Protein Alignment prd and Otx2

DIOPT Version :10

• Sequence 1: NP_723721.1
• Gene: prd / 34629
• FlyBaseID: FBgn0003145
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_001273410.1
• Gene: Otx2 / 18424
• MGIID: 97451
• Length: 297
• Species: Mus musculus
• Alignment Length: 296
• Identity: 91/296 - (30%)
• Similarity: 133/296 - (44%)
• Gaps: 53/296 - (17%)

  Fly   169 AGDGTKASSSCGSDVSGGHHNNGKPSDEDISDCESEPGIALKRKQRRCRTTFSASQLDELERAFE 233
            |.:|...::| |.|:.  |.:.|.|.  ..:.|.:    |..|||||.||||:.:|||.||..|.
Mouse    11 AVNGLSLTTS-GMDLL--HPSVGYPG--PWASCPA----ATPRKQRRERTTFTRAQLDVLEALFA 66

  Fly   234 RTQYPDIYTREELAQRTNLTEARIQVWFSNRRARLRKQHTSVSGGA-----PGGAAASVSHVAAS 293
            :|:||||:.|||:|.:.||.|:|:||||.||||:.|:|......|.     |....:|.:...:|
Mouse    67 KTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKSSPAREVSS 131

  Fly   294 SSLPSVVSSVPSMAPLAMMPGSLDPATVYQQQYDFYGSHANISVSAAAPMASSNLSPGITTTPPH 358
            .|..|...|.||...:..:..|..|.:::                  :|.:.|.||..::|:...
Mouse   132 ESGTSGQFSPPSSTSVPTIASSSAPVSIW------------------SPASISPLSDPLSTSSSC 178

  Fly   359 HHQFYNPSANTASYIMPGENGNTTPTGNIIVSSYETQLGSVYGTETETHQTMPRNESPNESVS-- 421
            ..:.|..:...||....|..|:|:..|.:...||.|.:          |..:|   .|..::|
Mouse   179 MQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPM----------HHQLP---GPGATLSPM 230

  Fly   422 ---SAFGQLPPTPNSLSAVVSGAGVTSSSGANSGAD 454
               :....|..:|.|||....||   ||.|.||..|
Mouse   231 GTNAVTSHLNQSPASLSTQGYGA---SSLGFNSTTD 263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prd	NP_723721.1	PAX	27..154	CDD:238076
		Homeodomain	214..270	CDD:459649	33/55 (60%)
Otx2	NP_001273410.1	Homeodomain	47..102	CDD:459649	33/54 (61%)
		TF_Otx	161..242	CDD:427350	20/93 (22%)