Protein Alignment prd and Pax8

DIOPT Version :10

• Sequence 1: NP_723721.1
• Gene: prd / 34629
• FlyBaseID: FBgn0003145
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_035170.1
• Gene: Pax8 / 18510
• MGIID: 97492
• Length: 457
• Species: Mus musculus
• Alignment Length: 600
• Identity: 174/600 - (28%)
• Similarity: 246/600 - (41%)
• Gaps: 195/600 - (32%)

  Fly    24 MNSGQGRVNQLGGVFINGRPLPNNIRLKIVEMAADGIRPCVISRQLRVSHGCVSKILNRYQETGS 88
            :.||.|.:|||||.|:||||||..:|.:||::|..|:|||.||||||||||||||||.||.||||
Mouse     6 IRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGS 70

  Fly    89 IRPGVIGGSKPRIATPEIENRIEEYKRSSPGMFSWEIREKLIREGVCDRSTAPSVSAISRLVRGR 153
            |||||||||||::|||::..:|.:|||.:|.||:||||::|:.|||||..|.||||:|:|::|.:
Mouse    71 IRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTK 135

  Fly   154 -----DAPLDNDMSSASGSP----------AGDGTKASSSCGS--DVSG-------GHHNNGKPS 194
                 :.|:|:.:::.|.||          ....:..|.|.||  .::|       |:.|..|..
Mouse   136 VQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGNDNKRKMD 200

  Fly   195 DEDISDC----ESEPGIALKRKQRRCRTTFSASQLDELERAFERTQYPDIYTREELAQRTNLTEA 255
            |.|...|    :|:...:..||..| ..|||...|:.||..|||..||:.|
Mouse   201 DSDQDSCRLSIDSQSSSSGPRKHLR-TDTFSQHHLEALECPFERQHYPEAY-------------- 250

  Fly   256 RIQVWFSNRRARLRKQHTSVSGGAPGGAAASVSHVAASSSLPSVVSSVPSMAPLAMMPGSLDPAT 320
                                         ||.||......|          .||.::..:||
Mouse   251 -----------------------------ASPSHTKGEQGL----------YPLPLLNSALD--- 273

  Fly   321 VYQQQYDFYGSHANISVSAAAPMASSNLSPGITTTPPHHHQFYNPSANTASYIMPGENGNTTPTG 385
                             ...|.:.|||                                  ||.|
Mouse   274 -----------------DGKATLTSSN----------------------------------TPLG 287

  Fly   386 NIIVSSYETQLGSVYGTETETHQTMP-----------RNESPNESVSSAFGQLPPTPNSL--SAV 437
            .                ...||||.|           :.|:|..|.||:      ||:||  ||.
Mouse   288 R----------------NLSTHQTYPVVADPHSPFAIKQETPELSSSSS------TPSSLSSSAF 330

  Fly   438 VSGAGVTSSSGANSGADPSQSLANASAGSEELSAALKVESVDLIAASQSQLYGGWSSMQALRPNA 502
            :....|.|...|.:...|..:..:|::...:.:....:...:::.          .::....|:.
Mouse   331 LDLQQVGSGGPAGASVPPFNAFPHAASVYGQFTGQALLSGREMVG----------PTLPGYPPHI 385

  Fly   503 PLSPEDSLNSTSSTSQALDVTAHQMFHPYQHTPQYASYPAPGHAHSHHGHPHAPHPHAHPHPQY- 566
            |.|.:.|.  .||....:...:....:.|.||| |:||....         ..|:......|.|
Mouse   386 PTSGQGSY--ASSAIAGMVAGSEYSGNAYSHTP-YSSYSEAW---------RFPNSSLLSSPYYY 438

  Fly   567 -AGAHPHYPPPSSSA 580
             :.:.|..||.|::|
Mouse   439 SSTSRPSAPPTSATA 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prd	NP_723721.1	PAX	27..154	CDD:238076	83/131 (63%)
		Homeodomain	214..270	CDD:459649	13/55 (24%)
Pax8	NP_035170.1	PAX	9..133	CDD:128645	82/123 (67%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		38/55 (69%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		25/47 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..224		14/64 (22%)
		Pax2_C	344..456	CDD:463563	22/131 (17%)