Protein Alignment prd and PITX2

DIOPT Version :10

• Sequence 1: NP_723721.1
• Gene: prd / 34629
• FlyBaseID: FBgn0003145
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Alignment Length: 365
• Identity: 95/365 - (26%)
• Similarity: 149/365 - (40%)
• Gaps: 104/365 - (28%)

  Fly   137 RSTAPSVSAISR--------------LVRGRDAPLDND--------MSSASGSPAGDGTKASSSC 179
            |:....:||:|.              |..|:...||:.        :|..|...|.:..|:....
Human    13 RAAGTKLSAVSSSSCHHPQPLAMASVLAPGQPRSLDSSKHRLEVHTISDTSSPEAAEKDKSQQGK 77

  Fly   180 GSDVSGGHHNNGKPSDEDISDCESEPGIALKRKQRRCRTTFSASQLDELERAFERTQYPDIYTRE 244
            ..||..          ||.|.         |::|||.||.|::.||.|||..|:|.:|||:.|||
Human    78 NEDVGA----------EDPSK---------KKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTRE 123

  Fly   245 ELAQRTNLTEARIQVWFSNRRARLRKQHTS------VSGGAPGGAAASVSHVAASSSLPSVVSSV 303
            |:|..|||||||::|||.||||:.||:..:      .:|..|
Human   124 EIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGP----------------------- 165

  Fly   304 PSMAPLAMMPGSLDPATVYQQQYDFYGSHANISVSAAAPMASSNLSPGITTTPPHHHQF-YNPSA 367
                   ...|.:.|   |...|..| |:.|   .||..:.|::||   |.:.|..:.. .||.:
Human   166 -------QFNGLMQP---YDDMYPGY-SYNN---WAAKGLTSASLS---TKSFPFFNSMNVNPLS 213

  Fly   368 NTASYIMPGENGNTTPTGNIIVSSYETQLGSVYGTETETHQTMPRNESP--NESV-SSAFGQLPP 429
            :.:.:..|....:.:.:.:::.|:    :..|.|:...:...:....||  |.:| :.|....||
Human   214 SQSMFSPPNSISSMSMSSSMVPSA----VTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPP 274

  Fly   430 TP---------NSLSAVVSGAGVTSSSGANSGADPSQSLA 460
            ||         :||:::...|...||.|..|..:|:.:|:
Human   275 TPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLS 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prd	NP_723721.1	PAX	27..154	CDD:238076	6/30 (20%)
		Homeodomain	214..270	CDD:459649	34/55 (62%)
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	34/55 (62%)
		OAR	282..299	CDD:461067	3/16 (19%)