DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prd and ey

DIOPT Version :9

Sequence 1:	NP_723721.1	Gene:	prd / 34629	FlyBaseID:	FBgn0003145	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster

Alignment Length:	884	Identity:	242/884 - (27%)
Similarity:	328/884 - (37%)	Gaps:	358/884 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TVTAFAAAMHRPFFNGYSTMQDMNSGQGRVNQLGGVFINGRPLPNNIRLKIVEMAADGIRPCVIS 66
            |.:.||...:      :.|..:.:||   ||||||||:.|||||::.|.||||:|..|.|||.||
  Fly    81 TSSYFATTYY------HLTDDECHSG---VNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDIS 136

  Fly    67 RQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRIATPEIENRIEEYKRSSPGMFSWEIREKLIR 131
            |.|:||:|||||||.||.|||||||..|||||||:||.|:.::|.:|||..|.:|:||||::|::
  Fly   137 RILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQ 201

  Fly   132 EGVCDRSTAPSVSAISRLVRGRDAPLDNDM--SSASGSPAGD--GTKASSSCGSDV--------- 183
            |.||.....||||:|:|::|...|..:...  |.:|.:.||:  ..|.|.|.|.:|
  Fly   202 ENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRG 266

  Fly   184 -------------------SGGHHNNGKPSDEDI------------------------------- 198
                               |||..|:|:.|:::.
  Fly   267 TLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQS 331

  Fly   199 ----------------------------------------------------------------- 198

  Fly   332 PNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPS 396

  Fly   199 --------SDCES-----------------------------EPG-------------------- 206
                    :|.||                             |.|
  Fly   397 LAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDD 461

  Fly   207 ---IALKRKQRRCRTTFSASQLDELERAFERTQYPDIYTREELAQRTNLTEARIQVWFSNRRA-- 266
               :.||||.:|.||:|:..|:|.||:.||||.|||::.||.||.:..|.|||||||||||||
  Fly   462 QARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKW 526

  Fly   267 ----RLRKQHTSVSGGAPGGAAASVSHVAASSSL---PSVVSSVPSMAPLAMMPGSLDPATVYQQ 324
                :||.|..:.:.   .||:|:.|..:|::||   |:.:|:..|:  |:...|....:|:
  Fly   527 RREEKLRNQRRTPNS---TGASATSSSTSATASLTDSPNSLSACSSL--LSGSAGGPSVSTI--- 583

  Fly   325 QYDFYGSHANISVSAAAPMASSNLSPGITTTP-PH------------------------------ 358
              :...|.:.:|.:..||...:.:....:.|| ||
  Fly   584 --NGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVG 646

  Fly   359 -----HHQFYNPSAN---TASYIMPGENGNTTPTGNIIVSSYETQL--GSVYGTETETHQTMPRN 413
                 ||...|..|.   ....|.|..|.|:...|.:..:.:.|.|  ...||..|
  Fly   647 GHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVT--------- 702

  Fly   414 ESPNESVS-SAFGQLPP----------TPNSL-----------------------SAVVSGAGVT 444
              |..|.: ||.|.|.|          ||:||                       ....:|.|:.
  Fly   703 --PIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLG 765

  Fly   445 SSSGANSGADPSQSLANASAGSEELSAALKVESVDLIAASQSQLYGGWSSMQAL--RPNAPLSPE 507
            |...||.||..|.|      |.|.|||                        .||  .|.|..|..
  Fly   766 SGQSANLGASCSGS------GYEVLSA------------------------YALPPPPMASSSAA 800

  Fly   508 DSLNSTSSTSQALDVTAHQMFHPYQHTPQYASYPAPGHAHSHHGHPH-----------APHPHAH 561
            ||..|.:|::.| :||.|       ||....|.|:|..:.||.|..|           |...:||
  Fly   801 DSSFSAASSASA-NVTPH-------HTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAH 857

  Fly   562 PHPQYAGAHPHYPPPS---SSAHFMP--QNFNAAAFPSP 595
            ....||.:.....|.|   :|||..|  |.|.|:.|.||
  Fly   858 MSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSP 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prd	NP_723721.1	PAX	27..154	CDD:238076	77/126 (61%)
prd	NP_723721.1	Homeobox	217..269	CDD:278475	32/57 (56%)
ey	NP_001014693.1	PAX	98..221	CDD:128645	77/125 (62%)
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450846
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	1	0.900	-	-		E1_KOG0849
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840