DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ced-12 and CG10068

DIOPT Version :9

Sequence 1:	NP_609548.1	Gene:	Ced-12 / 34633	FlyBaseID:	FBgn0032409	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_649695.1	Gene:	CG10068 / 40852	FlyBaseID:	FBgn0037473	Length:	316	Species:	Drosophila melanogaster

Alignment Length:	350	Identity:	70/350 - (20%)
Similarity:	118/350 - (33%)	Gaps:	113/350 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 YPTNCGESALSNLENIVMCSNKHVLVAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEG 254
            |....|.|..|.:|..:..|          |...|.||:.|::     :.|..:.||..:.....
  Fly    37 YGAKAGASRTSQVERSLTLS----------KRPQIRRLVLDLD-----EAAPYVSNAELLDFAPR 86

  Fly   255 RRRTIAQTISAKQFR-------LALIGNGLGT-----EMTHQLYVLQTLTLGLLEKRMRMKMNAQ 307
            ..|.:.|   ||:.:       ..|.|..:.:     .:.||           :|:....|.::.
  Fly    87 AARIVMQ---AKRIKNNVHPDFARLFGTCVTSIWGYRRLMHQ-----------VEQLRAEKYDSD 137

  Fly   308 DQDAHEKIKELRRIAFDDNTNALNQNDDHIRRGGGSGAGNVNFSQYYKKLGFKCDINPAQDFIET 372
            :.|..:|:..|.::...|...                .|.|  ::.::.:||:.| :|..||  .
  Fly   138 NLDHEQKLLRLWQLLMPDTPL----------------TGRV--TKQWQDIGFQGD-DPKTDF--R 181

  Fly   373 PPGILALDCMVYFARNYTQQYAKIVRENSCRADEHECPFGRT----SIELVKVLCDILRIGEPPA 433
            ..|:|.|:.::|||..|... ||.|..:|...     ..|.|    .|.|..:..::::.|....
  Fly   182 GMGMLGLENLLYFATAYNDA-AKHVLLHSMHP-----TLGYTYAIVGINLTSMAFNLVKTGAAKT 240

  Fly   434 EQSGDFQPMFFTHDSPF---EEF---FCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKG 492
            .    |..:...|...|   |:|   :|......:|.|                        ::.
  Fly   241 H----FYNLVVQHRQDFSTVEDFHKLYCYLFFEFDRFW------------------------MES 277

  Fly   493 RPENLDDFRNKIALLTYQ--QITTL 515
            .|.|:.|||.     .||  :||.|
  Fly   278 DPRNIMDFRE-----IYQSFEITKL 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	DUF3361	122..275	CDD:288674	19/91 (21%)
		ELMO_CED12	296..474	CDD:282570	38/187 (20%)
		PH_ELMO1_CED-12	546..673	CDD:270166
CG10068	NP_649695.1	ELMO_CED12	126..284	CDD:282570	40/212 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12771
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010