DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment prd and Pax4

DIOPT Version :9

Sequence 1:NP_723721.1 Gene:prd / 34629 FlyBaseID:FBgn0003145 Length:613 Species:Drosophila melanogaster
Sequence 2:NP_035168.1 Gene:Pax4 / 18506 MGIID:97488 Length:349 Species:Mus musculus


Alignment Length:362 Identity:137/362 - (37%)
Similarity:187/362 - (51%) Gaps:63/362 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 GQGRVNQLGGVFINGRPLPNNIRLKIVEMAADGIRPCVISRQLRVSHGCVSKILNRYQETGSIRP 91
            |...||||||:|:||||||.:.|.:||::|..|:|||.|||.|:||:|||||||.||..||.:.|
Mouse     5 GLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEP 69

  Fly    92 GVIGGSKPRIATPEIENRIEEYKRSSPGMFSWEIREKLIREGVCDRSTAPSVSAISRLVRGRDAP 156
            ..|||||||:|||.:..||.:.|...|.:|:|||:.:|..||:|.:..|||||:|:|::|.    
Mouse    70 KCIGGSKPRLATPAVVARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPSVSSINRVLRA---- 130

  Fly   157 LDNDMS---SASGSPAGDGTKASSSCGSDVSGGHHNNGKPSDEDISDCESEPGIALKRKQRRCRT 218
            |..|.|   :...|||        .....:...|.|.|.|..       ..||.:     .|.||
Mouse   131 LQEDQSLHWTQLRSPA--------VLAPVLPSPHSNCGAPRG-------PHPGTS-----HRNRT 175

  Fly   219 TFSASQLDELERAFERTQYPDIYTREELAQRTNLTEARIQVWFSNRRARLRKQ-----HTSVSGG 278
            .||..|.:.||:.|:|.||||...|.:||..|:|.|..::||||||||:.|:|     ...:.|.
Mouse   176 IFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRRQEKLKWEAQLPGA 240

  Fly   279 A-----PGGAAASVSHVAASSSLPSVVSSVPSMAPLA---------MMPGSLDPAT---VYQQQY 326
            :     |..:...:|...:..|:||  :::|.:.||:         ..||.....|   .|.|.|
Mouse   241 SQDLTVPKNSPGIISAQQSPGSVPS--AALPVLEPLSPSFCQLCCGTAPGRCSSDTSSQAYLQPY 303

  Fly   327 DFYGSHANISVSAAAPMASSNLS----PGITTTPPHH 359
                    ....:..|:|||:..    |.:||.|.||
Mouse   304 --------WDCQSLLPVASSSYVEFAWPCLTTHPVHH 332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
prdNP_723721.1 PAX 27..154 CDD:238076 70/126 (56%)
Homeobox 217..269 CDD:278475 27/51 (53%)
Pax4NP_035168.1 PAX 5..129 CDD:128645 69/123 (56%)
PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381 8..64 36/55 (65%)
RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381 83..131 20/51 (39%)
Homeobox 174..226 CDD:278475 27/51 (53%)
Transcription repression 278..349 16/63 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0849
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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