Protein Alignment prd and ESX1

DIOPT Version :10

• Sequence 1: NP_723721.1
• Gene: prd / 34629
• FlyBaseID: FBgn0003145
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_703149.1
• Gene: ESX1 / 80712
• HGNCID: 14865
• Length: 406
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 119/572 - (20%)
• Similarity: 164/572 - (28%)
• Gaps: 248/572 - (43%)

  Fly   113 YKRSSPGMFSWEIREKLIREGVCDRSTAPSVSAISRLVRGRDAPLDNDMSSASGSPAGDGTKASS 177
            |..|..|..|..:.|.:  |.|.|.    .::..|.:.||.:     |..:....|. .||:|.:
Human     7 YTHSDIGYRSLAVGEDI--EEVNDE----KLTVTSLMARGGE-----DEENTRSKPE-YGTEAEN 59

  Fly   178 SCGSDVS-----------GGHHNNGKPSDEDISDCESE----PGIALKRKQ-------------- 213
            :.|::.|           |||....:..:..::..|.:    |.:.||::|
Human    60 NVGTEGSVPSDDQDREGGGGHEPEQQQEEPPLTKPEQQQEEPPLLELKQEQEEPPQTTVEGPQPA 124

  Fly   214 ---------------RRCRTTFSASQLDELERAFERTQYPDIYTREELAQRTNLTEARIQVWFSN 263
                           ||.||.|:..||.|||..|:.:||||:..||.||.|.||||.|:||||.|
Human   125 EGPQTAEGPQPPERKRRRRTAFTQFQLQELENFFDESQYPDVVARERLAARLNLTEDRVQVWFQN 189

  Fly   264 RRARLRK-------QHTSVS----------GG----APGGAAASVSHVAASSSLPSVVSSVPSMA 307
            |||:.::       ::|:.:          ||    ||....|...|:......|.|: .||.|.
Human   190 RRAKWKRNQRVLMLRNTATADLAHPLDMFLGGAYYAAPALDPALCVHLVPQLPRPPVL-PVPPMP 253

  Fly   308 PLAMMPGSLDPATVYQQQYDFYGSHANISVSAAAPMASSNLSPGITTTPPHHHQFYNPSANTASY 372
            |                               ..||......|.|...||            .:.
Human   254 P-------------------------------RPPMVPMPPRPPIAPMPP------------MAP 275

  Fly   373 IMPGENGNTTPTGNIIVSSYETQLGSVYGTETETHQTMPRNESPNESVSSAFGQLPPTPNSLSAV 437
            :.||......|.|                         ||           ...:||
Human   276 VPPGSRMAPVPPG-------------------------PR-----------MAPVPP-------- 296

  Fly   438 VSGAGVTSSSGANSGADPSQSLANASAGSEELSAALKVESVDLIAASQSQLYGGWSSMQALRPNA 502
                                                                  |..|..:.|..
Human   297 ------------------------------------------------------WPPMAPVPPWP 307

  Fly   503 PLSPEDSLNSTSSTSQALDVTAHQMFHPYQHTPQYASY-PAPGHAHSHHGHPHAPHPHAHPHPQY 566
            |::|               |.......|....|..|.. |.|..|....|.|.||.|   |.|..
Human   308 PMAP---------------VPTGPPMAPVPPGPPMARVPPGPPMARVPPGPPMAPLP---PGPPM 354

  Fly   567 AGAHPHYPPPSSSAHFMPQNFNAAAFPSPSKVNYTTMPP-----QPFYPSWY 613
            |...|  .||.:.   :|.....|..|..|.|.:|.:.|     .|...|:|
Human   355 APLPP--GPPMAP---LPPGPPMAPLPPRSHVPHTGLAPVHITWAPVINSYY 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prd	NP_723721.1	PAX	27..154	CDD:238076	11/40 (28%)
		Homeodomain	214..270	CDD:459649	33/55 (60%)
ESX1	NP_703149.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		4/13 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..142		19/114 (17%)
		PLN02328	45..>148	CDD:215187	19/103 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	138..143		2/4 (50%)
		Homeodomain	140..196	CDD:459649	33/55 (60%)
		15 X 9 AA tandem repeats of P-P-x-x-P-x-P-P-x	244..378		46/298 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..364		11/27 (41%)