DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ced-12 and elmo3

DIOPT Version :9

Sequence 1:	NP_609548.1	Gene:	Ced-12 / 34633	FlyBaseID:	FBgn0032409	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_002931693.1	Gene:	elmo3 / 100489944	XenbaseID:	XB-GENE-6045193	Length:	715	Species:	Xenopus tropicalis

Alignment Length:	743	Identity:	303/743 - (40%)
Similarity:	439/743 - (59%)	Gaps:	54/743 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIPKKTTVKDSHIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNR 65
            |.|.|      :|||||::......|||:|:|..||::.::::|:.|:|::.::|||| |...::
Frog     1 MEPPK------NIVKIAIQMMGAYPQLIDLNQSKPLSAVLKDVCDAWNINNSEHYALQ-YVDGHQ 58

  Fly    66 KYVTEKNRNEIKNGSVLQLQYSPSKTACDAMEVLLNGSPQE----KALRLKELTSLSTDHTFALE 126
            :|:||.||..|||||:|:|..||.|.|..    |.||:..:    |:..||:|..||.|.|||.|
Frog    59 EYITESNRTAIKNGSILRLTTSPDKEASS----LCNGAQSQNQDVKSESLKKLADLSRDVTFAQE 119

  Fly   127 FIKEKGLDTLIKMIEDGGQTNEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYP 191
            ||...||..|.|:||:..:..: |:.::|.:..||||||.||||....:|:.:....| |.....
Frog   120 FISRDGLTILSKIIEEEKELGK-IMAHTLRAISELMEHGFVSWETFSTTFIHKVATFV-NMNLMD 182

  Fly   192 TNCGESALSNLENIVMC-SNKHVLVAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGR 255
            :...:.:|:.||::|.. :|...||..::.|..:|.||| |.:..|:...:||..||..|..:..
Frog   183 SEITQLSLAILESVVQSDTNLGELVRREVTLDRLLVLLQ-VTNKEMQTKVMALFIALMQKVGDKE 246

  Fly   256 RRTIAQTISAKQFRLAL---IGNG---LGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQDAHEK 314
            |..:.:.:..|..|..:   |.|.   ||.||:|.|||||.|:|||||.|||..|:|.|.|..::
Frog   247 REEMLEYLWKKNMRQFIHKHIINEWSILGDEMSHYLYVLQCLSLGLLEPRMRNCMDANDADQRQQ 311

  Fly   315 IKELRRIAFDDNTNALNQNDDHIRRGGGSGAGNVN-------FSQYYKKLGFKCDINPAQDFIET 372
            ::.||..||...               |...|:::       .::.::||||....:|.||...:
Frog   312 LQSLRIAAFPQE---------------GEDGGHMSSERRRSLCAKEFRKLGFLNSGSPWQDLCFS 361

  Fly   373 PPGILALDCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSG 437
            |||:||||.||||:......|::.|.|||.|.|:|.|||.|:||.|..:||||||:|||.:|...
Frog   362 PPGLLALDNMVYFSTRCPNAYSRFVLENSSREDQHACPFARSSIHLSLMLCDILRVGEPASETGQ 426

  Fly   438 DFQPMFFTHDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRN 502
            :|..:|:..|...:|.||:|:..||:|||:||||.|||....:||:|||.||....|.:||.||.
Frog   427 NFLTLFYAQDHFLQELFCVCIQLLNKTWKEMRATQEDFDKVMNVVKEQISRTFANPPSSLDSFRG 491

  Fly   503 KIALLTYQQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLR 567
            :|..|.|.:|..|||.||.:::|.  .:..:::|::.:...:|.||||.||.:|.|||.|.| :.
Frog   492 RIFSLNYSEILKLRQAERVNQDEV--LSPPVMELRKALKTDLLSLIKQHRLHYLCEGTKFRK-IS 553

  Fly   568 GTRTKDKFWYARLSPNHKVIHYGDCDEK-TIPTMEELPKKLPISEIKQLLEGKECPHMKET-RIR 630
            ..|.:||.|:.||||||||:||||.::. ..|.:|.|.:|:.:|:||.:|.|::||||:|. :..
Frog   554 NRRRQDKLWFCRLSPNHKVLHYGDLEDNIDNPPVEMLQEKISVSDIKDVLTGRDCPHMREKGKQN 618

  Fly   631 KSAVNLAFSITFENMEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFDTLLSMEIKLR 695
            |..|..||||.::  ..|.|:|:|...|.|..|.||:|||||:.|.|:....|.|.|||.|:|||
Frog   619 KEIVERAFSICYD--VDSCLNFIAATHSEFCLWMDGLNALLGREMTSEYTRNDLDVLLSTELKLR 681

  Fly   696 LLDTEGVDISKDPPPIPEDPENYDFCFE 723
            |||.|.:.|.:.|||||..|:|||:|::
Frog   682 LLDLENIPIPEHPPPIPPRPQNYDYCYQ 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ced-12	NP_609548.1	DUF3361	122..275	CDD:288674	50/156 (32%)
		ELMO_CED12	296..474	CDD:282570	74/184 (40%)
		PH_ELMO1_CED-12	546..673	CDD:270166	61/128 (48%)
elmo3	XP_002931693.1	DUF3361	115..267	CDD:371757	49/154 (32%)
		ELMO_CED12	292..463	CDD:368083	75/185 (41%)
		PH_ELMO1_CED-12	534..659	CDD:270166	61/127 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5228
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	612	1.000	Inparanoid score	I898
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177102at33208
OrthoFinder	1	1.000	-	-		FOG0001427
OrthoInspector	1	1.000	-	-		otm48724
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1314
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060