DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rab3-GAP and rab3gap2

DIOPT Version :9

Sequence 1:	NP_609544.2	Gene:	Rab3-GAP / 34626	FlyBaseID:	FBgn0027505	Length:	1341	Species:	Drosophila melanogaster
Sequence 2:	XP_017207090.1	Gene:	rab3gap2 / 368905	ZFINID:	ZDB-GENE-030616-610	Length:	1360	Species:	Danio rerio

Alignment Length:	1431	Identity:	401/1431 - (28%)
Similarity:	637/1431 - (44%)	Gaps:	263/1431 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MACEVKHCGEIRDFKKVQEYFGLGHD-------------------------DN------------ 28
            |:|.:...|.:::.::|:|:....|:                         ||
Zfish     1 MSCCLLEFGRVQELRQVREFLFPKHNSTGPEGDKAQAENELTWDDSDWGSWDNPEGKEDGAQAEE 65

  Fly    29 --------WLNAINHAISPTGELIAMAQGEKLAFLSTCWSSHGNGN---TYVLGWCGELE-DPNQ 81
                    ||.....::||..:|:.:|:..|.||||..|.:..:|.   |..:.|.|.|. :..:
Zfish    66 EEQHQSAPWLQDCVVSLSPCTDLLVIAREHKAAFLSAKWRTAESGQEEMTLTVTWSGTLSIEEGE 130

  Fly    82 IVTSLTCLPM-TQNKSTDGAIEWTCVAVGLCSGMVTFYTDSGVKLFSQCCQEDPVIGVKLQS--A 143
            .:.|:.|:|: :|.:|:.|..:|||:.||..||.|.|||:|||.|.:|...||||:.:|.::  .
Zfish   131 SINSVICIPLASQKRSSTGRPDWTCIVVGFSSGYVRFYTESGVLLLAQLLHEDPVLRLKCRTYEI 195

  Fly   144 PRH---SEADSLLYIIYPRCLCFIQGQDILPTLNNCRHNVQRGALERSSYPTADVVPFQKYKFKQ 205
            |||   :|....|.|:||..|..|.|..:..:|..||:.|.|.|...|.......:.::|:.. |
Zfish   196 PRHPGVTEQHEELSILYPAALVTIDGFSLFQSLRACRNQVARAAAAGSDVIQPPPLAYKKWGL-Q 259

  Fly   206 EREAVINDAAISTTQRPPTYDYIVQQTIGLGYFAKVHATPPRSSQVLAAGAEPYLGFFQAEEGYK 270
            :.:.:.:.::|..|.. ..:|.:...:|..|:.|.|..:||..||.:..|..||.|||.|.||..
Zfish   260 DMDTIADHSSIGITTL-SVFDQMKNASILGGFHASVKGSPPAMSQYITVGGGPYTGFFYAIEGSS 323

  Fly   271 TMSLGEVAKDVIGIAYKNLLGGIFRRAPEPL----PSPEES-----PLPVPTKEAPMRIRCRLYD 326
            ...|..||   :.:|.| |...:|..|...|    .:.|||     |...|....|  :|..|.|
Zfish   324 QPLLSHVA---LAVASK-LTSALFSAASGWLGWKSKNEEESVQKQKPKVEPATALP--VRFGLPD 382

  Fly   327 GKRDGLTLSVAPGGRLAVVTDNLDRVMLVDTHQAIILRVWKGYRDAQCAFVPVKE-KSVRGIKTH 390
            .:|.|.::.::|...:|.|||:..||.|:|..:.|.:|:||||||||..:|.|.| :..|.|.|.
Zfish   383 SRRHGESICLSPCNTMAGVTDDFGRVTLLDVARGIAIRMWKGYRDAQLGWVQVSEARGERDIATS 447

  Fly   391 ----KRKALFLVIYAPRMGCLDIWALQNGPKVAAFNVSKSGQLMYNNHSPLGSGGSSGSGNS-SS 450
                :|.|.||||||||.|.|::|..|:||:|.||.|.|..:|:|..|..:|.       || :|
Zfish   448 PSMPRRHAQFLVIYAPRRGILEVWGTQHGPRVGAFTVGKHCRLLYGGHRLMGV-------NSVTS 505

  Fly   451 QSRKSLAINHCLFLDPSDGSLKEIHIPFHYALSETSSQTSRDIHMLRRLRNQLRTINHGQAKDEA 515
            |..:......||| ||.:|:|:.|.||||.|||:..|:.::|:|:||||...||:    :..:.|
Zfish   506 QGWQIHTQQVCLF-DPVNGALRAITIPFHLALSDKKSERAKDMHLLRRLTTLLRS----REVEPA 565

  Fly   516 LQEIGELASELQTL-------EVRQQCLEMLLKSKKLQPQVFQSIINAFIK--KPLSESTGSEEF 571
            |     |.||.|::       .:::|.||.||.:|........|:..|.:.  |........|..
Zfish   566 L-----LESEAQSVLLDIKHPAIKKQALESLLSNKNAPVSCLTSVTRALLASLKEQDPEAVDESL 625

  Fly   572 VNQIENYKRLTDLYLALSQANQREDNEPPVEYLELS--DADLVTINKLVLLLDDGTE-KDKPAAT 633
            :....:..:|..||..:...:..:.:....|:...|  :.||..:..   :|...|| ..:|:
Zfish   626 LQFCSSQLKLLQLYTDVQLLHTPDTSPTEPEHPSFSGIEEDLARVGP---VLQRYTEMNSRPS-- 685

  Fly   634 REVSFKLQAEH--KTEEFVDYLSIFN-----IDSPD------GISLLPEKSDKFGAVSIDLFSQF 685
              |||...:..  ....|:..|...|     |..||      |..|.      :|.:|    .|.
Zfish   686 --VSFAQDSSGPLPVRTFLSLLEWVNGELRVIKQPDTDWTQLGSFLF------WGCLS----GQS 738

  Fly   686 FAQGLCFGQFKQWINQACLPSRDLLKLIIWFWLEKPFKYNNCDEVVEDMSRIAAMVQTICDLAGE 750
            ..|.:|     ..:.::.:..:.||.|::..||.|......|.:.|   |.:..::.|:..:.|.
Zfish   739 PLQRVC-----ATLQESGISPQQLLSLLLTVWLNKEKDVLKCPDAV---SHLKTLLSTLSSIKGA 795

  Fly   751 HIHDYAYNAISPWWQEVRELLLESK-QFSGLLVAIVCKTVATNLWRNRKEGSCDESSQNEDDERW 814
            ....:....:|||||:||...::|: ..:.||.|:|...||.|        :..:.::::..|.|
Zfish   796 VDESWDGQCVSPWWQQVRTACVQSESSAAALLAALVAHHVAKN--------AITKLAESKFQEGW 852

  Fly   815 ERISHDEAQWGLLTGKLEDVAVLGAILSKPLICRDPVGPEMSYEPPDCSLKSIVSSGKGIVTELT 879
            |.:|.:..||.:...:||||..|..:|..|    .|.|...| ....||:|:::.||:|.|.:..
Zfish   853 ECVSLELEQWVVCIKQLEDVLALQTLLCLP----SPQGSTGS-AVTRCSVKTLLESGRGGVADCV 912

  Fly   880 AKWLISAQLHPSKVLEISPPENELDDESKVKIKDEPTKESVDEDAESEEDLEMAKEVYAASKEAH 944
            :|.:....:.|..:.||.....|          :|||::.:.:..|.:  ||          |..
Zfish   913 SKLIFRQGVSPDVLREILQQRRE----------NEPTQQPLLQRGEGK--LE----------ELL 955

  Fly   945 EPILERLALLRAHFPFSLESGVLLSLMSWQYMVQWSKQLSSLDHLKAALLCLNQFRTPDWALKHG 1009
            |.:.:|       ||.||...||.:..||:.:|||:|......:|:.::..|.....|.  ::.|
Zfish   956 ECVCQR-------FPNSLSPDVLFAHCSWENVVQWNKDPEVGQYLEWSVEFLKMISNPH--IQLG 1011

  Fly  1010 ICCMLWNATLKFPLQAAAKLIQKVGRLPVDKMCQQDLEMSAGKVPEFLELSLEFLQHF------- 1067
            :..|:|...:.....|||.||:|||:.|.|::|::|:.|....|..||...::.||..
Zfish  1012 VSAMMWQTFIVKRFSAAAFLIEKVGKAPKDRLCRRDVGMGDAAVRSFLGSCVQLLQALMEVSSSS 1076

  Fly  1068 ------------TASMEHDKRELHFEQ--SLSEGALPLQFLALQQHHAMPQLLRLQTELCSVLHF 1118
                        :|..|....::..|:  |.::|.:.:..|||.|......|::....|.::||.
Zfish  1077 FLPSYPFFSRADSAVEEVPPPDVSVEEAWSAADGPVSIVELALDQRSVHYPLVQHHCVLATLLHA 1141

  Fly  1119 VSFFQLRIPKPLTTLFDSMSNKALLADINKELPYVLPA----PDLVLQQQRTEFLCRLVTATMDL 1179
            ...|.||: ||| :||||....|...|:..  ..:||:    |:||..:|  |||..::|..:.:
Zfish  1142 AMTFSLRL-KPL-SLFDSKGKNAFFRDLAS--IQLLPSGDMDPNLVAVRQ--EFLMNVLTGWVKV 1200

  Fly  1180 IREDLEQLYILDHVFYMGKICALADSW-----EVDKL-----PILRRQVV-ELYAFGYDAEAQVL 1233
            :.|..|     :.|...|.    .|:|     |:..|     .||||.:| |||..|.|..|:.:
Zfish  1201 LAEAEE-----NGVRSSGS----EDTWPHVCMELSSLLQVNTDILRRHLVCELYNQGLDLRAEEV 1256

  Fly  1234 LQDISDDEELGRLLLEIAGRRLNLYAQSSQSTFLKIASVGHQLLAYLDNLKEPMTENNIQIAATK 1298
            :.::.|.:.||..||.:.|:||:.....|||                      .|:.|:::.|..
Zfish  1257 MMEVQDKDVLGSQLLVLTGQRLSFSLLHSQS----------------------QTKPNMELLARL 1299

  Fly  1299 P 1299
            |
Zfish  1300 P 1300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab3-GAP	NP_609544.2	RAB3GAP2_N	29..430	CDD:291327	150/424 (35%)
Rab3-GAP	NP_609544.2	RAB3GAP2_C	710..1319	CDD:291328	167/627 (27%)
rab3gap2	XP_017207090.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583791
Domainoid	1	1.000	221	1.000	Domainoid score	I2539
eggNOG	1	0.900	-	-		E1_KOG2727
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40842
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1751
OMA	1	1.010	-	-		QHG52979
OrthoDB	1	1.010	-	-		D29182at33208
OrthoFinder	1	1.000	-	-		FOG0005758
OrthoInspector	1	1.000	-	-		oto39530
orthoMCL	1	0.900	-	-		OOG6_105335
Panther	1	1.100	-	-	LDO	PTHR12472
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2746
SonicParanoid	1	1.000	-	-		X4151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840