Protein Alignment firl and DHRS9

DIOPT Version :10

• Sequence 1: NP_001033900.2
• Gene: firl / 34627
• FlyBaseID: FBgn0032405
• Length: 318
• Species: Drosophila melanogaster
• Sequence 2: NP_001276692.1
• Gene: DHRS9 / 10170
• HGNCID: 16888
• Length: 379
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 61/260 - (23%)
• Similarity: 109/260 - (41%)
• Gaps: 58/260 - (22%)

  Fly    49 KQKDVSGEIVLITGTGHGIGRELALHYASLGSTVV--CVDIDGKNNLQTVEKAKRLNLGEVYSYS 111
            |.:|::.:.:.|||...|.|...|..:...|..|:  |:...|...|: .|.::||.     :..
Human    83 KIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALK-AETSERLR-----TVL 141

  Fly   112 CDVSKRDEVTALADRIKSDVGCISV--LVNNVGI----MPTHPILQQSAEEIQRVFDVNVFSQFW 170
            .||:..:.|...|..:|:.||...:  |:||.|:    .||..:   :.|:.:...:||:|....
Human   142 LDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL---TLEDYREPIEVNLFGLIS 203

  Fly   171 TIQAFLPHMQEKCRGHIICMSSIAGLVGISNLVPYCATKFAVRGLMEALHAELRQ-GPFRDLIRT 234
            .....|| :.:|.:|.:|.:||:.|.:.|.. ..|..:|:||.|..::|..:::. |     :..
Human   204 VTLNMLP-LVKKAQGRVINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMKAFG-----VHV 261

  Fly   235 TTIFPYMTNTGLCKHPKVKFPSILGLLDPKQVAKRIVEAHRTDLMEVTIPSCLLYINNWTRLLPD 299
            :.|.|.:..|.|.              ||.:|.::          ::.|         |.:|.||
Human   262 SCIEPGLFKTNLA--------------DPVKVIEK----------KLAI---------WEQLSPD 293

  Fly   300  299
            Human   294  293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
firl	NP_001033900.2	17beta-HSDXI-like_SDR_c	57..299	CDD:187598	57/250 (23%)
DHRS9	NP_001276692.1	type2_17beta_HSD-like_SDR_c	90..366	CDD:187665	59/253 (23%)