Protein Alignment firl and HSD17B6

DIOPT Version :10

• Sequence 1: NP_001033900.2
• Gene: firl / 34627
• FlyBaseID: FBgn0032405
• Length: 318
• Species: Drosophila melanogaster
• Sequence 2: NP_003716.2
• Gene: HSD17B6 / 8630
• HGNCID: 23316
• Length: 317
• Species: Homo sapiens
• Alignment Length: 226
• Identity: 57/226 - (25%)
• Similarity: 99/226 - (43%)
• Gaps: 27/226 - (11%)

  Fly    33 ILLELFVSLVQIVLPKKQKDVSGEI----VLITGTGHGIGRELALHYASLGSTVV--CVDIDGKN 91
            :.|..||.|..::...:::.|...:    |.|||...|.|..||....:.|..|:  |:...|..
Human     3 LYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAE 67

  Fly    92 NL--QTVEKAKRLNLGEVYSYSCDVSKRDEVTALADRIKSDVGCISV--LVNNVGIMPTHPILQ- 151
            .|  ||.::.:.:.|        ||:|.:.:.|....:|..||...:  ||||.||:....:.:
Human    68 QLRGQTSDRLETVTL--------DVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEW 124

  Fly   152 QSAEEIQRVFDVNVFSQFWTIQAFLPHMQEKCRGHIICMSSIAGLVGISNLVPYCATKFAVRGLM 216
            .:.|:...:..||:........:.|| :..:.||.|:.:|||.|.|... :..||.:|:.|....
Human   125 LNTEDSMNMLKVNLIGVIQVTLSMLP-LVRRARGRIVNVSSILGRVAFF-VGGYCVSKYGVEAFS 187

  Fly   217 EALHAELRQ-GPFRDLIRTTTIFPYMTNTGL 246
            :.|..|::. |     ::.:.:.|....||:
Human   188 DILRREIQHFG-----VKISIVEPGYFRTGM 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
firl	NP_001033900.2	17beta-HSDXI-like_SDR_c	57..299	CDD:187598	52/202 (26%)
HSD17B6	NP_003716.2	type2_17beta_HSD-like_SDR_c	30..306	CDD:187665	52/199 (26%)