Protein Alignment Rab3-GAP and rab3gap2

DIOPT Version :10

• Sequence 1: NP_609544.2
• Gene: Rab3-GAP / 34626
• FlyBaseID: FBgn0027505
• Length: 1341
• Species: Drosophila melanogaster
• Sequence 2: XP_017207090.2
• Gene: rab3gap2 / 368905
• ZFINID: ZDB-GENE-030616-610
• Length: 1360
• Species: Danio rerio
• Alignment Length: 1434
• Identity: 400/1434 - (27%)
• Similarity: 634/1434 - (44%)
• Gaps: 269/1434 - (18%)

  Fly     1 MACEVKHCGEIRDFKKVQEYFGLGHD-------------------------DN------------ 28
            |:|.:...|.:::.::|:|:....|:                         ||
Zfish     1 MSCCLLEFGRVQELRQVREFLFPKHNSTGPEGDKAQAENELTWDDSDWGSWDNPEGKEDGAQAEE 65

  Fly    29 --------WLNAINHAISPTGELIAMAQGEKLAFLSTCWSSHGNGN---TYVLGWCGELE-DPNQ 81
                    ||.....::||..:|:.:|:..|.||||..|.:..:|.   |..:.|.|.|. :..:
Zfish    66 EEQHQSAPWLQDCVVSLSPCTDLLVIAREHKAAFLSAKWRTAESGQEEMTLTVTWSGTLSIEEGE 130

  Fly    82 IVTSLTCLPM-TQNKSTDGAIEWTCVAVGLCSGMVTFYTDSGVKLFSQCCQEDPVIGVKLQS--A 143
            .:.|:.|:|: :|.:|:.|..:|||:.||..||.|.|||:|||.|.:|...||||:.:|.::  .
Zfish   131 SINSVICIPLASQKRSSTGRPDWTCIVVGFSSGYVRFYTESGVLLLAQLLHEDPVLRLKCRTYEI 195

  Fly   144 PRH---SEADSLLYIIYPRCLCFIQGQDILPTLNNCRHNVQRGALERSSYPTADVVPFQKYKFKQ 205
            |||   :|....|.|:||..|..|.|..:..:|..||:.|.|.|...|.......:.::|:.. |
Zfish   196 PRHPGVTEQHEELSILYPAALVTIDGFSLFQSLRACRNQVARAAAAGSDVIQPPPLAYKKWGL-Q 259

  Fly   206 EREAVINDAAISTTQRPPTYDYIVQQTIGLGYFAKVHATPPRSSQVLAAGAEPYLGFFQAEEGYK 270
            :.:.:.:.::|..|.. ..:|.:...:|..|:.|.|..:||..||.:..|..||.|||.|.||..
Zfish   260 DMDTIADHSSIGITTL-SVFDQMKNASILGGFHASVKGSPPAMSQYITVGGGPYTGFFYAIEGSS 323

  Fly   271 TMSLGEVAKDVIGIAYKNLLGGIFRRAPEPL----PSPEES-----PLPVPTKEAPMRIRCRLYD 326
            ...|..||   :.:|.| |...:|..|...|    .:.|||     |...|....|  :|..|.|
Zfish   324 QPLLSHVA---LAVASK-LTSALFSAASGWLGWKSKNEEESVQKQKPKVEPATALP--VRFGLPD 382

  Fly   327 GKRDGLTLSVAPGGRLAVVTDNLDRVMLVDTHQAIILRVWKGYRDAQCAFVPVKE-KSVRGIKTH 390
            .:|.|.::.::|...:|.|||:..||.|:|..:.|.:|:||||||||..:|.|.| :..|.|.|.
Zfish   383 SRRHGESICLSPCNTMAGVTDDFGRVTLLDVARGIAIRMWKGYRDAQLGWVQVSEARGERDIATS 447

  Fly   391 ----KRKALFLVIYAPRMGCLDIWALQNGPKVAAFNVSKSGQLMYNNHSPLGSGGSSGSGNS-SS 450
                :|.|.||||||||.|.|::|..|:||:|.||.|.|..:|:|..|..:|.       || :|
Zfish   448 PSMPRRHAQFLVIYAPRRGILEVWGTQHGPRVGAFTVGKHCRLLYGGHRLMGV-------NSVTS 505

  Fly   451 QSRKSLAINHCLFLDPSDGSLKEIHIPFHYALSETSSQTSRDIHMLRRLRNQLRTINHGQAKDEA 515
            |..:......||| ||.:|:|:.|.||||.|||:..|:.::|:|:||||...||:    :..:.|
Zfish   506 QGWQIHTQQVCLF-DPVNGALRAITIPFHLALSDKKSERAKDMHLLRRLTTLLRS----REVEPA 565

  Fly   516 LQEIGELASELQTL-------EVRQQCLEMLLKSKKLQPQVFQSIINAFIK--KPLSESTGSEEF 571
            |     |.||.|::       .:::|.||.||.:|........|:..|.:.  |........|..
Zfish   566 L-----LESEAQSVLLDIKHPAIKKQALESLLSNKNAPVSCLTSVTRALLASLKEQDPEAVDESL 625

  Fly   572 VNQIENYKRLTDLYLALSQANQREDNEPPVEYLELS--DADLVTINKLVLLLDDGTE-KDKPAAT 633
            :....:..:|..||..:...:..:.:....|:...|  :.||..:..   :|...|| ..:|:
Zfish   626 LQFCSSQLKLLQLYTDVQLLHTPDTSPTEPEHPSFSGIEEDLARVGP---VLQRYTEMNSRPS-- 685

  Fly   634 REVSFKLQAEH--KTEEFVDYLSIFN-----IDSPD------GISLLPEKSDKFGAVSIDLFSQF 685
              |||...:..  ....|:..|...|     |..||      |..|.      :|.:|    .|.
Zfish   686 --VSFAQDSSGPLPVRTFLSLLEWVNGELRVIKQPDTDWTQLGSFLF------WGCLS----GQS 738

  Fly   686 FAQGLCFGQFKQWINQACLPSRDLLKLIIWFWLEKPFKYNNCDEVVEDMSRIAAMVQTICDLAGE 750
            ..|.:|     ..:.::.:..:.||.|::..||.|......|.:.|   |.:..::.|:..:.|.
Zfish   739 PLQRVC-----ATLQESGISPQQLLSLLLTVWLNKEKDVLKCPDAV---SHLKTLLSTLSSIKGA 795

  Fly   751 HIHDYAYNAISPWWQEVRELLLESK-QFSGLLVAIVCKTVATNLWRNRKEGSCDESSQNEDDERW 814
            ....:....:|||||:||...::|: ..:.||.|:|...||.|        :..:.::::..|.|
Zfish   796 VDESWDGQCVSPWWQQVRTACVQSESSAAALLAALVAHHVAKN--------AITKLAESKFQEGW 852

  Fly   815 ERISHDEAQWGLLTGKLEDVAVLGAILSKPLICRDPVGPEMSYEPPDCSLKSIVSSGKGIVTELT 879
            |.:|.:..||.:...:||||..|..:|..|    .|.|...| ....||:|:::.||:|.|.:..
Zfish   853 ECVSLELEQWVVCIKQLEDVLALQTLLCLP----SPQGSTGS-AVTRCSVKTLLESGRGGVADCV 912

  Fly   880 AKWLISAQLHPSKVLEISPPENELDDESKVKIKDEPTKESVDEDAESEEDLEMAKEVYAASKEAH 944
            :|.:....:.|..:.||.....|          :|||::.:....|.:
Zfish   913 SKLIFRQGVSPDVLREILQQRRE----------NEPTQQPLLLRGEGK----------------- 950

  Fly   945 EPILERLALLRAHFPFSLESGVLLSLMSWQYMVQWSKQLSSLDHLKAALLCLNQFRTPDWALKHG 1009
              |.|.|..:...||.||.:.||.:..||:.:|||:|......:|:.::..|.....|.  ::.|
Zfish   951 --IEELLECVCQRFPNSLSTDVLFAHCSWENVVQWNKDPEVGQYLEWSVEFLKMISNPH--IQLG 1011

  Fly  1010 ICCMLWNATLKFPLQAAAKLIQKVGRLPVDKMCQQDLEMSAGKVPEFLELSLEFLQHFTASME-- 1072
            :..|:|...:.....|||.||:|||:.|.|::|::|:.|....|..||...::.||   |.||
Zfish  1012 VSAMMWQTFIVKRFSAAAFLIEKVGKAPKDRLCRRDVGMGDAAVRSFLGSCVQLLQ---ALMEVS 1073

  Fly  1073 ----------HDKRELHFEQ------------SLSEGALPLQFLALQQHHAMPQLLRLQTELCSV 1115
                      ..:.:...|:            |.::|.:.:..|||.|......|::....|.::
Zfish  1074 SSSFLPSYPFFSRADSAVEEVPPPDVCVEEAWSAADGPVSIVELALDQRSVHYPLVQHHCVLATL 1138

  Fly  1116 LHFVSFFQLRIPKPLTTLFDSMSNKALLADINKELPYVLPA----PDLVLQQQRTEFLCRLVTAT 1176
            ||....|.||: ||| :||||....|...|:..  ..:||:    |:||..:|  |||..::|..
Zfish  1139 LHAAMTFSLRL-KPL-SLFDSKGKNAFFRDLAS--IQLLPSGDMDPNLVAVRQ--EFLMNVLTGW 1197

  Fly  1177 MDLIREDLEQLYILDHVFYMGKICALADSW-----EVDKL-----PILRRQVV-ELYAFGYDAEA 1230
            :.::.|..|     :.|...|.    .|:|     |:..|     .||||.:| |||..|.|..|
Zfish  1198 VKVLGEAEE-----NGVRSSGS----EDTWPHVCMELSSLLQVNTDILRRHLVCELYNQGLDLRA 1253

  Fly  1231 QVLLQDISDDEELGRLLLEIAGRRLNLYAQSSQSTFLKIASVGHQLLAYLDNLKEPMTENNIQIA 1295
            :.::.::.|.:.||..||.:.|:||:.....|||                      .|:.|:::.
Zfish  1254 EEVMMEVQDKDVLGSQLLVLTGQRLSFSLLHSQS----------------------QTKPNMELL 1296

  Fly  1296 ATKP 1299
            |..|
Zfish  1297 ARLP 1300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab3-GAP	NP_609544.2	RAB3GAP2_N	29..430	CDD:464240	150/424 (35%)
		RAB3GAP2_C	708..1319	CDD:464241	167/632 (26%)
rab3gap2	XP_017207090.2	None