DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ced-12 and C56G7.3

DIOPT Version :9

Sequence 1:	NP_609548.1	Gene:	Ced-12 / 34633	FlyBaseID:	FBgn0032409	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_497699.1	Gene:	C56G7.3 / 175439	WormBaseID:	WBGene00008348	Length:	322	Species:	Caenorhabditis elegans

Alignment Length:	311	Identity:	66/311 - (21%)
Similarity:	110/311 - (35%)	Gaps:	90/311 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 VLVAEDIKLQDILRLL---------------QDVNSP---VMRQNAIALLNALFVKADEGRRRTI 259
            |.||.:..|||:..||               .||..|   |:.:.:|            ..|.|.
Worm    48 VAVAPETSLQDLYPLLIATSSSNAPPSATPTDDVTDPEVQVVSRESI------------DNRSTF 100

  Fly   260 AQTISAKQFRLALIGNGLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQDAHEKIKELRRIA-- 322
            .:.|.      ..:...:.::|..:.|..:||.|.|          ||....||.......::
Worm   101 NRIID------VCLCRPVKSQMGPKAYTDKTLILKL----------AQIPYDHENGTHWLLLSDY 149

  Fly   323 FDDNTNALNQNDD--HIRRGGGSGAGNVNFSQYYKKLGFKCDINPAQDFIETPPGILALDCMVYF 385
            |::.:.:|..:.:  |:......||       ::..:||: ...|..||  ...|:|.|..|
Worm   150 FNNVSRSLMTSSEYSHVTNPSRVGA-------HWVTVGFQ-SATPHTDF--RGCGVLGLLQM--- 201

  Fly   386 ARNYTQQYAKIVRENSCRA-------DEHECPFGRTSIELVKVLCDILRIGEPPAEQSGD----F 439
             ..:||:    |..|..||       :.::.|....||.:..:|...|:.|  ..:..|:    .
Worm   202 -HTFTQR----VPANLLRAIVLLATTEPNDFPLAVVSINITSILLTQLKKG--ALDNFGNEIEGL 259

  Fly   440 QPMFFT-HDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRT 489
            .|.|.. |.|....|   |.|     :|..:.|..:..|.||.:..|::::
Worm   260 YPFFSALHASAMCRF---CSI-----YKSQKCTLANTQTIFSEITRQLEKS 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	DUF3361	122..275	CDD:288674	16/79 (20%)
		ELMO_CED12	296..474	CDD:282570	40/193 (21%)
		PH_ELMO1_CED-12	546..673	CDD:270166
C56G7.3	NP_497699.1	ELMO_CED12	127..284	CDD:282570	41/194 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910