Protein Alignment prd and DUXB

DIOPT Version :10

• Sequence 1: NP_723721.1
• Gene: prd / 34629
• FlyBaseID: FBgn0003145
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_001338236.1
• Gene: DUXB / 100033411
• HGNCID: 33345
• Length: 345
• Species: Homo sapiens
• Alignment Length: 350
• Identity: 78/350 - (22%)
• Similarity: 123/350 - (35%)
• Gaps: 124/350 - (35%)

  Fly    92 GVIGGSKPRIATPEI-ENRIEEYKRSSPGMF-SW---------EIREKLIRE-GVCDRSTAPSVS 144
            |..||    |...|. .||| :|.:|...:. ||         ..||:|.:| ||.:    .::.
Human     5 GTSGG----ILQKEFWRNRI-QYNQSQKDILQSWFQHDPFPDKAAREQLAKEIGVPE----SNIQ 60

  Fly   145 AISRLVRGRDAPLDNDMSSASGSPAGDGTKASSSCGSDVSGGHHNNGKPSDEDISDCESEPGIAL 209
            ...:..|.:...||....|.                .|.:.||..:...:.|           .|
Human    61 VWFKNYRVKQRKLDYKCFSE----------------KDQTQGHDQSQHLTQE-----------YL 98

  Fly   210 KRKQRRCRTTFSASQLDELERAFERTQYPDIYTREELAQRTNLTEARIQVWFSNRR------ARL 268
            .::.|:.:|..:.:|.:.|.:||||..:|||.||::||::|.|.|:|||:||..:|      :|:
Human    99 PKEARQKQTFITWTQKNRLVQAFERNPFPDIATRKKLAEQTGLQESRIQMWFQKQRSLYLKKSRM 163

  Fly   269 RKQHTSVS----------GGAP--------GGAAASVSHVAAS-SSLPSVVSSV----------- 303
            ...:..|.          |..|        .....|.||.::. .:||.|:.|.
Human   164 EPMNLLVDDPNERPDATVGWHPINLFLPTDSSHYFSCSHSSSGHETLPPVLPSTQAPWDPFRFHV 228

  Fly   304 -----------------------PSMAP-----LAMMPGSLDPAT----VYQQQYDFYGSHANIS 336
                                   |.:.|     |.::...||..|    .||:::..:..|:...
Human   229 SQGPNVMIMQPTQAVQEGEKSDQPLIIPNHLLTLPILTKDLDTPTPFWLQYQEEHQNHKEHSGSG 293

  Fly   337 VSAAAPMASSNLSPGITTTPPHHHQ 361
            |    |...|:..|    .|.|..|
Human   294 V----PQVKSHSQP----EPEHREQ 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prd	NP_723721.1	PAX	27..154	CDD:238076	19/73 (26%)
		Homeodomain	214..270	CDD:459649	25/61 (41%)
DUXB	NP_001338236.1	homeodomain	16..72	CDD:238039	14/60 (23%)
		homeodomain	103..161	CDD:238039	24/57 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..314		7/36 (19%)