DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ced-12 and Elmo2

DIOPT Version :9

Sequence 1:NP_609548.1 Gene:Ced-12 / 34633 FlyBaseID:FBgn0032409 Length:724 Species:Drosophila melanogaster
Sequence 2:NP_997589.1 Gene:Elmo2 / 140579 MGIID:2153045 Length:732 Species:Mus musculus


Alignment Length:744 Identity:330/744 - (44%)
Similarity:476/744 - (63%) Gaps:51/744 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 SHIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNE 75
            |.|||:|:|.....|||:.:||:.||||.|:|:|:|||:.:.:.|.|: |....:.||||:.||:
Mouse     5 SDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLPNPEYYTLR-YADGPQLYVTEQTRND 68

  Fly    76 IKNGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMI 140
            ||||::|||..|||:.|...||...:.|.:.:...:|||..||.|.|||.|||...|:..|.:::
Mouse    69 IKNGTILQLAVSPSRAARQLMERTQSSSMETRLDAMKELAKLSADVTFATEFINMDGIIVLTRLV 133

  Fly   141 EDGGQT---NEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYP---TNCGESAL 199
            |.|.:.   ..::|.::|.:|:|||:||.|||::...:|:.:    :..:...|   .:..:.:|
Mouse   134 ESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDMVSVTFIKQ----IAGYVSQPMVDVSILQRSL 194

  Fly   200 SNLENIVMCSNK-HVLVAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRRR------ 257
            :.||::|:.|.. :..:||:|.:..::..|| |::..::..||||:||||:||.|.:|:      
Mouse   195 AILESMVLNSQSLYQKIAEEITVGQLISHLQ-VSNQEIQTYAIALINALFLKAPEDKRQDKHLNP 258

  Fly   258 ------TIAQTISAKQFRLALI-----GN-GLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQD 310
                  .:|...:.|..|..::     || .:.|||.|||||||.||..|||:||..||:..||.
Mouse   259 LDLPVTDMANAFAQKHLRSIILNHVIRGNRPIKTEMAHQLYVLQVLTFNLLEERMMTKMDPNDQA 323

  Fly   311 AHEKIKELRRIAFDDNTNALNQNDDHIRRGGGSGAGNVNFSQYYKKLGFKCDINPAQDFIETPPG 375
            ..:.|.||||||||..::..|.      .|.|:......:::.||.|||...||||.||.:||||
Mouse   324 QRDIIFELRRIAFDAESDPSNV------PGSGTEKRKAMYTKDYKMLGFTNHINPALDFTQTPPG 382

  Fly   376 ILALDCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSGDFQ 440
            :||||.|:|.|:.:...|.:||.|||.|.|:|||||||::|||.|:||:||::||.|.|...|:.
Mouse   383 MLALDNMLYLAKVHQDTYIRIVLENSSREDKHECPFGRSAIELTKMLCEILQVGELPNEGRNDYH 447

  Fly   441 PMFFTHDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRNKIA 505
            |||||||..|||.|.||:..||:|||:||||||||:....||||||.|.|..:|.:||.|::|:.
Mouse   448 PMFFTHDRAFEELFGICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPNSLDQFKSKLR 512

  Fly   506 LLTYQQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLRGTR 570
            .|:|.:|..|||.||.|::  |..:..||:|:|||.|:||||||||||:.|.||:.|.| :...|
Mouse   513 SLSYSEILRLRQSERMSQD--DFQSPPIVELREKIQPEILELIKQQRLNRLCEGSSFRK-IGNRR 574

  Fly   571 TKDKFWYARLSPNHKVIHYGDCDEKTIP----TMEELPKKLPISEIKQLLEGKECPHMKE---TR 628
            .:::||:.||:.||||:||||.|:.  |    |.|.|.:|:|:::||.::.||:||||||   .:
Mouse   575 RQERFWHCRLALNHKVLHYGDLDDN--PQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKSALK 637

  Fly   629 IRKSAVNLAFSITFENMEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFDTLLSMEIK 693
            ..|..:.|||||.::..|  ||:|:||::..:..|.||::||||:.|.|:....|.|||||||:|
Mouse   638 QNKEVLELAFSILYDPDE--TLNFIAPNKYEYCIWIDGLSALLGKDMSSELTKSDLDTLLSMEMK 700

  Fly   694 LRLLDTEGVDISKDPPPIPEDPENYDFCF 722
            |||||.|.:.|.:.|||:|::|.:|||.:
Mouse   701 LRLLDLENIQIPEAPPPVPKEPSSYDFVY 729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ced-12NP_609548.1 DUF3361 122..275 CDD:288674 49/176 (28%)
ELMO_CED12 296..474 CDD:282570 93/177 (53%)
PH_ELMO1_CED-12 546..673 CDD:270166 61/133 (46%)
Elmo2NP_997589.1 DUF3361 115..283 CDD:371757 49/172 (28%)
ELMO_CED12 308..481 CDD:368083 94/178 (53%)
PH_ELMO1_CED-12 551..680 CDD:270166 61/133 (46%)
SH3-binding 712..719 3/6 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 206 1.000 Domainoid score I2902
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 624 1.000 Inparanoid score I870
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52862
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001427
OrthoInspector 1 1.000 - - otm43562
orthoMCL 1 0.900 - - OOG6_102058
Panther 1 1.100 - - LDO PTHR12771
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1314
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.970

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