLEERMMTKMDSNDQA 323

  Fly   311 AHEKIKELRRIAFDDNTNALNQNDDHIRRGGGSGAGNVNFSQYYKKLGFKCDINPAQDFIETPPG 375
            ..:.|.||||||||..::|...:      |||:......:|:.||.|||...:|||.||::||||
Frog   324 QRDCIFELRRIAFDAESDASGVS------GGGTEKRKAMYSKDYKMLGFSNHVNPAMDFLQTPPG 382

  Fly   376 ILALDCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSGDFQ 440
            :||||.|:|.|:::...|.:||.|||.|.|:|||||||::|||.|:|||||::||.|.|...|:.
Frog   383 MLALDNMLYLAKHHQDTYVRIVLENSSREDKHECPFGRSAIELTKMLCDILQVGELPNEGRNDYH 447

  Fly   441 PMFFTHDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRNKIA 505
            ||||||:..||||||||:..||:|||:||||||||:....||||||.|.|..:|.:|:..:||:.
Frog   448 PMFFTHERSFEEFFCICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALASKPNSLEQLKNKLR 512

  Fly   506 LLTYQQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLRGTR 570
            .|:|.:|..|||.||.|::  |..:..||:|:|||.|:||||||||||:.|.||:.|.| ....|
Frog   513 SLSYTEILRLRQSERLSQD--DFQSKPIVELREKIQPEILELIKQQRLNRLCEGSSFRK-TGNRR 574

  Fly   571 TKDKFWYARLSPNHKVIHYGDCDEKT---IPTMEELPKKLPISEIKQLLEGKECPHMKE---TRI 629
            .:::||:.||:.||||:||||.::..   :| .|.|.:|:|:|:||.::.||:||||||   .:.
Frog   575 RQERFWFCRLALNHKVLHYGDLEDNVQGEVP-YESLQEKIPVSDIKAVVTGKDCPHMKEKSALKQ 638

  Fly   630 RKSAVNLAFSITFENMEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFDTLLSMEIKL 694
            .|..:.|||||.::..|  ||:|:||::..:..|.||:|||||:.|.|:....|.|||||||:||
Frog   639 NKEVLELAFSILYDPDE--TLNFIAPNKYEYCIWIDGVNALLGREMSSELARSDMDTLLSMEMKL 701

  Fly   695 RLLDTEGVDISKDPPPIPEDPENYDFCF 722
            ||||.|.:.|.:.|||||::|.:|||.:
Frog   702 RLLDLENIQIPEVPPPIPKEPSSYDFVY 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	DUF3361	122..275	CDD:288674	50/178 (28%)
		ELMO_CED12	296..474	CDD:282570	96/177 (54%)
		PH_ELMO1_CED-12	546..673	CDD:270166	61/132 (46%)
elmo2	XP_012827130.1	DUF3361	116..283	CDD:403139	49/173 (28%)
		ELMO_CED12	307..486	CDD:398415	100/184 (54%)
		PH_ELMO1_CED-12	551..680	CDD:270166	61/132 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2820
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	612	1.000	Inparanoid score	I898
OMA	1	1.010	-	-		QHG52862
OrthoDB	1	1.010	-	-		D177102at33208
OrthoFinder	1	1.000	-	-		FOG0001427
OrthoInspector	1	1.000	-	-		otm48724
Panther	1	1.100	-	-	LDO	PTHR12771
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1314
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080