Protein Alignment Ced-12 and Elmo1

DIOPT Version :10

• Sequence 1: NP_609548.1
• Gene: Ced-12 / 34633
• FlyBaseID: FBgn0032409
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: XP_063132679.1
• Gene: Elmo1 / 361251
• RGDID: 1308182
• Length: 742
• Species: Rattus norvegicus
• Alignment Length: 757
• Identity: 345/757 - (45%)
• Similarity: 483/757 - (63%)
• Gaps: 65/757 - (8%)

  Fly    11 SHIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNE 75
            |.|||:|:|......:|:.:||:.||::.|:|:|:|||:::|:.:|||..:.:| .|:|||||||
  Rat     5 SDIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSN-FYITEKNRNE 68

  Fly    76 IKNGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMI 140
            ||||::|:|..||::.|....|.:.:.|...|...||:|.|||.|.|||.|||...|:..|.:|:
  Rat    69 IKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEFINLDGISLLTQMV 133

  Fly   141 EDGGQTNE-----------DILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYPTNC 194
            |.|.:..:           |:|.::|.:|||||:||.|||:....:|:.:....| |......:.
  Rat   134 ESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFV-NKSAIDISI 197

  Fly   195 GESALSNLENIVMCSNKHVL---VAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRR 256
            .:.:|:.||::|:  |.|.|   ||::|.:..::..||..:..: :...||::||||:||.:.||
  Rat   198 LQRSLAILESMVL--NSHDLYQKVAQEITIGQLIPHLQGTDQEI-QTYTIAVINALFLKAPDERR 259

  Fly   257 RT---------------IAQTISAKQFRLALIGN------GLGTEMTHQLYVLQTLTLGLLEKRM 300
            :.               :|..::.||.|..::.:      .:..||.|||||||.||..|||.||
  Rat   260 QVDVESNVDILDCPLTEMANILAQKQLRYIILTHVIRAQRAINNEMAHQLYVLQVLTFNLLEDRM 324

  Fly   301 RMKMNAQDQDAHEKIKELRRIAFDDNTNALNQNDDHIRRGGGSGAGNVNFSQY---YKKLGFKCD 362
            ..||:.|||...:.|.||||||||..:...|          .||:.....|.|   ||||||...
  Rat   325 MTKMDPQDQAQRDIIFELRRIAFDAESEPNN----------SSGSMEKRKSMYTRDYKKLGFINH 379

  Fly   363 INPAQDFIETPPGILALDCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILR 427
            :|||.||.:||||:||||.|:|||:::...|.:||.|||.|.|:|||||||:||||.|:||:||:
  Rat   380 VNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILK 444

  Fly   428 IGEPPAEQSGDFQPMFFTHDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKG 492
            :||.|:|...||.|||||||..||||||||:..||:|||:||||:|||:....||:||:.|.|..
  Rat   445 VGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTT 509

  Fly   493 RPENLDDFRNKIALLTYQQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLV 557
            :|.:||.|::|:..|:|.:|..:||.||.::|  |..:..|::|||||.|:||||||||||:.||
  Rat   510 KPSSLDQFKSKLQNLSYTEILKIRQSERMNQE--DFQSRPILELKEKIQPEILELIKQQRLNRLV 572

  Fly   558 EGTHFAKYLRGTRTKDKFWYARLSPNHKVIHYGDCDEK---TIPTMEELPKKLPISEIKQLLEGK 619
            |||.|.| |...|.:|||||.||||||||:||||.:|.   .:| .:.|..|||:::||.::.||
  Rat   573 EGTCFRK-LNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVP-HDSLQDKLPVADIKAVVTGK 635

  Fly   620 ECPHMKE---TRIRKSAVNLAFSITFENMEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKN 681
            :||||||   .:..|..:.|||||.:::  :..|:|:|||:..:..||||:|||||:.|:|....
  Rat   636 DCPHMKEKGALKQNKEVLELAFSILYDS--NCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTR 698

  Fly   682 EDFDTLLSMEIKLRLLDTEGVDISKDPPPIPEDPENYDFCFE 723
            .|.||||||||||||||.|.:.|...|||||::|.||||.::
  Rat   699 NDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNYDFVYD 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	ELMO_ARM	122..277	CDD:463369	53/189 (28%)
		ELMO_CED12	295..477	CDD:461411	104/184 (57%)
		PH_ELMO1_CED-12	546..673	CDD:270166	69/132 (52%)
Elmo1	XP_063132679.1	None