DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ced-12 and Elmo2

DIOPT Version :9

Sequence 1:	NP_609548.1	Gene:	Ced-12 / 34633	FlyBaseID:	FBgn0032409	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001128427.1	Gene:	Elmo2 / 362271	RGDID:	1305784	Length:	732	Species:	Rattus norvegicus

Alignment Length:	747	Identity:	331/747 - (44%)
Similarity:	477/747 - (63%)	Gaps:	57/747 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SHIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNE 75
            |.|||:|:|.....|||:.:||:.||||.|:|:|:|||:.:.:.|.|: |....:.||||:.|::
  Rat     5 SDIVKVAIEWPGANAQLLEIDQKRPLASVIKEVCDGWSLPNPEYYTLR-YADGPQLYVTEQTRSD 68

  Fly    76 IKNGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMI 140
            ||||::|||..|||:.|...||...:.|.:.:...:|||..||.|.|||.|||...|:..|.:::
  Rat    69 IKNGTILQLAISPSRAARQLMERTQSSSMETRLDAMKELAKLSADVTFATEFINMDGIVVLTRLV 133

  Fly   141 EDGGQT---NEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYP---TNCGESAL 199
            |.|.:.   ..::|.::|.:|:|||:||.|||::...:|:.:    :..:...|   .:..:.:|
  Rat   134 ESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDLVSITFIKQ----IAGYVSQPMADVSVLQRSL 194

  Fly   200 SNLENIVMCSNK-HVLVAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRRR------ 257
            :.||::|:.|.. :..:||:|.:..::..|| |::..::..||||:||||:||.|.:|:
  Rat   195 AILESMVLNSQSLYQKIAEEITVGQLISHLQ-VSNQEIQTYAIALINALFLKAPEDKRQDKHLNP 258

  Fly   258 ------TIAQTISAKQFRLALI-----GN-GLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQD 310
                  .:|...:.|..|..::     || .:.|||.|||||||.||..|||:||..||:..||.
  Rat   259 LDLPATDMANAFAQKHLRSIILNHVIRGNRPIKTEMAHQLYVLQVLTFNLLEERMMTKMDPNDQA 323

  Fly   311 AHEKIKELRRIAFD---DNTNALNQNDDHIRRGGGSGAGNVNFSQYYKKLGFKCDINPAQDFIET 372
            ..:.|.||||||||   |.:||         .|.|:......:::.||.|||...||||.||.:|
  Rat   324 QRDIIFELRRIAFDAESDPSNA---------PGSGTEKRKAMYTKDYKMLGFTNHINPALDFTQT 379

  Fly   373 PPGILALDCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSG 437
            |||:||||.|:|.|:.:...|.:||.|||.|.|:|||||||::|||.|:||:||::||.|.|...
  Rat   380 PPGMLALDNMLYLAKVHQDTYIRIVLENSSREDKHECPFGRSAIELTKMLCEILQVGELPNEGRN 444

  Fly   438 DFQPMFFTHDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRN 502
            |:.|||||||..|||.|.||:..||:|||:||||||||:....||||||.|.|..:|.:||.|::
  Rat   445 DYHPMFFTHDRAFEELFGICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPNSLDQFKS 509

  Fly   503 KIALLTYQQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLR 567
            |:..|:|.:|..|||.||.|::  |..:..||:|:|||.|:||||||||||:.|.||:.|.| :.
  Rat   510 KLRSLSYSEILRLRQSERMSQD--DFQSPPIVELREKIQPEILELIKQQRLNRLCEGSSFRK-IG 571

  Fly   568 GTRTKDKFWYARLSPNHKVIHYGDCDEKTIP----TMEELPKKLPISEIKQLLEGKECPHMKE-- 626
            ..|.:::||:.||:.||||:||||.|:.  |    |.|.|.:|:|:::||.::.||:||||||
  Rat   572 NRRRQERFWHCRLALNHKVLHYGDLDDN--PQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKS 634

  Fly   627 -TRIRKSAVNLAFSITFENMEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFDTLLSM 690
             .:..|..:.|||||.::..|  ||:|:||::..:..|.||::||||:.|.|:....|.||||||
  Rat   635 ALKQNKEVLELAFSILYDPDE--TLNFIAPNKYEYCIWIDGLSALLGKDMSSELTKSDLDTLLSM 697

  Fly   691 EIKLRLLDTEGVDISKDPPPIPEDPENYDFCF 722
            |:||||||.|.:.|.:.|||:|::|.:|||.:
  Rat   698 EMKLRLLDLENIQIPEAPPPVPKEPSSYDFVY 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	DUF3361	122..275	CDD:288674	49/176 (28%)
		ELMO_CED12	296..474	CDD:282570	95/180 (53%)
		PH_ELMO1_CED-12	546..673	CDD:270166	61/133 (46%)
Elmo2	NP_001128427.1	DUF3361	115..283	CDD:288674	49/172 (28%)
		ELMO_CED12	309..481	CDD:282570	95/180 (53%)
		PH_ELMO1_CED-12	551..680	CDD:270166	61/133 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	206	1.000	Domainoid score	I2804
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	615	1.000	Inparanoid score	I864
OMA	1	1.010	-	-		QHG52862
OrthoDB	1	1.010	-	-		D177102at33208
OrthoFinder	1	1.000	-	-		FOG0001427
OrthoInspector	1	1.000	-	-		otm45630
orthoMCL	1	0.900	-	-		OOG6_102058
Panther	1	1.100	-	-	LDO	PTHR12771
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1314
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980