DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prd and pax7b

DIOPT Version :9

Sequence 1:	NP_723721.1	Gene:	prd / 34629	FlyBaseID:	FBgn0003145	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001139621.1	Gene:	pax7b / 566533	ZFINID:	ZDB-GENE-080917-54	Length:	510	Species:	Danio rerio

Alignment Length:	535	Identity:	231/535 - (43%)
Similarity:	290/535 - (54%)	Gaps:	122/535 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GQGRVNQLGGVFINGRPLPNNIRLKIVEMAADGIRPCVISRQLRVSHGCVSKILNRYQETGSIRP 91
            ||||||||||||||||||||:||.||||||..||||||||||||||||||||||.||||||||||
Zfish    34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRP 98

  Fly    92 GVIGGSKPR-----IATPEIENRIEEYKRSSPGMFSWEIREKLIREGVCDRSTAP-----SVSAI 146
            |.|||||||     :|||::|.|||||||.:|||||||||:||:::|||||||.|     |||:|
Zfish    99 GAIGGSKPRQTQKQVATPDVEKRIEEYKRENPGMFSWEIRDKLLKDGVCDRSTVPSGEASSVSSI 163

  Fly   147 SRLVRGRDAPLDNDMSSASGSPAGD-GTKASSSCGSDVSGGHHNNGKPSDEDISDCESEPGIALK 210
            ||::|.|....|::.........|: .||.|      :.|...:.|:.  :::||.||||.:.||
Zfish   164 SRVLRARFGKKDDEDDCDKKDDTGEKKTKHS------IDGILGDKGRM--DEVSDVESEPDLPLK 220

  Fly   211 RKQRRCRTTFSASQLDELERAFERTQYPDIYTREELAQRTNLTEARIQVWFSNRRARLRKQHTSV 275
            |||||.||||:|.||:|||:|||||.||||||||||||||.|||||:||||||||||.|||
Zfish   221 RKQRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQ---- 281

  Fly   276 SGGAPGGAAASVSHVAASSSLPSVVSSVPSMAPLAMMPGSLDPATVYQQQYDFYGSHANISVSAA 340
               |.....|:.:|:......|:.:.::|:.    .:|.|..|.|...|  |..|     :|...
Zfish   282 ---AGANQLAAFNHLLPGGFPPTGMPTLPTY----QLPESSYPTTTLPQ--DVSG-----TVHRP 332

  Fly   341 APMASSNLSPGITTTPPHHHQFYNPSANTASYIMPGENGNTTPTGNIIVSSYETQLGSVYGTETE 405
            .|:..|.:..|..::  .....|..|:|..|:                 |||           |:
Zfish   333 QPLPPSTMHQGGLSS--DSSSAYGLSSNRHSF-----------------SSY-----------TD 367

  Fly   406 THQTMPRNESPNESVSSAFGQLPPTPNSLSAVVSGAGVTSSSGANSGADPSQSLANASA----GS 466
            |..          |.|::...:.|..|.||..|...                 |:|.||    ..
Zfish   368 TFM----------SQSASSNHMNPVSNGLSPQVMSI-----------------LSNPSAVAPQPQ 405

  Fly   467 EELSAA---LKVESVDLIAASQSQLYGGWSSMQALRPNAPLSPEDSLNST--------SSTSQAL 520
            .|.|.:   ..:|:.:.|:||.||            .:.|:...|||.|:        |:||.::
Zfish   406 HEFSISPLHSSLEASNPISASCSQ------------RSEPIKTADSLPSSQSYCPPTYSTTSYSV 458

  Fly   521 D-VTAHQMFHPYQHT 534
            | |||...:..|..|
Zfish   459 DPVTAGYQYSQYGQT 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prd	NP_723721.1	PAX	27..154	CDD:238076	105/136 (77%)
prd	NP_723721.1	Homeobox	217..269	CDD:278475	44/51 (86%)
pax7b	NP_001139621.1	PAX	34..170	CDD:238076	105/135 (78%)
		Homeobox	226..279	CDD:278475	44/52 (85%)
		Pax7	346..389	CDD:289156	15/82 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	208	1.000	Domainoid score	I2805
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2391
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126858at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		mtm6578
orthoMCL	1	0.900	-	-		OOG6_105365
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1205
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.870