DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ced-12 and Elmo3

DIOPT Version :9

Sequence 1:	NP_609548.1	Gene:	Ced-12 / 34633	FlyBaseID:	FBgn0032409	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_030099358.1	Gene:	Elmo3 / 234683	MGIID:	2679007	Length:	747	Species:	Mus musculus

Alignment Length:	753	Identity:	311/753 - (41%)
Similarity:	442/753 - (58%)	Gaps:	58/753 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 HIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNEI 76
            ::|||||:..|.|.|||.|||..|||:.::|:|:.||::..::|||||.: .:|||:||.||.||
Mouse     6 NVVKIAVQMSDAIPQLIQLDQAKPLATVLKEVCDAWSLTHPEHYALQFAD-GHRKYITENNRLEI 69

  Fly    77 KNGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMIE 141
            ||||:|.|..:|...|...:..|.|.|.:.....|:.|..|::|.|||.|.|...||..|..:||
Mouse    70 KNGSILCLSTAPDLKAQQLLGRLQNTSREGCCEVLRNLVLLASDMTFAQEVISRDGLQKLSTIIE 134

  Fly   142 DGGQTNEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYPTNCGESALSNLENIV 206
            :|....| :|...|.:|:||||||.||||....|||.:.|..| |......:....||..||::.
Mouse   135 NGDDLGE-MLALGLRAFLELMEHGVVSWETLSISFVRKVISYV-NMNLMDASVQPLALRLLESVT 197

  Fly   207 MCSNK-HVLVAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRRRTIAQTISAKQFRL 270
            :.|.. ..||..::.|..:|..||.:|.. ::..|:|||.||...|....|:.:...:..|..|.
Mouse   198 LSSPALGQLVKSEVPLDRLLVHLQVMNHQ-LQTKAMALLTALLQGASPTERKEMLDHLWKKNLRQ 261

  Fly   271 ALIGNG---------------------------------LGTEMTHQLYVLQTLTLGLLEKRMRM 302
            .:...|                                 :|.||.|.|||||.|||||||.|||.
Mouse   262 FIYKVGWTRPRRPSPQSSFPWESHPSLVVFQNIIHSATPMGDEMAHHLYVLQALTLGLLEPRMRT 326

  Fly   303 KMNAQDQDAHEKIKELRRIAFDDNTNALNQNDDHIRRGGGSGAGNVN--FSQYYKKLGFKCDINP 365
            .::...|:..::::.||:.||:....:|         |.|..|....  ..:.::||||. :.||
Mouse   327 PLDPYSQEQRDQLQALRQAAFEPEGESL---------GTGLSADRRRSLCVREFRKLGFS-NSNP 381

  Fly   366 AQDFIETPPGILALDCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGE 430
            |||....|||:||||.|:||:|:....|::.|.|||.|.|:|||||.|:||:|..:||::||:||
Mouse   382 AQDLERVPPGLLALDNMLYFSRHAPSAYSRFVLENSSREDKHECPFARSSIQLTALLCELLRVGE 446

  Fly   431 PPAEQSGDFQPMFFTHDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPE 495
            |.:|.:.||.||||:.|..|.|.||:.:..||:|||:||||.|||.....|||||:.|||..:|.
Mouse   447 PCSETAQDFSPMFFSQDHSFHELFCVAIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPT 511

  Fly   496 NLDDFRNKIALLTYQQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGT 560
            :|:.||.|:..|||.::..|||.||..:|  .:.|..|::|:||:.|:::.||:||||..|.||.
Mouse   512 SLELFRTKVNALTYGEVLRLRQTERLHQE--GTLAPPILELREKLKPELMGLIRQQRLLRLCEGM 574

  Fly   561 HFAKYLRGTRTKDKFWYARLSPNHKVIHYGDCDE-KTIPTMEELPKKLPISEIKQLLEGKECPHM 624
            .|.| :...|.:||.|:..|||||||:.|||.:| ...||:|.||::||:::|:.||.||:|||:
Mouse   575 LFRK-ISSRRRQDKLWFCCLSPNHKVLQYGDVEEGAKPPTLESLPEQLPVADIRALLMGKDCPHV 638

  Fly   625 KET---RIRKSAVNLAFSITFEN-MEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFD 685
            :|.   :..|....|||||:::: .|.:.|:|:||.:..|..||||::||||..|.|:....|.:
Mouse   639 REKGSGKQNKDLYELAFSISYDHGEEEAYLNFIAPSKRDFYLWTDGLSALLGSTMGSELTRLDLE 703

  Fly   686 TLLSMEIKLRLLDTEGVDISKDPPPIPEDPENYDFCFE 723
            .||:||.|||||:.|.|.|.:.|||:|..|.|::||::
Mouse   704 QLLTMETKLRLLELENVPIPEQPPPVPPPPTNFNFCYD 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	DUF3361	122..275	CDD:288674	53/153 (35%)
		ELMO_CED12	296..474	CDD:282570	78/179 (44%)
		PH_ELMO1_CED-12	546..673	CDD:270166	61/131 (47%)
Elmo3	XP_030099358.1	DUF3361	115..266	CDD:371757	53/153 (35%)
		ELMO_CED12	319..490	CDD:368083	79/180 (44%)
		PH-like	561..690	CDD:388408	60/129 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	206	1.000	Domainoid score	I2902
eggNOG	1	0.900	-	-		E1_KOG2999
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	624	1.000	Inparanoid score	I870
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177102at33208
OrthoFinder	1	1.000	-	-		FOG0001427
OrthoInspector	1	1.000	-	-		otm43562
orthoMCL	1	0.900	-	-		OOG6_102058
Panther	1	1.100	-	-	O	PTHR12771
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1314
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830