Protein Alignment Mt2 and DNMT1

DIOPT Version :9

• Sequence 1: NP_001036355.1
• Gene: Mt2 / 34632
• FlyBaseID: FBgn0028707
• Length: 345
• Species: Drosophila melanogaster
• Sequence 2: NP_001124295.1
• Gene: DNMT1 / 1786
• HGNCID: 2976
• Length: 1632
• Species: Homo sapiens
• Identity: / - (0%)
• Similarity: / - (0%)
• Gaps: / - (0%)

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mt2	NP_001036355.1	AdoMet_MTases	3..342	CDD:302624
DNMT1	NP_001124295.1	Interaction with DNMT3A. /evidence=ECO:0000269|PubMed:12145218	1..148
		Interaction with DMAP1. /evidence=ECO:0000269|PubMed:10888872	1..120
		DMAP_binding	16..105	CDD:283995
		Interaction with DNMT3B. /evidence=ECO:0000269|PubMed:12145218	165..233
		Interaction with PCNA. /evidence=ECO:0000269|PubMed:9302295	179..190
		Nuclear localization signal. /evidence=ECO:0000255	193..221
		Interaction with the PRC2/EED-EZH2 complex. /evidence=ECO:0000250	324..622
		Homodimerization	326..518
		DNA replication foci-targeting sequence. /evidence=ECO:0000250	347..566
		DNMT1-RFD	415..550	CDD:288868
		zf-CXXC	661..707	CDD:251032
		Required for activity	667..713
		Autoinhibitory linker	709..770
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	715..745
		BAH_Dnmt1_I	770..893	CDD:240107
		BAH_Dnmt1_II	981..1117	CDD:240062
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1111..1146
		6 X 2 AA tandem repeats of K-G	1125..1136
		Interaction with the PRC2/EED-EZH2 complex. /evidence=ECO:0000250	1137..1632
		Dcm	1154..1608	CDD:223348
		Catalytic	1155..1632
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:P13864	1166..1167
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PTA	1184..1185
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:P13864	1206..1207

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910