Protein Alignment Ced-12 and Elmo2

DIOPT Version :10

• Sequence 1: NP_609548.1
• Gene: Ced-12 / 34633
• FlyBaseID: FBgn0032409
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_997589.1
• Gene: Elmo2 / 140579
• MGIID: 2153045
• Length: 732
• Species: Mus musculus
• Alignment Length: 744
• Identity: 330/744 - (44%)
• Similarity: 476/744 - (63%)
• Gaps: 51/744 - (6%)

  Fly    11 SHIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNE 75
            |.|||:|:|.....|||:.:||:.||||.|:|:|:|||:.:.:.|.|: |....:.||||:.||:
Mouse     5 SDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLPNPEYYTLR-YADGPQLYVTEQTRND 68

  Fly    76 IKNGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMI 140
            ||||::|||..|||:.|...||...:.|.:.:...:|||..||.|.|||.|||...|:..|.:::
Mouse    69 IKNGTILQLAVSPSRAARQLMERTQSSSMETRLDAMKELAKLSADVTFATEFINMDGIIVLTRLV 133

  Fly   141 EDGGQT---NEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYP---TNCGESAL 199
            |.|.:.   ..::|.::|.:|:|||:||.|||::...:|:.:    :..:...|   .:..:.:|
Mouse   134 ESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDMVSVTFIKQ----IAGYVSQPMVDVSILQRSL 194

  Fly   200 SNLENIVMCSNK-HVLVAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRRR------ 257
            :.||::|:.|.. :..:||:|.:..::..|| |::..::..||||:||||:||.|.:|:
Mouse   195 AILESMVLNSQSLYQKIAEEITVGQLISHLQ-VSNQEIQTYAIALINALFLKAPEDKRQDKHLNP 258

  Fly   258 ------TIAQTISAKQFRLALI-----GN-GLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQD 310
                  .:|...:.|..|..::     || .:.|||.|||||||.||..|||:||..||:..||.
Mouse   259 LDLPVTDMANAFAQKHLRSIILNHVIRGNRPIKTEMAHQLYVLQVLTFNLLEERMMTKMDPNDQA 323

  Fly   311 AHEKIKELRRIAFDDNTNALNQNDDHIRRGGGSGAGNVNFSQYYKKLGFKCDINPAQDFIETPPG 375
            ..:.|.||||||||..::..|.      .|.|:......:::.||.|||...||||.||.:||||
Mouse   324 QRDIIFELRRIAFDAESDPSNV------PGSGTEKRKAMYTKDYKMLGFTNHINPALDFTQTPPG 382

  Fly   376 ILALDCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSGDFQ 440
            :||||.|:|.|:.:...|.:||.|||.|.|:|||||||::|||.|:||:||::||.|.|...|:.
Mouse   383 MLALDNMLYLAKVHQDTYIRIVLENSSREDKHECPFGRSAIELTKMLCEILQVGELPNEGRNDYH 447

  Fly   441 PMFFTHDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRNKIA 505
            |||||||..|||.|.||:..||:|||:||||||||:....||||||.|.|..:|.:||.|::|:.
Mouse   448 PMFFTHDRAFEELFGICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPNSLDQFKSKLR 512

  Fly   506 LLTYQQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLRGTR 570
            .|:|.:|..|||.||.|::  |..:..||:|:|||.|:||||||||||:.|.||:.|.| :...|
Mouse   513 SLSYSEILRLRQSERMSQD--DFQSPPIVELREKIQPEILELIKQQRLNRLCEGSSFRK-IGNRR 574

  Fly   571 TKDKFWYARLSPNHKVIHYGDCDEKTIP----TMEELPKKLPISEIKQLLEGKECPHMKE---TR 628
            .:::||:.||:.||||:||||.|:.  |    |.|.|.:|:|:::||.::.||:||||||   .:
Mouse   575 RQERFWHCRLALNHKVLHYGDLDDN--PQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKSALK 637

  Fly   629 IRKSAVNLAFSITFENMEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFDTLLSMEIK 693
            ..|..:.|||||.::..|  ||:|:||::..:..|.||::||||:.|.|:....|.|||||||:|
Mouse   638 QNKEVLELAFSILYDPDE--TLNFIAPNKYEYCIWIDGLSALLGKDMSSELTKSDLDTLLSMEMK 700

  Fly   694 LRLLDTEGVDISKDPPPIPEDPENYDFCF 722
            |||||.|.:.|.:.|||:|::|.:|||.:
Mouse   701 LRLLDLENIQIPEAPPPVPKEPSSYDFVY 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	ELMO_ARM	122..277	CDD:463369	51/179 (28%)
		ELMO_CED12	295..477	CDD:461411	97/181 (54%)
		PH_ELMO1_CED-12	546..673	CDD:270166	61/133 (46%)
Elmo2	NP_997589.1	ELMO_ARM	115..284	CDD:463369	49/173 (28%)
		ELMO_CED12	307..486	CDD:461411	97/184 (53%)
		PH_ELMO1_CED-12	551..680	CDD:270166	61/133 (46%)
		SH3-binding	712..719		3/6 (50%)