Protein Alignment firl and HSD17B2

DIOPT Version :10

• Sequence 1: NP_001033900.2
• Gene: firl / 34627
• FlyBaseID: FBgn0032405
• Length: 318
• Species: Drosophila melanogaster
• Sequence 2: NP_002144.1
• Gene: HSD17B2 / 3294
• HGNCID: 5211
• Length: 387
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 68/275 - (24%)
• Similarity: 117/275 - (42%)
• Gaps: 40/275 - (14%)

  Fly    43 QIVLPKKQKDVSGEIVLITGTGHGIGRELALHYASLGSTVVCVDIDGKNNLQTVEKAKRLNLGEV 107
            |.:||..||     .||:||...|:|..|..:...||.||....::  .|....|:.:|.....:
Human    75 QELLPVDQK-----AVLVTGGDCGLGHALCKYLDELGFTVFAGVLN--ENGPGAEELRRTCSPRL 132

  Fly   108 YSYSCDVSK----RDEVTALADRIKSDVGCISVLVNNVGIM--PTHPILQQSAEEIQRVFDVNVF 166
            .....|::|    :|..:.:|..:: |.|..:| :||.|::  ||...|.... :.::...||.|
Human   133 SVLQMDITKPVQIKDAYSKVAAMLQ-DRGLWAV-INNAGVLGFPTDGELLLMT-DYKQCMAVNFF 194

  Fly   167 SQFWTIQAFLPHMQEKCRGHIICMSSIAGLVGISNLVPYCATKFAVRGLMEALHAELRQGPFRDL 231
            ......:.||| :..|.:|.::.:||:.|...:..|..|.::|.||......:..||.:..
Human   195 GTVEVTKTFLP-LLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWG---- 254

  Fly   232 IRTTTIFP--YMTNTGLCKHPKVKFPSILGLLDP-KQVAKRIVEAHRTDLMEVTIPSCLLYINNW 293
            |:..:|.|  ::||             |.|..|. :::.|.|::....::.|......:|...|:
Human   255 IKVASIQPGGFLTN-------------IAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRNF 306

  Fly   294 TRLLPDHCGLMLKDF 308
            ..|:.   .|..|||
Human   307 LLLIN---SLASKDF 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
firl	NP_001033900.2	17beta-HSDXI-like_SDR_c	57..299	CDD:187598	59/250 (24%)
HSD17B2	NP_002144.1	type2_17beta_HSD-like_SDR_c	83..362	CDD:187665	64/267 (24%)