DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mt2 and DNMT2

DIOPT Version :9

Sequence 1:	NP_001036355.1	Gene:	Mt2 / 34632	FlyBaseID:	FBgn0028707	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_568474.1	Gene:	DNMT2 / 832623	AraportID:	AT5G25480	Length:	383	Species:	Arabidopsis thaliana

Alignment Length:	397	Identity:	135/397 - (34%)
Similarity:	198/397 - (49%)	Gaps:	88/397 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FRVLELFSGIGGMHYAFNYAQLDGQIVAALDVNTVANAVYAHNYGSNLVKTR----NIQSLSVKE 63
            ::|||.:||||||.|:...:.:..::|.|.::|..||.||.||:     |.|    |||||:..:
plant    15 WQVLEFYSGIGGMRYSLMASGIVSEVVEAFEINDSANDVYQHNF-----KHRPYQGNIQSLTAAD 74

  Fly    64 VTKLQANMLLMSPPCQPHTRQGLQRDTEDKRSDALTHLCGLIPE-CQELEYILMENVKGFESSQA 127
            :.|..|:..|:||||||:||||||:.:.|.|:.:...:..|||. .:..:.:.:|||.|||:|..
plant    75 LDKYNADAWLLSPPCQPYTRQGLQKHSGDARAFSFLRILELIPHTTKPPQMLFVENVVGFETSDT 139

  Fly   128 RNQFIESLERSGFHWREFILTPTQFNVPNTRYRYYCIARKGADFPF----AGGK-IWEEMP---- 183
            ..:.|.:|.:..:..:||||:|.||.||.:|.||:|:|:: ...||    :..| :|...|
plant   140 HMEMIGTLTKLDYVTQEFILSPLQFGVPYSRPRYFCLAKR-KPLPFKSQHSNNKLLWSPDPLYGR 203

  Fly   184 ------GAIAQNQGLSQIAEIVE----------------------ENVSPD-------------- 206
                  |.....:||.::.|..:                      ||.|.|
plant   204 DDQVEFGKCQAEEGLDKLLEFCKPVEKFLELAAHVDGEPSSVDDSENGSKDCCGQEGDSVPDSVH 268

  Fly   207 -FLVPDDVLTKRVLVMDIIHPAQSRSMCFTKGYTHYTEGTGSAYTPLSEDESHRIFELVKEIDTS 270
             :|||..::.:....|||::|...|..||||.|..|.:||||..
plant   269 QYLVPVSLIERWGNAMDIVYPDSKRCCCFTKSYYRYVKGTGSLL--------------------- 312

  Fly   271 NQDASKSEKILQQRLDLLHQVRLRYFTPREVARLMSFPENFEFPPETTNRQKYRLLGNSINVKVV 335
               |:...|| :.:...|.:.|||||||||||...||||:||||...:.||:|.:||||::|.||
plant   313 ---ATVQPKI-KGKESCLKEQRLRYFTPREVANFHSFPEDFEFPKHISLRQRYAMLGNSLSVAVV 373

  Fly   336 GELIKLL 342
            ..|::.|
plant   374 APLLRYL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mt2	NP_001036355.1	AdoMet_MTases	3..342	CDD:302624	134/395 (34%)
DNMT2	NP_568474.1	Cyt_C5_DNA_methylase	15..381	CDD:238192	135/397 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I906
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3249
Inparanoid	1	1.050	197	1.000	Inparanoid score	I1334
OMA	1	1.010	-	-		QHG55664
OrthoDB	1	1.010	-	-		D1519639at2759
OrthoFinder	1	1.000	-	-		FOG0005713
OrthoInspector	1	1.000	-	-		oto2910
orthoMCL	1	0.900	-	-		OOG6_103302
Panther	1	1.100	-	-	LDO	PTHR46098
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4110
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980