Protein Alignment prd and PAX6

DIOPT Version :9

• Sequence 1: NP_723721.1
• Gene: prd / 34629
• FlyBaseID: FBgn0003145
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_001355839.1
• Gene: PAX6 / 5080
• HGNCID: 8620
• Length: 503
• Species: Homo sapiens
• Alignment Length: 478
• Identity: 179/478 - (37%)
• Similarity: 237/478 - (49%)
• Gaps: 107/478 - (22%)

  Fly    27 GQGRVNQLGGVFINGRPLPNNIRLKIVEMAADGIRPCVISRQLRVSHGCVSKILNRYQETGSIRP 91
            |...||||||||:||||||::.|.||||:|..|.|||.|||.|:||:|||||||.||.|||||||
Human    85 GHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRP 149

  Fly    92 GVIGGSKPRIATPEIENRIEEYKRSSPGMFSWEIREKLIREGVCDRSTAPSVSAISRLVR----- 151
            ..|||||||:||||:.::|.:|||..|.:|:||||::|:.||||.....||||:|:|::|
Human   150 RAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASE 214

  Fly   152 ----GRDAPLD-----NDMSSASGSPAG-------DGTKASSSCGSDVSGGHHNNGKPSDEDISD 200
                |.|...|     |..:.:.|:..|       .|......|.....||.:.|...|:.:.||
Human   215 KQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSD 279

  Fly   201 CESEPGIALKRKQRRCRTTFSASQLDELERAFERTQYPDIYTREELAQRTNLTEARIQVWFSNRR 265
             |::..:.||||.:|.||:|:..|::.||:.||||.|||::.||.||.:.:|.||||||||||||
Human   280 -EAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRR 343

  Fly   266 A------RLRKQHTSVSGGAPGGAAASVSHVAASSS--------LPSVVSSVPSMAPLAMMPGSL 316
            |      :||.|....|.        :.||:..|||        :|...:.|.|....:|: |..
Human   344 AKWRREEKLRNQRRQASN--------TPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSML-GRT 399

  Fly   317 DPATVYQQQYDFYGSHANISVSAAAPMASSNLSPGITTTPPHHHQFYNPSANTASY--IMPGENG 379
            |.|...             :.||..||.|..::..:...||...|       |:||  ::|
Human   400 DTALTN-------------TYSALPPMPSFTMANNLPMQPPVPSQ-------TSSYSCMLP---- 440

  Fly   380 NTTPTGNIIVSSYETQLGSVYGTETETHQTMPRNESPNESVSSAFGQLPPTPNSLSAVVSGAGVT 444
             |:|:.|          |..|.|.|..|.....|..|                      .|...|
Human   441 -TSPSVN----------GRSYDTYTPPHMQTHMNSQP----------------------MGTSGT 472

  Fly   445 SSSGANSGADPSQSLANASAGSE 467
            :|:|..|   |..|:.....|||
Human   473 TSTGLIS---PGVSVPVQVPGSE 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prd	NP_723721.1	PAX	27..154	CDD:238076	81/135 (60%)
		Homeobox	217..269	CDD:278475	31/57 (54%)
PAX6	NP_001355839.1	PAX	85..209	CDD:128645	79/123 (64%)
		Homeobox	295..348	CDD:395001	31/52 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810