Protein Alignment Rab3-GAP and RAB3GAP2

DIOPT Version :10

• Sequence 1: NP_609544.2
• Gene: Rab3-GAP / 34626
• FlyBaseID: FBgn0027505
• Length: 1341
• Species: Drosophila melanogaster
• Sequence 2: NP_036546.2
• Gene: RAB3GAP2 / 25782
• HGNCID: 17168
• Length: 1393
• Species: Homo sapiens
• Alignment Length: 1434
• Identity: 407/1434 - (28%)
• Similarity: 658/1434 - (45%)
• Gaps: 244/1434 - (17%)

  Fly    28 NWLNAINHAISPTGELIAMAQGEKLAFLSTCWSSHGNGN---TYVLGWCGELE-DPNQIVTSLTC 88
            :||.....::|||.:|:.:|:.:|..||...|.....|.   .:.:||.|.|. :..:.|||..|
Human    73 SWLQDCVLSLSPTNDLMVIAREQKAVFLVPKWKYSDKGKEEMQFAVGWSGSLNVEEGECVTSALC 137

  Fly    89 LPM-TQNKSTDGAIEWTCVAVGLCSGMVTFYTDSGVKLFSQCCQEDPVIGVKLQS--APRH---S 147
            :|: :|.:|:.|..:|||:.||..||.|.|||::||.|.:|...||||:.:|.::  .|||   :
Human   138 IPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDPVLQLKCRTYEIPRHPGVT 202

  Fly   148 EADSLLYIIYPRCLCFIQGQDILPTLNNCRHNVQRGALERSSYPTADVVPFQKYKFKQEREAVIN 212
            |.:..|.|:||..:..|.|..:..:|..||:.|.:.|...:.......:.::|:.. |:.:.:|:
Human   203 EQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGL-QDIDTIID 266

  Fly   213 DAAISTTQRPPTYDYIVQQTIGLGYFAKVHATPPRSSQVLAAGAEPYLGFFQAEEGYKTMSLGEV 277
            .|::......|.........|| |:.|.:..:||..||.:..|:.|:.|||.|.||.....|..|
Human   267 HASVGIMTLSPFDQMKTASNIG-GFNAAIKNSPPAMSQYITVGSNPFTGFFYALEGSTQPLLSHV 330

  Fly   278 AKDVIGIAYKNLLGGIFRRAP---------EPLPSPEESPLPVPTKEAPMRIRCRLYDGKRDGLT 333
            |   :.:|.| |...:|..|.         |.....::.|...|.  .|:.:|..|.|.:|.|.:
Human   331 A---LAVASK-LTSALFNAASGWLGWKSKHEEEAVQKQKPKVEPA--TPLAVRFGLPDSRRHGES 389

  Fly   334 LSVAPGGRLAVVTDNLDRVMLVDTHQAIILRVWKGYRDAQCAFVP--------VKEKS----VRG 386
            :.::|...||.|||:..||:|:|..:.|.:|:||||||||..::.        |.||:    ...
Human   390 ICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQIGWIQTVEDLHERVPEKADFSPFGN 454

  Fly   387 IKTHKRKALFLVIYAPRMGCLDIWALQNGPKVAAFNVSKSGQLMYNNHSPLGSGGSSGSGNSSSQ 451
            .:...|.|.||||||||.|.|::|:.|.||:|.||||.|..:|:|..:..:      |..|.:||
Human   455 SQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKHCRLLYPGYKIM------GLNNVTSQ 513

  Fly   452 SRKSLAINHCLFLDPSDGSLKEIHIPFHYALSETSSQTSRDIHMLRRLRNQLRTINHGQAKDEAL 516
            |.:......|| :||..||:|.:::|||.|||:..|:.::|:|::::|...|:|  .....|...
Human   514 SWQPQTYQICL-VDPVSGSVKTVNVPFHLALSDKKSERAKDMHLVKKLAALLKT--KSPNLDLVE 575

  Fly   517 QEIGELASELQTLEVRQQCLEMLLKSKKLQPQVFQSIINAFIKKPLSESTGSEEFVNQIE----- 576
            .||.||..:::....::|.||.:|.|::|.   |..:.|  |.:.|.::..|:|..:..|
Human   576 TEIKELILDIKYPATKKQALESILASERLP---FSCLRN--ITQTLMDTLKSQELESVDEGLLQF 635

  Fly   577 --NYKRLTDLYLALSQANQREDN-EPPVEYLELSDADLVTINKLVLLLDDGTEKDKPAATREVSF 638
              |..:|..||.::||.|..:.: :.|     .||.||.    |:|.||   ||:        ..
Human   636 CANKLKLLQLYESVSQLNSLDFHLDTP-----FSDNDLA----LLLRLD---EKE--------LL 680

  Fly   639 KLQA---EHKTEEFVDYLSIFNI---DSPDGISLLPEKS-------DKFGAVSIDLFSQFFAQGL 690
            ||||   ::|.|.     :..|:   |..||:  ||.|:       :| ..::|...|:  .:.:
Human   681 KLQALLEKYKQEN-----TRTNVRFSDDKDGV--LPVKTFLEYLEYEK-DVLNIKKISE--EEYV 735

  Fly   691 CFGQFKQW---------------INQACLPSRDLLKLIIWFWLEKPFKYNNCDEVVEDMSRIAAM 740
            ..|.|..|               :..|.|..:.||.|::..||.|       ::.:.|..:....
Human   736 ALGSFFFWKCLHGESSTEDMCHTLESAGLSPQLLLSLLLSVWLSK-------EKDILDKPQSICC 793

  Fly   741 VQTICDLAGEH----IHDYAYNAISPWWQEVRELLLESK-QFSGLLVAIVCKTVATNLWRNRKEG 800
            :.|:..|..:.    ...:...::|||||::|...::|: ..:.||.|.|..:||..:..|..|.
Human   794 LHTMLSLLSKMKVAIDETWDSQSVSPWWQQMRTACIQSENNGAALLSAHVGHSVAAQISNNMTEK 858

  Fly   801 SCDESSQNEDDE----RWERISHDEAQWGLLTGKLEDVAVLGAILSKPLICRDPVGPEMSYEP-P 860
            ...::....|.|    .||.:|.|...|.||..:|||..:|..:|......:......:..|| |
Human   859 KFSQTVLGADSEALTDSWEALSLDTEYWKLLLKQLEDCLILQTLLHSKGNTQTSKVSSLQAEPLP 923

  Fly   861 DCSLKSIVSSGKGIVTELTAKWLISAQLHPSKVLEISPPENELDDESKVKIKDEPTKESVD---- 921
            ..|:|.::..|||.:.:..|||:......| :||:::..|.:.::      .||| ||.|:
Human   924 RLSVKKLLEGGKGGIADSVAKWIFKQDFSP-EVLKLANEERDAEN------PDEP-KEGVNRSFL 980

  Fly   922 EDAESEEDLEMAKEVYAASKEAHEPILERLALLRAHFPFSLESGVLLSLMSWQYMVQWSKQ---- 982
            |.:|.|.||              ..|.:.|.|....||.|||..||.:...|:|:|||:|.
Human   981 EVSEMEMDL--------------GAIPDLLHLAYEQFPCSLELDVLHAHCCWEYVVQWNKDPEEA 1031

  Fly   983 ---LSSLDHLKAALLCLNQFRTPDWALKHGICCMLWNATLKFPLQAAAKLIQKVGRLPVDKMCQQ 1044
               :.|::|||...         :..:::||..|:||..|.....||..|:.|||:.|.|::|::
Human  1032 RFFVRSIEHLKQIF---------NAHVQNGIALMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRR 1087

  Fly  1045 DLEMSAGKVPEFLELSLEFLQ-HFTASMEHDKRE---LHFEQS-LS-EGALPLQFLALQQHHAMP 1103
            |:.||...:..||...|:.|| ...|.:..|:.:   |..|.: || ||.:.:..|||:|.|...
Human  1088 DVGMSDTAMTSFLGSCLDLLQILMEADVSRDEIQVPVLDTEDAWLSVEGPISIVELALEQKHIHY 1152

  Fly  1104 QLLRLQTELCSVLHFVSFFQLRIPKPLTTLFDSMSNKALLADINKELPYVLPA----PDLVLQQQ 1164
            .|:...:.|||:|:.|..|.|:..||| :||||....|...|:..  ..:||:    |:.:  ..
Human  1153 PLVEHHSILCSILYAVMRFSLKTVKPL-SLFDSKGKNAFFKDLTS--IQLLPSGEMDPNFI--SV 1212

  Fly  1165 RTEFLCRLVTATMDL------IREDLEQLYILDHVFYMGK-------ICALADSWEVDKLPILRR 1216
            |.:||.::|:|.:..      :::..|:.....    .||       ...||...:|.:..:.|.
Human  1213 RQQFLLKVVSAAVQAQHSATKVKDPTEEATPTP----FGKDQDWPALAVDLAHHLQVSEDVVRRH 1273

  Fly  1217 QVVELYAFGYDAEAQVLLQDISDDEELGRLLLEIAGRRLN---LYAQSSQSTFLKIASVGHQLLA 1278
            .|.|||.:|.|...:..:..:.|.|.|...||.:.|:||.   |:.|:.:         |.:|||
Human  1274 YVGELYNYGVDHLGEEAILQVHDKEVLASQLLVLTGQRLAHALLHTQTKE---------GMELLA 1329

  Fly  1279 YLD-------NLKEPMTENNIQIAATKPDEIDVAALDRLLSHAYKYLCRRESKQLPIIGQMYNAV 1336
            .|.       ...:|....|        .|:.:|...:|::...:.|..:.       ||...|:
Human  1330 RLPPTLCTWLKAMDPQDLQN--------TEVPIATTAKLVNKVIELLPEKH-------GQYGLAL 1379

  Fly  1337 RILQ 1340
            .:::
Human  1380 HLIE 1383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab3-GAP	NP_609544.2	RAB3GAP2_N	29..430	CDD:464240	142/431 (33%)
		RAB3GAP2_C	708..1319	CDD:464241	178/664 (27%)
RAB3GAP2	NP_036546.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..67
		RAB3GAP2_N	74..498	CDD:464240	142/431 (33%)
		RAB3GAP2_C	780..1369	CDD:464241	173/652 (27%)