Protein Alignment Ced-12 and ced-12

DIOPT Version :9

• Sequence 1: NP_609548.1
• Gene: Ced-12 / 34633
• FlyBaseID: FBgn0032409
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_001293276.1
• Gene: ced-12 / 172890
• WormBaseID: WBGene00000426
• Length: 738
• Species: Caenorhabditis elegans
• Alignment Length: 787
• Identity: 162/787 - (20%)
• Similarity: 325/787 - (41%)
• Gaps: 142/787 - (18%)

  Fly     3 PKKTTVKDSHIVK--IAVERE----DHIAQL-----------IN-LDQRHPLASKIQEICNGWSI 49
            |..|::.: |:||  :.:::|    :|.|.:           || |:|:  |...::......::
 Worm    19 PVDTSLPE-HVVKGAVVIDKEFTIWNHRAVIPSNALHTVFITINLLEQK--LTDVVKMAARSMNL 80

  Fly    50 SDHQNYALQFYEPTNRKYVTEKNRNEIKNGSVLQLQYSPSKTACDAMEVLLNG---SPQEKALRL 111
            |:..:|.|...:|  ::::|:.|.|.:.:|.:|.|..||........|:|..|   |..|.|  :
 Worm    81 SEDDSYGLMADKP--KRFITDDNLNSLGSGFILTLCASPDHYVKRITEILTEGNNISQMENA--V 141

  Fly   112 KELTSLSTDHTFALEFIKEKGLDTLIKMIEDG----GQTNEDILKYSLASFVELMEHGTVSWE-V 171
            |.|...|.|......|.:...|:.|..:|.|.    ..|.......:|:|.:||.. |..:|: |
 Worm   142 KTLDEFSLDPALIEAFYRCSSLELLFSLIRDDRVCMSSTLLSTCLRALSSMLELAV-GDFTWKSV 205

  Fly   172 PENSFVARNIEIVRNFQKYPTNCGESALSNLENIVMCSN-KHVLVAEDIKLQDILRLLQDVNSPV 235
            |.:..|:....:....::...|...:||..||.:|:..: ....:.|::.::.::|.::..:..:
 Worm   206 PNDVVVSMASLVTGKAKREEANTLLAALQMLEQLVIGDDTTRDWILEEVPIETLIRHVEKSDERI 270

  Fly   236 MRQNAIALLNALFVKA-DEGRRRTIAQTISAKQFRLA----LIGNGLGT---EMTHQLYVLQTLT 292
             ...|::|:|::..:. |:.:|..:.:::....||.|    |:..|.|.   ....||..:|...
 Worm   271 -ALCALSLMNSMIRRCPDDEKRFELIKSLEVVPFRNAVHSSLLRGGGGVRNLNAIEQLVEVQRSL 334

  Fly   293 LGLLEKRMRMKMNAQ-------DQDAHEKIKELRRIAFDDNTNALNQNDDHIRRGGGSGAGNVNF 350
            :...|.........|       .:|..|:|:|:.:          :|..:|
 Worm   335 ISAYETSPPTDAEVQKILDIESSEDVSEEIREMWK----------SQIGEH-------------- 375

  Fly   351 SQYYKKLGFKCDINPAQDFIETPPGILALDCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTS 415
                     :|             |.||...||.||....|....::.||:.|.:..:.......
 Worm   376 ---------RC-------------GRLAAISMVQFAEKSPQDLRMLISENTMRIEGGKWQLIPMW 418

  Fly   416 IELVKVLCDILRIGEPPAEQSGDFQPMFFTHDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFS 480
            :....:..::.|: .|..::......:.|:.::||...|...|...:|||::|:|...:......
 Worm   419 MRCCDIAAELFRV-IPGRDELDRLIVVLFSTETPFPAVFACIVHLFHRTWREMQAKGGEMEKVAC 482

  Fly   481 VVREQIQRTLKGRP-ENLDDFRNKIALLTYQQITTLRQQERTSKEECDSTASAIVKLKEKISPQI 544
            ||.||::..||.|. :::::....:...:|:.:..:.::|:..||.....:.|:::||.|:.|::
 Worm   483 VVLEQLRHVLKRREIQDVEELSADLETFSYRAMQEIWREEQLGKENIQLHSEAVIQLKSKLRPKM 547

  Fly   545 LELIKQQRLSFLVEGTHFAKYLRG-TRTKDKFWYARLSPNHKVIHYGDCDEKT------------ 596
            .||::...|::|..|..|.|..:. :..|..||:.:|..:.|::....||.:.
 Worm   548 EELVRINHLNYLKLGAVFRKPQKSKSLAKLAFWHWKLDASEKMLTITGCDGENYVEGVQRDDIRQ 612

  Fly   597 --------IPTMEELPKKLPISEI-----KQLLEGKECPHMKETRIRKSAVNLAFSITFENMEHS 648
                    :...:|:.:|...|..     .|:|.|               :.:....|.:..|..
 Worm   613 VWIKDIADVTNNDEIDRKASSSRFTSSPSTQMLRG---------------IRVQLKTTNDMKEGE 662

  Fly   649 TLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFDTLLSMEIKLRLLDTEGVDISKDP--PPI 711
            .|..:..||:....|.:|:..|:|...|..:.:...:.:|.||:::|||:.:..:..:.|  |||
 Worm   663 VLMALTSDETQSVIWLEGLAELIGSKAVKSETDAMVERMLKMELRVRLLNVKLTNPEEKPEIPPI 727

  Fly   712 PEDPENY 718
            |:|.:::
 Worm   728 PDDIKSF 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	DUF3361	122..275	CDD:288674	32/163 (20%)
		ELMO_CED12	296..474	CDD:282570	32/184 (17%)
		PH_ELMO1_CED-12	546..673	CDD:270166	28/152 (18%)
ced-12	NP_001293276.1	DUF3361	163..311	CDD:371757	30/149 (20%)
		ELMO_CED12	<377..472	CDD:368083	23/108 (21%)
		PH_12	551..686	CDD:374554	26/149 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2999
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56685
Inparanoid	1	1.050	128	1.000	Inparanoid score	I3234
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52862
OrthoDB	1	1.010	-	-		D177102at33208
OrthoFinder	1	1.000	-	-		FOG0001427
OrthoInspector	1	1.000	-	-		oto18735
orthoMCL	1	0.900	-	-		OOG6_102058
Panther	1	1.100	-	-	LDO	PTHR12771
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2448
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910