Protein Alignment prd and PAX2

DIOPT Version :10

• Sequence 1: NP_723721.1
• Gene: prd / 34629
• FlyBaseID: FBgn0003145
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_003981.3
• Gene: PAX2 / 5076
• HGNCID: 8616
• Length: 432
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 158/471 - (33%)
• Similarity: 214/471 - (45%)
• Gaps: 153/471 - (32%)

  Fly    24 MNSGQGRVNQLGGVFINGRPLPNNIRLKIVEMAADGIRPCVISRQLRVSHGCVSKILNRYQETGS 88
            |:.|.|.||||||||:||||||:.:|.:|||:|..|:|||.||||||||||||||||.||.||||
Human    13 MHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGS 77

  Fly    89 IRPGVIGGSKPRIATPEIENRIEEYKRSSPGMFSWEIREKLIREGVCDRSTAPSVSAISRLVR-- 151
            |:|||||||||::|||::.::|.||||.:|.||:||||::|:.||:||..|.||||:|:|::|
Human    78 IKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTK 142

  Fly   152 --------------GRDAPLDNDMSSASGSPAGDGTKASSSCGSDVSGGHHNNG----------- 191
                          |..||....:.|.:..|.       ||..:|..|.:..||
Human   143 VQQPFHPTPDGAGTGVTAPGHTIVPSTASPPV-------SSASNDPVGSYSINGILGIPRSNGEK 200

  Fly   192 KPSDE-----------------------DISD-----CESEPGIALKRKQRRCRTTFSASQLDEL 228
            :..||                       |:|:     .:|:.|:...||..|. .||:..||:.|
Human   201 RKRDEVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDSQSGVDSLRKHLRA-DTFTQQQLEAL 264

  Fly   229 ERAFERTQYPDIYTREELAQRTNLTEARIQVWFSNRRARLRKQHTSVSGGAPGGAAASVSHVAAS 293
            :|.|||..|||::...|                                           |:.:.
Human   265 DRVFERPSYPDVFQASE-------------------------------------------HIKSE 286

  Fly   294 S----SLPSVVSSVPSMAPLAMMPGSLDPATVYQQQYDFYGSHANISVSAAA-PMASSNLSPGIT 353
            .    |||            |:.|| ||              ....|:||:. |...||:| |..
Human   287 QGNEYSLP------------ALTPG-LD--------------EVKSSLSASTNPELGSNVS-GTQ 323

  Fly   354 TTPPHHHQFYNPSANTASYIMPGENGNTTPTGNIIVSSYETQ--LGSVYGTE-TETHQTMPRNES 415
            |.|      .....:.||..:||...:..|||.   .||.|.  .|.|.|:| :....:.|:..:
Human   324 TYP------VVTGRDMASTTLPGYPPHVPPTGQ---GSYPTSTLAGMVPGSEFSGNPYSHPQYTA 379

  Fly   416 PNES--VSSAFGQLPP 429
            .||:  .|:....:||
Human   380 YNEAWRFSNPALLMPP 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prd	NP_723721.1	PAX	27..154	CDD:238076	86/142 (61%)
		Homeodomain	214..270	CDD:459649	14/55 (25%)
PAX2	NP_003981.3	PAX	16..140	CDD:128645	84/123 (68%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75		41/55 (75%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		25/47 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..325		8/21 (38%)
		Pax2_C	305..>390	CDD:463563	28/94 (30%)