DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prd and gsb

DIOPT Version :9

Sequence 1:	NP_723721.1	Gene:	prd / 34629	FlyBaseID:	FBgn0003145	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_523863.1	Gene:	gsb / 38005	FlyBaseID:	FBgn0001148	Length:	427	Species:	Drosophila melanogaster

Alignment Length:	607	Identity:	242/607 - (39%)
Similarity:	298/607 - (49%)	Gaps:	185/607 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AFAAAMHRPFFNGYSTMQDMNSGQGRVNQLGGVFINGRPLPNNIRLKIVEMAADGIRPCVISRQL 69
            |.:|....|:|.||..     .||||||||||||||||||||:||.:||||||.|:|||||||||
  Fly     2 AVSALNMTPYFGGYPF-----QGQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQL 61

  Fly    70 RVSHGCVSKILNRYQETGSIRPGVIGGSKPRIATPEIENRIEEYKRSSPGMFSWEIREKLIREGV 134
            |||||||||||||:|||||||||||||||||:|||:||:||||.|:|.||:||||||.|||..||
  Fly    62 RVSHGCVSKILNRFQETGSIRPGVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGV 126

  Fly   135 CDRSTAPSVSAISRLVRGRDAPLDNDMSSASGSPAGDGTKASSSCGSDVSGGHHNNGKPSDEDIS 199
            ||:..|||||:||||:||         ||.||:        |.|....:.||   .|....||.|
  Fly   127 CDKQNAPSVSSISRLLRG---------SSGSGT--------SHSIDGILGGG---AGSVGSEDES 171

  Fly   200 DCESEPGIALKRKQRRCRTTFSASQLDELERAFERTQYPDIYTREELAQRTNLTEARIQVWFSNR 264
            :.::||.:.|||||||.|||||..|:|.|||.|.||||||:||||||||.|.|||||:|||||||
  Fly   172 EDDAEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNR 236

  Fly   265 RARLRKQHTSVSGGAPGGAAASVSHVAASSSLPSVVSSVPSMAPLAMMPGSLDPATVYQQQYDFY 329
            |||||||..:                          ..|||.||
  Fly   237 RARLRKQLNT--------------------------QQVPSFAP--------------------- 254

  Fly   330 GSHANISVSAAAPMASSNLSPGITTTPPHHHQFYNPSANTASYIMPGENGNTTPTGNIIVSSYET 394
                            ::.|.|.|.|.                       :..|..|:.:|.|.:
  Fly   255 ----------------TSTSFGATPTT-----------------------SAAPAPNMGMSLYSS 280

  Fly   395 QLGSVYGTETETHQTMPRNESPNESVSSAFGQLPPTPNSLSAVVSGAGVTSSSGANSGA-DPSQS 458
            |.....|. .|.|              :|:|         .:|.|.:..:|:||.:|.| .|.|:
  Fly   281 QSWPSSGA-YENH--------------AAYG---------GSVASMSPASSTSGTSSAAHSPVQT 321

  Fly   459 LA-NASAGSEELSAALKVESVDLIAASQSQLYGGWSSMQALRPNAPLSPEDSLNSTSSTSQALDV 522
            .| ....|||.:::.                ||..|| .|..|:|..    |:..|.:||
  Fly   322 QAQQPGTGSEFMTST----------------YGVGSS-NATYPSAAY----SMPQTPATS----- 360

  Fly   523 TAHQMFHPYQHTPQYASYPAPGHAHSHHGHPHAPHPHAHPHPQYAGAHPHYPPPSSSAHFMPQNF 587
             |.|:      ..|:||..|.|   ||       ||.......:||:   :.||:|:|......:
  Fly   361 -AEQL------RSQFASAAASG---SH-------HPSTWDSYNFAGS---FFPPASAAGNHISGY 405

  Fly   588 NAAAFPSPSKVNYTTMPPQPFY 609
            :.......|.:  ||.|..|::
  Fly   406 HHQVDQKSSMM--TTAPTYPYF 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prd	NP_723721.1	PAX	27..154	CDD:238076	105/126 (83%)
prd	NP_723721.1	Homeobox	217..269	CDD:278475	41/51 (80%)
gsb	NP_523863.1	PAX	19..143	CDD:128645	103/123 (84%)
gsb	NP_523863.1	homeodomain	186..243	CDD:238039	45/56 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469591
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	1	0.900	-	-		E1_KOG0849
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126858at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		mtm6578
orthoMCL	1	0.900	-	-		OOG6_105365
Panther	1	1.100	-	-	P	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1205
	10	9.750