Protein Alignment firl and HSD17B3

DIOPT Version :10

• Sequence 1: NP_001033900.2
• Gene: firl / 34627
• FlyBaseID: FBgn0032405
• Length: 318
• Species: Drosophila melanogaster
• Sequence 2: NP_000188.1
• Gene: HSD17B3 / 3293
• HGNCID: 5212
• Length: 310
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 90/341 - (26%)
• Similarity: 132/341 - (38%)
• Gaps: 95/341 - (27%)

  Fly    22 DVL-QFFELYVRILLELFVSLVQI----------------VLPKKQKDVSGEIVLITGTGHGIGR 69
            ||| |||     ||..|.|.|..:                ||||......|:..:|||.|.|||:
Human     3 DVLEQFF-----ILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGIGK 62

  Fly    70 ELALHYASLGSTVVCVDIDGKNNLQTVEK-------AKRLNLGEVYSYSCDVSKRDEVTALADRI 127
            ..:...|..|..||.:.       :|:||       .:|.....|.....|.:|.|    :.:.|
Human    63 AYSFELAKRGLNVVLIS-------RTLEKLEAIATEIERTTGRSVKIIQADFTKDD----IYEHI 116

  Fly   128 KSDVGC--ISVLVNNVG----IMPTHPILQQSAEEIQRVFDVNVFSQFWTIQAFLPHMQEKCRGH 186
            |..:..  |.:||||||    ::|:|  ...:.:|||.:...|:.|.....|..|.||:.:.:|.
Human   117 KEKLAGLEIGILVNNVGMLPNLLPSH--FLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGL 179

  Fly   187 IICMSSIAGLVGISNLVP------YCATKFAVRGLMEALHAELRQGPFRDLIRTTTIFPYMTNTG 245
            |:.:||     ||: |.|      |.|:|..|....:||..|.:.   :::| ...:.||..:|.
Human   180 ILNISS-----GIA-LFPWPLYSMYSASKAFVCAFSKALQEEYKA---KEVI-IQVLTPYAVSTA 234

  Fly   246 LCKHPKVKFPSILGLLDPKQVAKRIVEAHRTDLMEVT--------------------IPSCLLYI 290
            :.|:           |:...:.|...|..:..|..||                    ||:...|.
Human   235 MTKY-----------LNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYS 288

  Fly   291 NNWTRLLPDHCGLMLK 306
            ..:.|||..|....||
Human   289 GAFQRLLLTHYVAYLK 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
firl	NP_001033900.2	17beta-HSDXI-like_SDR_c	57..299	CDD:187598	71/280 (25%)
HSD17B3	NP_000188.1	17beta-HSD1_like_SDR_c	48..284	CDD:187614	68/269 (25%)