DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prd and pax7a

DIOPT Version :9

Sequence 1:	NP_723721.1	Gene:	prd / 34629	FlyBaseID:	FBgn0003145	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_571400.1	Gene:	pax7a / 30587	ZFINID:	ZDB-GENE-990415-201	Length:	507	Species:	Danio rerio

Alignment Length:	531	Identity:	235/531 - (44%)
Similarity:	285/531 - (53%)	Gaps:	117/531 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GQGRVNQLGGVFINGRPLPNNIRLKIVEMAADGIRPCVISRQLRVSHGCVSKILNRYQETGSIRP 91
            ||||||||||||||||||||:||.||||||..||||||||||||||||||||||.||||||||||
Zfish    34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRP 98

  Fly    92 GVIGGSKPR-IATPEIENRIEEYKRSSPGMFSWEIREKLIREGVCDRSTAP-----SVSAISRLV 150
            |.||||||| :|||::|.|||||||.:|||||||||:||:::|||||.|.|     |||:|||::
Zfish    99 GAIGGSKPRQVATPDVEKRIEEYKRENPGMFSWEIRDKLLKDGVCDRGTVPSGEASSVSSISRVL 163

  Fly   151 RGRDAPLDNDMSSASGSPAGDGTKASSSCGSDVSGGHHNNGKPSDEDISDCESEPGIALKRKQRR 215
            |.|....|:|  ........||.|.:......:.|   :.|..:||. ||.||||.:.|||||||
Zfish   164 RARFGKKDDD--DECDKKDEDGEKKTKHSIDGILG---DKGNRTDEG-SDVESEPDLPLKRKQRR 222

  Fly   216 CRTTFSASQLDELERAFERTQYPDIYTREELAQRTNLTEARIQVWFSNRRARLRKQHTSVSGGAP 280
            .||||:|.||:|||:|||||.||||||||||||||.|||||:||||||||||.|||       |.
Zfish   223 SRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQ-------AG 280

  Fly   281 GGAAASVSHVAASSSLPSVVSSVPSMAPLAMMPGSLDPATVYQQQYDFYGSHANISVSAAAPMAS 345
            ....|:.:|:......|:.:.::|:.    .:|.|..|:|...|.                  .|
Zfish   281 ANQLAAFNHLLPGGFPPTGMPTLPTY----QLPESTYPSTTLSQD------------------GS 323

  Fly   346 SNLSPGITTTPPHHHQFYNPSANTASYIMPGENGNTTPTGNIIVSSYETQLGSVYGTETETHQTM 410
            |.|.......|...||                       |.:...|     ||.||..:..|...
Zfish   324 STLHRPQPLPPSSMHQ-----------------------GGLSADS-----GSAYGLSSNRHTFS 360

  Fly   411 PRNE---SPNESVSSAFGQLPPTPNSLSAVVSGAGVTSSSGANSGADPSQ-----SLANASAGSE 467
            ..:|   ||..|.:    .:.|..|.||..|      .|..:|..|.|||     |::....|
Zfish   361 SYSETFMSPTASSN----HMNPVSNGLSPQV------MSILSNPSAVPSQPQHDFSISPLHGG-- 413

  Fly   468 ELSAALKVESVDLIAASQSQLYGGWSSMQALRPNAPLSPEDSLNST--------SSTSQALD-VT 523
                   :|:.:.|:||.||            .:.|:...|||.||        |:||.::| ||
Zfish   414 -------LEASNPISASCSQ------------RSDPIKSVDSLASTQSYCPPTYSATSYSVDPVT 459

  Fly   524 AHQMFHPYQHT 534
            |...:..|..|
Zfish   460 AGYQYSQYGQT 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prd	NP_723721.1	PAX	27..154	CDD:238076	104/132 (79%)
prd	NP_723721.1	Homeobox	217..269	CDD:278475	44/51 (86%)
pax7a	NP_571400.1	PAX	34..166	CDD:238076	104/131 (79%)
		Homeobox	223..276	CDD:278475	44/52 (85%)
		Pax7	343..386	CDD:289156	14/51 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	208	1.000	Domainoid score	I2805
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2391
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126858at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		mtm6578
orthoMCL	1	0.900	-	-		OOG6_105365
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1205
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970