DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prd and SHOX

DIOPT Version :9

Sequence 1:	NP_723721.1	Gene:	prd / 34629	FlyBaseID:	FBgn0003145	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_000442.1	Gene:	SHOX / 6473	HGNCID:	10853	Length:	292	Species:	Homo sapiens

Alignment Length:	333	Identity:	96/333 - (28%)
Similarity:	127/333 - (38%)	Gaps:	96/333 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 VSKILNRYQETGSIRPGVIGGSKPRIATPEIENRIEEYKRSSPGMFSWEIREKLIREGVCDRSTA 140
            |||..::..:.|:...|..||.|..|...|:   :|
Human     8 VSKSFDQKSKDGNGGGGGGGGKKDSITYREV---LE----------------------------- 40

  Fly   141 PSVSAISRLVRGRDAPLDNDMSSASGSPAGDGTKASSSCGSDVSGGHHNNGKPS---------DE 196
                  |.|.|.|:.       ..|.|...|.|:....|...:...|.:|.|..         .|
Human    41 ------SGLARSREL-------GTSDSSLQDITEGGGHCPVHLFKDHVDNDKEKLKEFGTARVAE 92

  Fly   197 DISDC---------ESEPGIALKRKQRRCRTTFSASQLDELERAFERTQYPDIYTREELAQRTNL 252
            .|.:|         |.|.| ..|.||||.||.|:..||:||||.|:.|.|||.:.||||:||..|
Human    93 GIYECKEKREDVKSEDEDG-QTKLKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGL 156

  Fly   253 TEARIQVWFSNRRARLRKQHTSVSGGAPGGAAASVSHVAASSSLPSVVSSVPSMAPLAMMPGSLD 317
            :|||:||||.||||:.|||...:..|...|.|   :|:.|....|.|     :|..|.|
Human   157 SEARVQVWFQNRRAKCRKQENQMHKGVILGTA---NHLDACRVAPYV-----NMGALRM------ 207

  Fly   318 PATVYQQQYDFYGSHANISVSAAAPMASSNL---SPGITTTPPHHHQFYNP------SANTASYI 373
            |....|.|....|      |:.|.|....:|   :|.:...||   .|..|      ||:.|:.:
Human   208 PFQQVQAQLQLEG------VAHAHPHLHPHLAAHAPYLMFPPP---PFGLPIASLAESASAAAVV 263

  Fly   374 MPGENGNT 381
            ......|:
Human   264 AAAAKSNS 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prd	NP_723721.1	PAX	27..154	CDD:238076	14/77 (18%)
prd	NP_723721.1	Homeobox	217..269	CDD:278475	32/51 (63%)
SHOX	NP_000442.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		8/25 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..119		6/19 (32%)
		Homeobox	120..174	CDD:395001	32/53 (60%)
		SH3-binding. /evidence=ECO:0000255	242..249		3/9 (33%)
		OAR	272..288	CDD:397759	96/333 (29%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	274..287
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910