Protein Alignment Rab3-GAP and Rab3gap2

DIOPT Version :10

• Sequence 1: NP_609544.2
• Gene: Rab3-GAP / 34626
• FlyBaseID: FBgn0027505
• Length: 1341
• Species: Drosophila melanogaster
• Sequence 2: NP_001035244.2
• Gene: Rab3gap2 / 289350
• RGDID: 1311518
• Length: 1387
• Species: Rattus norvegicus
• Alignment Length: 1389
• Identity: 396/1389 - (28%)
• Similarity: 636/1389 - (45%)
• Gaps: 226/1389 - (16%)

  Fly    28 NWLNAINHAISPTGELIAMAQGEKLAFLSTCWSSHGNGN---TYVLGWCGELE-DPNQIVTSLTC 88
            :||.....::|||.:|:.:|:.:|.|||...|.....|.   .:.:||.|.:. :..:.|||..|
  Rat    72 SWLQECVLSLSPTSDLMVIAREQKAAFLVPKWKHSDKGKEEMQFAVGWSGSVSAEEGEYVTSALC 136

  Fly    89 LPM-TQNKSTDGAIEWTCVAVGLCSGMVTFYTDSGVKLFSQCCQEDPVIGVKLQS--APRH---S 147
            :|: :|.:|:.|..:|||:.||..||.|.|||:|||.|.:|...||.|:.:|.::  .|||   :
  Rat   137 IPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTESGVLLLAQLLNEDRVLQLKCRTYEIPRHPGVT 201

  Fly   148 EADSLLYIIYPRCLCFIQGQDILPTLNNCRHNVQRGALERSSYPTADVVPFQKYKFKQEREAVIN 212
            |.:..|.|:||..:..|.|..:..:|..||:.|.:.|...:.......:.::|:.. |:.:.:|:
  Rat   202 EQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGL-QDIDTIID 265

  Fly   213 DAAISTTQRPPTYDYIVQQTIGLGYFAKVHATPPRSSQVLAAGAEPYLGFFQAEEGYKTMSLGEV 277
            .|:|......|.........|| |:.|.:..:||..||.:..|:.|:.|||.|.||.....|..|
  Rat   266 HASIGIMTLSPFDQMKTASNIG-GFNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHV 329

  Fly   278 AKDVIGIAYKNLLGGIFRRAP---------EPLPSPEESPLPVPTKEAPMRIRCRLYDGKRDGLT 333
            |   :.:|.| |...:|..|.         |.....::.|...|.  .|:.:|..|.|.:|.|.:
  Rat   330 A---LAVASK-LTSALFSAASGWLGWKSKHEEETVQKQKPKMEPA--TPLAVRFGLPDSRRHGES 388

  Fly   334 LSVAPGGRLAVVTDNLDRVMLVDTHQAIILRVWKGYRDAQCAFVPVKEK---------------S 383
            :.::|...||.|||:..||:|:|..:.|.:|:||||||||..::.:.|.               :
  Rat   389 ICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQIGWIQIVEDLHERVPEKGDFSPFGN 453

  Fly   384 VRGIKTHKRKALFLVIYAPRMGCLDIWALQNGPKVAAFNVSKSGQLMYNNHSPLGSGGSSGSGNS 448
            .:|   ..|.|.||||||||.|.|::|:.|.||:|.||||.|..:|:|..:..:      |..|.
  Rat   454 TQG---PSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKHCRLLYPGYKIM------GLNNV 509

  Fly   449 SSQSRKSLAINHCLFLDPSDGSLKEIHIPFHYALSETSSQTSRDIHMLRRLRNQLRTINHGQAKD 513
            :|||.:......|| :||...|:|.:::|||.|||:..|:.::|:|::::|...||..:......
  Rat   510 TSQSWQPQTYQICL-VDPVSASVKVVNVPFHLALSDKKSERAKDLHLVKKLAALLRAKSPRPDSF 573

  Fly   514 EALQEIGELASELQTLEVRQQCLEMLLKSKKLQPQVFQSIINA---FIKKPLSESTGSEEFVNQI 575
            ||  ||.||..:::....::|.||.:|.|.::.....:::...   .:|....||. .|..:...
  Rat   574 EA--EIKELILDIKYPATKKQALESILASDRVSFSCLRNVTQTSMDTLKNQELESV-DEGLLQFC 635

  Fly   576 ENYKRLTDLYLALSQANQRE--------DNEPPVEYLELSDADLVTINKLVLLLDDGTEKDKPAA 632
            .:..:|..||.::||.|..:        ||:..| .|.|.|.:|:.:..|:       ||.|...
  Rat   636 ASKLKLLHLYESVSQLNTLDFHSDTPFSDNDLAV-LLRLDDKELLKLRALL-------EKYKQEN 692

  Fly   633 TR-EVSFKLQAEH--KTEEFVDYLSIFNIDSPDGISLLPEKSDKFGAVSIDLFSQFF-------- 686
            |: .|.|...|:.  ..:.|::||..    ..|.:|:  .|:.:...|::..|  ||
  Rat   693 TKATVRFSEDADGVLPVKTFLEYLDY----EKDALSI--RKTSEEECVALGSF--FFWKCLHGES 749

  Fly   687 -AQGLCFGQFKQWINQACLPSRDLLKLIIWFWLEKPFKYNNCDEVVEDMSRIAAMVQTICDLAGE 750
             .:.:|     ..:..|.|..:.||.|::..||.|       ::.:.|..:....:.|:..|..:
  Rat   750 STEDMC-----HTLESAGLSPQQLLSLLLSVWLSK-------EKDILDKPQSVCCLHTMLSLLSK 802

  Fly   751 H----IHDYAYNAISPWWQEVRELLLESK-QFSGLLVAIVCKTVATNLWRNRKEGSCDESSQNED 810
            .    ...:...::|||||::|...::|: ..:.||.|.|..:||..:..:..:....:...:.|
  Rat   803 MKVAIDETWDSQSVSPWWQQMRMACIQSENNGAALLSAHVGHSVAAQMSSSATDKKFSQMVLDAD 867

  Fly   811 DE----RWERISHDEAQWGLLTGKLEDVAVLGAIL---SKPLICRDPVGPEMS--YEP-PDCSLK 865
            .|    .||.:|.|...|.||..:|||..:|..:|   :.|     |.....|  .|| |..|:|
  Rat   868 AEALTDSWEALSLDTEYWKLLLRQLEDCLILQTLLHSRASP-----PAAKASSPQTEPLPRLSVK 927

  Fly   866 SIVSSGKGIVTELTAKWLISAQLHPSKVLEISPPENELDDESKVKIKDEPTK---ESVDEDAESE 927
            .::..|||.:.:..|||:....|.| ::|:.:..|.::::      .|||.:   .|..|.:|.|
  Rat   928 KLLEGGKGGIADSVAKWIFKQDLSP-ELLKCANREKDVEN------PDEPREGIARSPPEVSEVE 985

  Fly   928 EDLEMAKEVYAASKEAHEPILERLALLRAHFPFSLESGVLLSLMSWQYMVQWSKQ-------LSS 985
            .||...            |.|.|||.  ..||.|||..||.:...|:|:|||:|.       :.|
  Rat   986 TDLGAV------------PDLLRLAY--EQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFLVRS 1036

  Fly   986 LDHLKAALLCLNQFRTPDWALKHGICCMLWNATLKFPLQAAAKLIQKVGRLPVDKMCQQDLEMSA 1050
            ::||:..|       .|.  :::||..|:||..|.....||..|:.|||:.|.|::|::|:.||.
  Rat  1037 IEHLRHIL-------NPH--VQNGISLMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRRDVGMSD 1092

  Fly  1051 GKVPEFLELSLEFLQHFTASMEHD-KRE------LHFEQS-LS-EGALPLQFLALQQHHAMPQLL 1106
            ..:..||...|:.||   .|:|.| .|:      |..|.: || ||...:..|||:|......|:
  Rat  1093 TALTSFLGSCLDLLQ---TSLEADISRDEVQVPVLDTEDAWLSVEGPTSIVELALEQKPIHYPLV 1154

  Fly  1107 RLQTELCSVLHFVSFFQLRIPKPLTTLFDSMSNKALLADINKELPYVLPA----PDLVLQQQRTE 1167
            ...:.|||:|:....|.|:..||| .||||....|...|:..  ..:||:    |:.:  ..|.:
  Rat  1155 EHHSILCSILYAAMSFSLKSVKPL-ALFDSKGKNAFFKDLTS--IQLLPSGEMDPNFI--SVRQQ 1214

  Fly  1168 FLCRLVTATM---------------DLIREDLEQLYILDHVFYMGKICALADSWEVDKLPILRRQ 1217
            ||.::|:|.:               |...:||.         :......||...:|.:..|.|..
  Rat  1215 FLLKVVSAAVQAQHSKDRDPSARAADTHGQDLN---------WTALAVDLAHHLQVSEDVIRRHY 1270

  Fly  1218 VVELYAFGYDAEAQVLLQDISDDEELGRLLLEIAGRRLNLYAQSSQSTFLKIASVGHQLLAYLDN 1282
            |.|||::|.|...:..:..:.|.|.|...||.:.|:||      :.:.|......|.:|||.|..
  Rat  1271 VGELYSYGADLLGEEAILQVQDKEVLASQLLVLTGQRL------AHALFHTQTKEGMELLARLPP 1329

  Fly  1283 -----LK----EPMTENNIQIAAT 1297
                 ||    :.:....:.:|||
  Rat  1330 TLCTWLKAMNPQDLQNTGVPVAAT 1353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab3-GAP	NP_609544.2	RAB3GAP2_N	29..430	CDD:464240	142/434 (33%)
		RAB3GAP2_C	708..1319	CDD:464241	180/652 (28%)
Rab3gap2	NP_001035244.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..69
		RAB3GAP2_N	73..497	CDD:464240	142/434 (33%)
		RAB3GAP2_C	779..1365	CDD:464241	175/640 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	960..983		6/28 (21%)